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The Effect of Donor Human Milk Fortification on The Adhesion of Probiotics In Vitro.
Nutrients. 2020 Jan 09; 12(1)N

Abstract

Preterm delivery complications are the primary cause of death among children under the age of five. Preventive strategies include the use of pasteurized donor human milk (DHM), its fortification with human milk fortifiers (protein supplements), and supplementation with probiotics. Our aim was to examine the impact of DHM and fortified DHM (FDHM) on the mucus adhesion properties of two widely used probiotics. The study covered two forms of human milk fortifier, liquid and powdered, with or without probiotics and storage at 4 °C for 24 h. To test the adhesion properties of the probiotic strains, DHM+probiotics and FDHM+probiotics were prepared and added to immobilized mucus isolated from the stool of healthy Finnish infants. The probiotic adhesion was then measured by liquid scintillation. Our results suggest that addition of liquid or powdered human milk fortifier in donor human milk had no impact on probiotic adhesion. In addition, given the increased adhesion of probiotics suspended in buffer, other matrices should be further studied. These factors need to be considered when designing future intervention strategies using probiotics in preterm infants.

Authors+Show Affiliations

Functional Foods Forum, Faculty of Medicine, University of Turku, Itäinen Pitkäkatu 4A, 20520 Turku, Finland.Functional Foods Forum, Faculty of Medicine, University of Turku, Itäinen Pitkäkatu 4A, 20520 Turku, Finland.DuPont Nutrition and Biosciences, Sokeritehtaantie 20, 02460 Kantvik, Finland.Unit of Biostatistics, Department of Clinical Medicine University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland.Department of Pediatrics, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland.Functional Foods Forum, Faculty of Medicine, University of Turku, Itäinen Pitkäkatu 4A, 20520 Turku, Finland.Department of Pediatrics, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31936487

Citation

Mantziari, Anastasia, et al. "The Effect of Donor Human Milk Fortification On the Adhesion of Probiotics in Vitro." Nutrients, vol. 12, no. 1, 2020.
Mantziari A, Tölkkö S, Ouwehand AC, et al. The Effect of Donor Human Milk Fortification on The Adhesion of Probiotics In Vitro. Nutrients. 2020;12(1).
Mantziari, A., Tölkkö, S., Ouwehand, A. C., Löyttyniemi, E., Isolauri, E., Salminen, S., & Rautava, S. (2020). The Effect of Donor Human Milk Fortification on The Adhesion of Probiotics In Vitro. Nutrients, 12(1). https://doi.org/10.3390/nu12010182
Mantziari A, et al. The Effect of Donor Human Milk Fortification On the Adhesion of Probiotics in Vitro. Nutrients. 2020 Jan 9;12(1) PubMed PMID: 31936487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effect of Donor Human Milk Fortification on The Adhesion of Probiotics In Vitro. AU - Mantziari,Anastasia, AU - Tölkkö,Satu, AU - Ouwehand,Artur C, AU - Löyttyniemi,Eliisa, AU - Isolauri,Erika, AU - Salminen,Seppo, AU - Rautava,Samuli, Y1 - 2020/01/09/ PY - 2019/12/05/received PY - 2020/01/01/revised PY - 2020/01/04/accepted PY - 2020/1/16/entrez PY - 2020/1/16/pubmed PY - 2020/1/16/medline KW - Bifidobacterium animalis subsp. lactis Bb12 KW - Lactobacillus rhamnosus GG KW - human milk fortifier KW - infant nutrition KW - preterm infant JF - Nutrients JO - Nutrients VL - 12 IS - 1 N2 - Preterm delivery complications are the primary cause of death among children under the age of five. Preventive strategies include the use of pasteurized donor human milk (DHM), its fortification with human milk fortifiers (protein supplements), and supplementation with probiotics. Our aim was to examine the impact of DHM and fortified DHM (FDHM) on the mucus adhesion properties of two widely used probiotics. The study covered two forms of human milk fortifier, liquid and powdered, with or without probiotics and storage at 4 °C for 24 h. To test the adhesion properties of the probiotic strains, DHM+probiotics and FDHM+probiotics were prepared and added to immobilized mucus isolated from the stool of healthy Finnish infants. The probiotic adhesion was then measured by liquid scintillation. Our results suggest that addition of liquid or powdered human milk fortifier in donor human milk had no impact on probiotic adhesion. In addition, given the increased adhesion of probiotics suspended in buffer, other matrices should be further studied. These factors need to be considered when designing future intervention strategies using probiotics in preterm infants. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/31936487/The_Effect_of_Donor_Human_Milk_Fortification_on_The_Adhesion_of_Probiotics_In_Vitro L2 - https://www.mdpi.com/resolver?pii=nu12010182 DB - PRIME DP - Unbound Medicine ER -
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