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Gastric aggressive fibromatosis: report of a case and review of the literature.
Int J Clin Exp Pathol 2019; 12(1):372-377IJ

Abstract

OBJECTIVES

To describe a rare case of aggressive fibromatosis of the stomach and discuss the differential diagnoses.

METHODS

A 47-year-old man presented with nonspecific abdominal pain. Gastroscopy revealed stomach wall swelling. An antral gastrectomy was performed. Histological examination revealed spindle-shaped cells and morphology typical of aggressive fibromatosis. We performed a literature search to identify conditions with features similar to those of aggressive fibromatosis.

RESULTS

Aggressive fibromatosis does not metastasize, but it is locally invasive and has a tendency to relapse; however, our patient has not had recurrence > 1 year after surgery. Aggressive fibromatosis of the stomach may be confused with an inflammatory fibroid polyp, a gastrointestinal stromal tumor, schwannoma, leiomyoma, inflammatory myofibroblastic tumor, scirrhous carcinoma of the stomach, follicular dendritic cell sarcoma, inflammatory malignant fibrous histiocytoma, myofibroma/myofibromatosis, and solitary fibrous tumor of the stomach.

CONCLUSIONS

Aggressive fibromatosis of the stomach is a rare spindle cell tumor that must be differentiated from a variety of conditions.

Authors+Show Affiliations

Department of Pathology, Southern Medical University Shenzhen Hospital Shenzhen, Guangdong, China.Department of Pathology, 159 Hospital of PLA Zhumadian, China.Department of Pathology, 159 Hospital of PLA Zhumadian, China.Shenzhen Polytechnic, School of Electronic and Communication Engineering Shenzhen, Guangdong, China.Shenzhen Polytechnic, School of Electronic and Communication Engineering Shenzhen, Guangdong, China.Department of Pathology, 150 Hospital of PLA Luoyang, China.Department of Pathology, 150 Hospital of PLA Luoyang, China.Department of Pathology, Southern Medical University Shenzhen Hospital Shenzhen, Guangdong, China.Department of Pathology, Southern Medical University Shenzhen Hospital Shenzhen, Guangdong, China.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31933754

Citation

Wang, Yang-Kun, et al. "Gastric Aggressive Fibromatosis: Report of a Case and Review of the Literature." International Journal of Clinical and Experimental Pathology, vol. 12, no. 1, 2019, pp. 372-377.
Wang YK, Jiang B, Yang YC, et al. Gastric aggressive fibromatosis: report of a case and review of the literature. Int J Clin Exp Pathol. 2019;12(1):372-377.
Wang, Y. K., Jiang, B., Yang, Y. C., Wang, S. N., Li, Y. Y., Meng, N. L., ... Li, Z. G. (2019). Gastric aggressive fibromatosis: report of a case and review of the literature. International Journal of Clinical and Experimental Pathology, 12(1), pp. 372-377.
Wang YK, et al. Gastric Aggressive Fibromatosis: Report of a Case and Review of the Literature. Int J Clin Exp Pathol. 2019;12(1):372-377. PubMed PMID: 31933754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric aggressive fibromatosis: report of a case and review of the literature. AU - Wang,Yang-Kun, AU - Jiang,Bo, AU - Yang,Yan-Cheng, AU - Wang,Su-Nan, AU - Li,Ying-Ying, AU - Meng,Nian-Long, AU - Yuan,Xu-Tao, AU - Jiang,Run-De, AU - Li,Zu-Guo, Y1 - 2019/01/01/ PY - 2018/10/24/received PY - 2018/11/23/accepted PY - 2020/1/15/entrez PY - 2020/1/15/pubmed PY - 2020/1/15/medline KW - Gastric tumor KW - aggressive fibromatosis KW - clinicopathological features KW - differential diagnosis KW - immunohistochemistry SP - 372 EP - 377 JF - International journal of clinical and experimental pathology JO - Int J Clin Exp Pathol VL - 12 IS - 1 N2 - OBJECTIVES: To describe a rare case of aggressive fibromatosis of the stomach and discuss the differential diagnoses. METHODS: A 47-year-old man presented with nonspecific abdominal pain. Gastroscopy revealed stomach wall swelling. An antral gastrectomy was performed. Histological examination revealed spindle-shaped cells and morphology typical of aggressive fibromatosis. We performed a literature search to identify conditions with features similar to those of aggressive fibromatosis. RESULTS: Aggressive fibromatosis does not metastasize, but it is locally invasive and has a tendency to relapse; however, our patient has not had recurrence > 1 year after surgery. Aggressive fibromatosis of the stomach may be confused with an inflammatory fibroid polyp, a gastrointestinal stromal tumor, schwannoma, leiomyoma, inflammatory myofibroblastic tumor, scirrhous carcinoma of the stomach, follicular dendritic cell sarcoma, inflammatory malignant fibrous histiocytoma, myofibroma/myofibromatosis, and solitary fibrous tumor of the stomach. CONCLUSIONS: Aggressive fibromatosis of the stomach is a rare spindle cell tumor that must be differentiated from a variety of conditions. SN - 1936-2625 UR - https://www.unboundmedicine.com/medline/citation/31933754/Gastric_aggressive_fibromatosis:_report_of_a_case_and_review_of_the_literature L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31933754/ DB - PRIME DP - Unbound Medicine ER -