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Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer?
Cancers (Basel) 2020; 12(1)C

Abstract

β-glucans represent a heterogeneous group of naturally occurring and biologically active polysaccharides found in many kinds of edible mushrooms, baker's yeast, cereals and seaweeds, whose health-promoting effects have been known since ancient times. These compounds can be taken orally as food supplements or as part of daily diets, and are safe to use, nonimmunogenic and well tolerated. A main feature of β-glucans is their capacity to function as biological response modifiers, exerting regulatory effects on inflammation and shaping the effector functions of different innate and adaptive immunity cell populations. The potential to interfere with processes involved in the development or control of cancer makes β-glucans interesting candidates as adjuvants in antitumor therapies as well as in cancer prevention strategies. Here, the regulatory effects of dietary β-glucans on human innate immunity cells are reviewed and their potential role in cancer control is discussed.

Authors+Show Affiliations

Center for Gender-specific Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.Center for Gender-specific Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.Center for Gender-specific Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31936360

Citation

Del Cornò, Manuela, et al. "Shaping the Innate Immune Response By Dietary Glucans: Any Role in the Control of Cancer?" Cancers, vol. 12, no. 1, 2020.
Del Cornò M, Gessani S, Conti L. Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer? Cancers (Basel). 2020;12(1).
Del Cornò, M., Gessani, S., & Conti, L. (2020). Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer? Cancers, 12(1), doi:10.3390/cancers12010155.
Del Cornò M, Gessani S, Conti L. Shaping the Innate Immune Response By Dietary Glucans: Any Role in the Control of Cancer. Cancers (Basel). 2020 Jan 8;12(1) PubMed PMID: 31936360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer? AU - Del Cornò,Manuela, AU - Gessani,Sandra, AU - Conti,Lucia, Y1 - 2020/01/08/ PY - 2019/12/05/received PY - 2019/12/20/revised PY - 2019/12/20/accepted PY - 2020/1/16/entrez KW - cancer KW - immunotherapy KW - innate immunity KW - nutrition KW - β-glucans JF - Cancers JO - Cancers (Basel) VL - 12 IS - 1 N2 - β-glucans represent a heterogeneous group of naturally occurring and biologically active polysaccharides found in many kinds of edible mushrooms, baker's yeast, cereals and seaweeds, whose health-promoting effects have been known since ancient times. These compounds can be taken orally as food supplements or as part of daily diets, and are safe to use, nonimmunogenic and well tolerated. A main feature of β-glucans is their capacity to function as biological response modifiers, exerting regulatory effects on inflammation and shaping the effector functions of different innate and adaptive immunity cell populations. The potential to interfere with processes involved in the development or control of cancer makes β-glucans interesting candidates as adjuvants in antitumor therapies as well as in cancer prevention strategies. Here, the regulatory effects of dietary β-glucans on human innate immunity cells are reviewed and their potential role in cancer control is discussed. SN - 2072-6694 UR - https://www.unboundmedicine.com/medline/citation/31936360/Shaping_the_Innate_Immune_Response_by_Dietary_Glucans:_Any_Role_in_the_Control_of_Cancer L2 - http://www.mdpi.com/resolver?pii=cancers12010155 DB - PRIME DP - Unbound Medicine ER -