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Effects of PM2.5 exposure during gestation on maternal gut microbiota and pregnancy outcomes.
Chemosphere. 2020 May; 247:125879.C

Abstract

A number of studies have reported that fine particulate matter (PM2.5) exposure is associated with adverse pregnancy outcomes. Moreover, PM2.5 exposure contributes to changes of gut microbiota. However, influences of PM2.5 exposure during gestation on maternal gut microbiota and pregnancy outcomes were not well understood. Here we performed a study using mice models. Dams were exposed to PM2.5 suspension by intratracheal instillation on gestational day (GD) 3, 6, 9, 12 and 15. Pregnancy outcomes, maternal gut microbiota and short chain fatty acids on GD 18 were all measured. The fetal body weight of PM2.5 group was significantly lower than that of control group (p < 0.05). Meanwhile, the fetal body length of PM2.5 group was significantly shorter than that of control group (p < 0.05). The Shannon or Simpson index of PM2.5 group were higher than that of control group (p < 0.05). At the phyla level, compared to dams in control group, mice in the PM2.5 group had higher ratio of phyla Proteobacteria, Candidatus Saccharibacteria and Fusobacteria and lower ratio of phyla Acidobacteria, Gemmatimonadetes and Deferribacteres in the gut. Compared with control group, the concentration of isobutyric acid was higher in PM2.5 group, but butyric acid concentration was lower in PM2.5 group (p < 0.05). These findings suggested that prenatal exposure to PM2.5 had an effect on birth weight of fetus. Meanwhile, PM2.5 tracheal exposure during gestation caused changes in the distribution and structure of gut microbiota of dams.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100083, China.Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100083, China.Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100083, China.Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100083, China.Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100083, China.Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100083, China.Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100083, China.Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, 100083, China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Beijing, 100083, China. Electronic address: xuyajun@bjmu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31935575

Citation

Liu, Wei, et al. "Effects of PM2.5 Exposure During Gestation On Maternal Gut Microbiota and Pregnancy Outcomes." Chemosphere, vol. 247, 2020, p. 125879.
Liu W, Zhou Y, Yong Li , et al. Effects of PM2.5 exposure during gestation on maternal gut microbiota and pregnancy outcomes. Chemosphere. 2020;247:125879.
Liu, W., Zhou, Y., Yong Li, ., Qin, Y., Yu, L., Li, R., Chen, Y., & Xu, Y. (2020). Effects of PM2.5 exposure during gestation on maternal gut microbiota and pregnancy outcomes. Chemosphere, 247, 125879. https://doi.org/10.1016/j.chemosphere.2020.125879
Liu W, et al. Effects of PM2.5 Exposure During Gestation On Maternal Gut Microbiota and Pregnancy Outcomes. Chemosphere. 2020;247:125879. PubMed PMID: 31935575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of PM2.5 exposure during gestation on maternal gut microbiota and pregnancy outcomes. AU - Liu,Wei, AU - Zhou,Yalin, AU - Yong Li,, AU - Qin,Yong, AU - Yu,Lanlan, AU - Li,Ruijun, AU - Chen,Yuhan, AU - Xu,Yajun, Y1 - 2020/01/09/ PY - 2019/11/06/received PY - 2020/01/06/revised PY - 2020/01/08/accepted PY - 2020/1/15/pubmed PY - 2020/4/23/medline PY - 2020/1/15/entrez KW - Gut microbiota KW - PM(2.5) KW - Pregnancy outcomes KW - Short chain fatty acids SP - 125879 EP - 125879 JF - Chemosphere JO - Chemosphere VL - 247 N2 - A number of studies have reported that fine particulate matter (PM2.5) exposure is associated with adverse pregnancy outcomes. Moreover, PM2.5 exposure contributes to changes of gut microbiota. However, influences of PM2.5 exposure during gestation on maternal gut microbiota and pregnancy outcomes were not well understood. Here we performed a study using mice models. Dams were exposed to PM2.5 suspension by intratracheal instillation on gestational day (GD) 3, 6, 9, 12 and 15. Pregnancy outcomes, maternal gut microbiota and short chain fatty acids on GD 18 were all measured. The fetal body weight of PM2.5 group was significantly lower than that of control group (p < 0.05). Meanwhile, the fetal body length of PM2.5 group was significantly shorter than that of control group (p < 0.05). The Shannon or Simpson index of PM2.5 group were higher than that of control group (p < 0.05). At the phyla level, compared to dams in control group, mice in the PM2.5 group had higher ratio of phyla Proteobacteria, Candidatus Saccharibacteria and Fusobacteria and lower ratio of phyla Acidobacteria, Gemmatimonadetes and Deferribacteres in the gut. Compared with control group, the concentration of isobutyric acid was higher in PM2.5 group, but butyric acid concentration was lower in PM2.5 group (p < 0.05). These findings suggested that prenatal exposure to PM2.5 had an effect on birth weight of fetus. Meanwhile, PM2.5 tracheal exposure during gestation caused changes in the distribution and structure of gut microbiota of dams. SN - 1879-1298 UR - https://www.unboundmedicine.com/medline/citation/31935575/Effects_of_PM2_5_exposure_during_gestation_on_maternal_gut_microbiota_and_pregnancy_outcomes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0045-6535(20)30071-0 DB - PRIME DP - Unbound Medicine ER -