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Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index.
Prog Retin Eye Res. 2020 Jan 10 [Online ahead of print]PR

Abstract

The choroid is one of the most vascularized structures of the human body and plays an irreplaceable role in nourishing photoreceptors. As such, choroidal dysfunction is implicated in a multitude of ocular diseases. Studying the choroid can lead to a better understanding of disease pathogenesis, progression and discovery of novel management strategies. However, current research has produced inconsistent findings, partly due to the physical inaccessibility of the choroid and the lack of reliable biomarkers. With the advancements in optical coherence tomography technology, our group has developed a novel quantitative imaging biomarker known as the choroidal vascularity index (CVI), defined as the ratio of vascular area to the total choroidal area. CVI is a potential tool in establishing early diagnoses, monitoring disease progression and prognosticating patients. CVI has been reported in existing literature as a robust marker in numerous retinal and choroidal diseases. In this review, we will discuss the current role of CVI with reference to existing literature, and make postulations about its potential and future applications.

Authors+Show Affiliations

Department of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore; Singapore Eye Research Institute, Singapore; Moorfields Eye Hospital, NHS Foundation Trust, London, United Kingdom; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address: rupesh_agrawal@ttsh.com.sg.Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.Medical Research Foundation, Sankara Netralaya, Chennai, India.Department of Ophthalmology, Universidad del Salvador, Buenos Aires, Argentina.Department of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore.Centre for Eye Health, Sydney, New South Wales, Australia; School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia.Department of Ophthalmology, Tan Tock Seng Hospital, NHG Eye Institute, Singapore.Saint Jose Mercy Oakland Hospital, Michigan, USA.Aravind Eye Hospital, Madurai, Tamilnadu, India.Aravind Eye Hospital, Madurai, Tamilnadu, India.Shroff Eye Centre, New Delhi, India.Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.Drishti Eye Institute, Dehradun, India.Department of Ophthalmology, University Clinic Bern, Bern, Switzerland.Department of Ophthalmology & Visual Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.Advanced Eye Centre, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31927136

Citation

Agrawal, Rupesh, et al. "Exploring Choroidal Angioarchitecture in Health and Disease Using Choroidal Vascularity Index." Progress in Retinal and Eye Research, 2020, p. 100829.
Agrawal R, Ding J, Sen P, et al. Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index. Prog Retin Eye Res. 2020.
Agrawal, R., Ding, J., Sen, P., Rousselot, A., Chan, A., Nivison-Smith, L., Wei, X., Mahajan, S., Kim, R., Mishra, C., Agarwal, M., Suh, M. H., Luthra, S., Munk, M. R., Cheung, C. Y., & Gupta, V. (2020). Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index. Progress in Retinal and Eye Research, 100829. https://doi.org/10.1016/j.preteyeres.2020.100829
Agrawal R, et al. Exploring Choroidal Angioarchitecture in Health and Disease Using Choroidal Vascularity Index. Prog Retin Eye Res. 2020 Jan 10;100829. PubMed PMID: 31927136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index. AU - Agrawal,Rupesh, AU - Ding,Jianbin, AU - Sen,Parveen, AU - Rousselot,Andres, AU - Chan,Amy, AU - Nivison-Smith,Lisa, AU - Wei,Xin, AU - Mahajan,Sarakshi, AU - Kim,Ramasamy, AU - Mishra,Chitaranjan, AU - Agarwal,Manisha, AU - Suh,Min Hee, AU - Luthra,Saurabh, AU - Munk,Marion R, AU - Cheung,Carol Y, AU - Gupta,Vishali, AU - ,, Y1 - 2020/01/10/ PY - 2019/10/25/received PY - 2019/12/30/revised PY - 2020/01/04/accepted PY - 2020/1/14/pubmed PY - 2020/1/14/medline PY - 2020/1/14/entrez KW - Age related macular degeneration KW - Artificial intelligence KW - Choroid KW - Choroidal vascularity index KW - Optical coherence tomography KW - Uveitis SP - 100829 EP - 100829 JF - Progress in retinal and eye research JO - Prog Retin Eye Res N2 - The choroid is one of the most vascularized structures of the human body and plays an irreplaceable role in nourishing photoreceptors. As such, choroidal dysfunction is implicated in a multitude of ocular diseases. Studying the choroid can lead to a better understanding of disease pathogenesis, progression and discovery of novel management strategies. However, current research has produced inconsistent findings, partly due to the physical inaccessibility of the choroid and the lack of reliable biomarkers. With the advancements in optical coherence tomography technology, our group has developed a novel quantitative imaging biomarker known as the choroidal vascularity index (CVI), defined as the ratio of vascular area to the total choroidal area. CVI is a potential tool in establishing early diagnoses, monitoring disease progression and prognosticating patients. CVI has been reported in existing literature as a robust marker in numerous retinal and choroidal diseases. In this review, we will discuss the current role of CVI with reference to existing literature, and make postulations about its potential and future applications. SN - 1873-1635 UR - https://www.unboundmedicine.com/medline/citation/31927136/Exploring_choroidal_angioarchitecture_in_health_and_disease_using_choroidal_vascularity_index L2 - https://linkinghub.elsevier.com/retrieve/pii/S1350-9462(20)30001-X DB - PRIME DP - Unbound Medicine ER -
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