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Tremor in Parkinson's Disease May Arise from Interactions of Central Rhythms with Spinal Reflex Loop Oscillations.

Abstract

It is commonly believed that tremor, one of the cardinal signs of Parkinson's disease, is associated with cerebello-thalamo-cortical oscillations set off by the dopamine-depleted basal ganglia networks. The triggering mechanism has been, however, not entirely delineated. Several reports have pointed to the relevance of interactions with peripheral/spinal mechanisms to tremor generation. Investigations of motor unit synchronization and discharge patterns suggested that exaggerated beta-band oscillations may intermittently reach alpha-motoneurons and modulate low-amplitude membrane oscillations due to spinal loop transmission delays. As a result, the spinal reflex loop will oscillate more vigorously and at a lower frequency and, in turn, entrain larger transcortical loops. Motoneurons may thus represent the specific generator "node" in a tremor network encompassing both cerebral and peripheral/spinal recurrent circuits.

Authors+Show Affiliations

Department of Neurology, University of Ioannina, Ioannina, Greece. Akutnahe Rehabilitation, Kantonsspital Baden, Baden/Bad Zurzach, Switzerland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31929120

Citation

Anastasopoulos, Dimitri. "Tremor in Parkinson's Disease May Arise From Interactions of Central Rhythms With Spinal Reflex Loop Oscillations." Journal of Parkinson's Disease, 2020.
Anastasopoulos D. Tremor in Parkinson's Disease May Arise from Interactions of Central Rhythms with Spinal Reflex Loop Oscillations. J Parkinsons Dis. 2020.
Anastasopoulos, D. (2020). Tremor in Parkinson's Disease May Arise from Interactions of Central Rhythms with Spinal Reflex Loop Oscillations. Journal of Parkinson's Disease, doi:10.3233/JPD-191715.
Anastasopoulos D. Tremor in Parkinson's Disease May Arise From Interactions of Central Rhythms With Spinal Reflex Loop Oscillations. J Parkinsons Dis. 2020 Jan 6; PubMed PMID: 31929120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tremor in Parkinson's Disease May Arise from Interactions of Central Rhythms with Spinal Reflex Loop Oscillations. A1 - Anastasopoulos,Dimitri, Y1 - 2020/01/06/ PY - 2020/1/14/pubmed PY - 2020/1/14/medline PY - 2020/1/14/entrez KW - Parkinsonian tremor KW - beta oscillations KW - motor unit synchrony KW - spike doublets JF - Journal of Parkinson's disease JO - J Parkinsons Dis N2 - It is commonly believed that tremor, one of the cardinal signs of Parkinson's disease, is associated with cerebello-thalamo-cortical oscillations set off by the dopamine-depleted basal ganglia networks. The triggering mechanism has been, however, not entirely delineated. Several reports have pointed to the relevance of interactions with peripheral/spinal mechanisms to tremor generation. Investigations of motor unit synchronization and discharge patterns suggested that exaggerated beta-band oscillations may intermittently reach alpha-motoneurons and modulate low-amplitude membrane oscillations due to spinal loop transmission delays. As a result, the spinal reflex loop will oscillate more vigorously and at a lower frequency and, in turn, entrain larger transcortical loops. Motoneurons may thus represent the specific generator "node" in a tremor network encompassing both cerebral and peripheral/spinal recurrent circuits. SN - 1877-718X UR - https://www.unboundmedicine.com/medline/citation/31929120/Tremor_in_Parkinson's_Disease_May_Arise_from_Interactions_of_Central_Rhythms_with_Spinal_Reflex_Loop_Oscillations L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JPD-191715 DB - PRIME DP - Unbound Medicine ER -