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Ameliorate effects of soybean soluble polysaccharide on adenine-induced chronic renal failure in mice.

Abstract

In the present study, the kidney protection effects of soluble soybean polysaccharide (SSPS) were evaluated. To address the issues, a mice model of Chronic renal failure (CRF) was established by gavage 0.2% (w/w) adenine for 3 weeks. In vivo results showed that SSPS could change the concentrations of blood urea nitrogen (BUN), creatinine (CRE), total protein (TP) and albumin (ALB), thereby affecting kidney function. In addition, Masson histopathology analysis indicated that SSPS could decrease the area of collagen fiber in the kidney tissues of CRF mice. Moreover, the results of mRNA expression and western experiment suggested that SSPS treatment could increase the expression of transforming growth factor-β (TGF-β), Smad3 and P-Smad3, while reduce the expression of α smooth muscle actin (α-SMA) when compared with the model group. These results indicated that SSPS potentially improve kidney function through TGF/Smad pathway in CRF mice.

Authors+Show Affiliations

Microbial Resources and Application Laboratory, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.Microbial Resources and Application Laboratory, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.Microbial Resources and Application Laboratory, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.Microbial Resources and Application Laboratory, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.Microbial Resources and Application Laboratory, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China; School of Resources and Environmental Engineering, Hefei University of Technology, Hefei 230009, China. Electronic address: qianli_huang@aliyun.com.Microbial Resources and Application Laboratory, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China. Electronic address: yeming123@sina.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31931056

Citation

Hou, Guohua, et al. "Ameliorate Effects of Soybean Soluble Polysaccharide On Adenine-induced Chronic Renal Failure in Mice." International Journal of Biological Macromolecules, 2020.
Hou G, Jin M, Ye Z, et al. Ameliorate effects of soybean soluble polysaccharide on adenine-induced chronic renal failure in mice. Int J Biol Macromol. 2020.
Hou, G., Jin, M., Ye, Z., Zhang, X., Huang, Q., & Ye, M. (2020). Ameliorate effects of soybean soluble polysaccharide on adenine-induced chronic renal failure in mice. International Journal of Biological Macromolecules, doi:10.1016/j.ijbiomac.2020.01.095.
Hou G, et al. Ameliorate Effects of Soybean Soluble Polysaccharide On Adenine-induced Chronic Renal Failure in Mice. Int J Biol Macromol. 2020 Jan 10; PubMed PMID: 31931056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorate effects of soybean soluble polysaccharide on adenine-induced chronic renal failure in mice. AU - Hou,Guohua, AU - Jin,Mingzhi, AU - Ye,Ziyang, AU - Zhang,Xinmiao, AU - Huang,Qianli, AU - Ye,Ming, Y1 - 2020/01/10/ PY - 2019/05/06/received PY - 2020/01/08/revised PY - 2020/01/09/accepted PY - 2020/1/14/entrez PY - 2020/1/14/pubmed PY - 2020/1/14/medline KW - Chronic renal failure KW - Renoprotection KW - Soluble soybean polysaccharide JF - International journal of biological macromolecules JO - Int. J. Biol. Macromol. N2 - In the present study, the kidney protection effects of soluble soybean polysaccharide (SSPS) were evaluated. To address the issues, a mice model of Chronic renal failure (CRF) was established by gavage 0.2% (w/w) adenine for 3 weeks. In vivo results showed that SSPS could change the concentrations of blood urea nitrogen (BUN), creatinine (CRE), total protein (TP) and albumin (ALB), thereby affecting kidney function. In addition, Masson histopathology analysis indicated that SSPS could decrease the area of collagen fiber in the kidney tissues of CRF mice. Moreover, the results of mRNA expression and western experiment suggested that SSPS treatment could increase the expression of transforming growth factor-β (TGF-β), Smad3 and P-Smad3, while reduce the expression of α smooth muscle actin (α-SMA) when compared with the model group. These results indicated that SSPS potentially improve kidney function through TGF/Smad pathway in CRF mice. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/31931056/Ameliorate_effects_of_soybean_soluble_polysaccharide_on_adenine-induced_chronic_renal_failure_in_mice L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(19)33339-2 DB - PRIME DP - Unbound Medicine ER -