TY - JOUR T1 - Mitophagy in Alzheimer's Disease and Other Age-Related Neurodegenerative Diseases. AU - Cai,Qian, AU - Jeong,Yu Young, Y1 - 2020/01/08/ PY - 2019/12/19/received PY - 2020/01/03/revised PY - 2020/01/05/accepted PY - 2020/1/16/entrez PY - 2020/1/16/pubmed PY - 2021/2/5/medline KW - Alzheimer’s disease KW - Huntington’s disease KW - Parkinson’s disease KW - aging KW - amyotrophic lateral sclerosis KW - lysosome KW - mitochondrial dynamics KW - mitochondrial quality control KW - mitophagosome KW - mitophagy JF - Cells JO - Cells VL - 9 IS - 1 N2 - Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. Mitochondria are the main cellular energy powerhouses, supplying most of ATP by oxidative phosphorylation, which is required to fuel essential neuronal functions. Efficient removal of aged and dysfunctional mitochondria through mitophagy, a cargo-selective autophagy, is crucial for mitochondrial maintenance and neuronal health. Mechanistic studies into mitophagy have highlighted an integrated and elaborate cellular network that can regulate mitochondrial turnover. In this review, we provide an updated overview of the recent discoveries and advancements on the mitophagy pathways and discuss the molecular mechanisms underlying mitophagy defects in Alzheimer's disease and other age-related neurodegenerative diseases, as well as the therapeutic potential of mitophagy-enhancing strategies to combat these disorders. SN - 2073-4409 UR - https://www.unboundmedicine.com/medline/citation/31936292/Mitophagy_in_Alzheimer's_Disease_and_Other_Age_Related_Neurodegenerative_Diseases_ DB - PRIME DP - Unbound Medicine ER -