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Rapid isolation of benzodiazepines with Sep-Pak C18 cartridges.
J Forensic Sci. 1988 Sep; 33(5):1249-53.JF

Abstract

A rapid method for isolation of various benzodiazepines from human samples with Sep-Pak C18 cartridges before wide-bore capillary gas chromatography is described. The drugs dissolved in alkaline samples were directly applied to the cartridges and eluted with hexane/isopropanol (9:1). The recoveries were excellent for all drugs in urine samples, but were somewhat lower for some drugs in plasma samples. The latter problem could be easily circumvented by using a deproteinization process before their application to the cartridge. We can recommend the Sep-Pak C18 cartridges for isolation of benzodiazepines because of their simplicity and rapidity.

Authors+Show Affiliations

Department of Legal Medicine, Hamamatsu University School of Medicine, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3193081

Citation

Suzuki, O, et al. "Rapid Isolation of Benzodiazepines With Sep-Pak C18 Cartridges." Journal of Forensic Sciences, vol. 33, no. 5, 1988, pp. 1249-53.
Suzuki O, Seno H, Kumazawa T. Rapid isolation of benzodiazepines with Sep-Pak C18 cartridges. J Forensic Sci. 1988;33(5):1249-53.
Suzuki, O., Seno, H., & Kumazawa, T. (1988). Rapid isolation of benzodiazepines with Sep-Pak C18 cartridges. Journal of Forensic Sciences, 33(5), 1249-53.
Suzuki O, Seno H, Kumazawa T. Rapid Isolation of Benzodiazepines With Sep-Pak C18 Cartridges. J Forensic Sci. 1988;33(5):1249-53. PubMed PMID: 3193081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid isolation of benzodiazepines with Sep-Pak C18 cartridges. AU - Suzuki,O, AU - Seno,H, AU - Kumazawa,T, PY - 1988/9/1/pubmed PY - 1988/9/1/medline PY - 1988/9/1/entrez SP - 1249 EP - 53 JF - Journal of forensic sciences JO - J Forensic Sci VL - 33 IS - 5 N2 - A rapid method for isolation of various benzodiazepines from human samples with Sep-Pak C18 cartridges before wide-bore capillary gas chromatography is described. The drugs dissolved in alkaline samples were directly applied to the cartridges and eluted with hexane/isopropanol (9:1). The recoveries were excellent for all drugs in urine samples, but were somewhat lower for some drugs in plasma samples. The latter problem could be easily circumvented by using a deproteinization process before their application to the cartridge. We can recommend the Sep-Pak C18 cartridges for isolation of benzodiazepines because of their simplicity and rapidity. SN - 0022-1198 UR - https://www.unboundmedicine.com/medline/citation/3193081/Rapid_isolation_of_benzodiazepines_with_Sep_Pak_C18_cartridges_ DB - PRIME DP - Unbound Medicine ER -
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