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The Unknown Health Burden of Herpes Zoster Hospitalizations: The Effect on Chronic Disease Course in Adult Patients ≥50 Years.
Vaccines (Basel) 2020; 8(1)V

Abstract

The effect of severe Herpes Zoster (HZ) on chronic diseases is a component of the real burden of this vaccine-preventable disease that is not commonly considered. A retrospective cohort study was conducted to assess the health burden of severe HZ in adults ≥50 years residing in Liguria Region from 2015 to 2017. Subjects hospitalized with and without HZ were matched (1:6 ratio). 437 subjects in the HZ cohort and 2622 subjects in the non-HZ cohort were enrolled. Previous immunodeficiency, autoimmune, and rare diseases are identified as main chronic conditions related to HZ hospitalization. Higher incidences of autoimmune (1.4% vs. 0.22%, p = 0.002) and gastrointestinal (7.04% vs. 3.62%, p = 0.015) diseases after hospitalization were observed in the HZ cohort compared to the non-HZ cohort. Significantly higher incidences were found after hospitalization versus the previous period for cardiovascular diseases (11.17% vs. 2.09%, p < 0.001), cerebral vasculopathy (6.13% vs. 0.60%, p < 0.001), non-arrhythmic myocardiopathy (4.31% vs. 0.59%, p = 0.002), and neuropathy (2.62% vs. 0.56%, p = 0.033). The HZ cohort showed a relative risk 10-fold higher for cerebral vasculopathy, 5-fold higher for cardiovascular diseases, and 7-fold higher for non-arrhythmic myocardiopathy. HZ causes a substantial impact on the chronic conditions. These data could suggest an implementation of HZ vaccination programs in the elderly and in high-risk groups.

Authors+Show Affiliations

Department of Health Sciences, University of Genoa, Via Antonio Pastore 1, 16132 Genoa, Italy. A.Li.Sa., Liguria Health Authority, Piazza della Vittoria 15, 16121 Genoa, Italy.A.Li.Sa., Liguria Health Authority, Piazza della Vittoria 15, 16121 Genoa, Italy.Department of Health Sciences, University of Genoa, Via Antonio Pastore 1, 16132 Genoa, Italy. A.Li.Sa., Liguria Health Authority, Piazza della Vittoria 15, 16121 Genoa, Italy.A.Li.Sa., Liguria Health Authority, Piazza della Vittoria 15, 16121 Genoa, Italy.Department of Health Sciences, University of Genoa, Via Antonio Pastore 1, 16132 Genoa, Italy. Hygiene Unit, San Martino Polyclinic Hospital, Largo Rosanna Benzi 10, 16132 Genoa, Italy.Department of Health Sciences, University of Genoa, Via Antonio Pastore 1, 16132 Genoa, Italy.Liguria Digitale S.p.A., Via Enrico Melen 77, 16152 Genoa, Italy.Liguria Digitale S.p.A., Via Enrico Melen 77, 16152 Genoa, Italy.Department of Health Sciences, University of Genoa, Via Antonio Pastore 1, 16132 Genoa, Italy. Hygiene Unit, San Martino Polyclinic Hospital, Largo Rosanna Benzi 10, 16132 Genoa, Italy.Department of Health Sciences, University of Genoa, Via Antonio Pastore 1, 16132 Genoa, Italy. A.Li.Sa., Liguria Health Authority, Piazza della Vittoria 15, 16121 Genoa, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31936724

Citation

Piazza, Maria Francesca, et al. "The Unknown Health Burden of Herpes Zoster Hospitalizations: the Effect On Chronic Disease Course in Adult Patients ≥50 Years." Vaccines, vol. 8, no. 1, 2020.
Piazza MF, Paganino C, Amicizia D, et al. The Unknown Health Burden of Herpes Zoster Hospitalizations: The Effect on Chronic Disease Course in Adult Patients ≥50 Years. Vaccines (Basel). 2020;8(1).
Piazza, M. F., Paganino, C., Amicizia, D., Trucchi, C., Orsi, A., Astengo, M., ... Ansaldi, F. (2020). The Unknown Health Burden of Herpes Zoster Hospitalizations: The Effect on Chronic Disease Course in Adult Patients ≥50 Years. Vaccines, 8(1), doi:10.3390/vaccines8010020.
Piazza MF, et al. The Unknown Health Burden of Herpes Zoster Hospitalizations: the Effect On Chronic Disease Course in Adult Patients ≥50 Years. Vaccines (Basel). 2020 Jan 10;8(1) PubMed PMID: 31936724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Unknown Health Burden of Herpes Zoster Hospitalizations: The Effect on Chronic Disease Course in Adult Patients ≥50 Years. AU - Piazza,Maria Francesca, AU - Paganino,Chiara, AU - Amicizia,Daniela, AU - Trucchi,Cecilia, AU - Orsi,Andrea, AU - Astengo,Matteo, AU - Romairone,Paolo, AU - Simonetti,Simona, AU - Icardi,Giancarlo, AU - Ansaldi,Filippo, Y1 - 2020/01/10/ PY - 2019/12/27/received PY - 2020/01/08/revised PY - 2020/01/08/accepted PY - 2020/1/16/entrez KW - Herpes Zoster KW - cerebral vasculopathy KW - chronic diseases KW - elderly KW - high-risk groups KW - hospitalizations KW - readmissions and drug therapy KW - risk factors JF - Vaccines JO - Vaccines (Basel) VL - 8 IS - 1 N2 - The effect of severe Herpes Zoster (HZ) on chronic diseases is a component of the real burden of this vaccine-preventable disease that is not commonly considered. A retrospective cohort study was conducted to assess the health burden of severe HZ in adults ≥50 years residing in Liguria Region from 2015 to 2017. Subjects hospitalized with and without HZ were matched (1:6 ratio). 437 subjects in the HZ cohort and 2622 subjects in the non-HZ cohort were enrolled. Previous immunodeficiency, autoimmune, and rare diseases are identified as main chronic conditions related to HZ hospitalization. Higher incidences of autoimmune (1.4% vs. 0.22%, p = 0.002) and gastrointestinal (7.04% vs. 3.62%, p = 0.015) diseases after hospitalization were observed in the HZ cohort compared to the non-HZ cohort. Significantly higher incidences were found after hospitalization versus the previous period for cardiovascular diseases (11.17% vs. 2.09%, p < 0.001), cerebral vasculopathy (6.13% vs. 0.60%, p < 0.001), non-arrhythmic myocardiopathy (4.31% vs. 0.59%, p = 0.002), and neuropathy (2.62% vs. 0.56%, p = 0.033). The HZ cohort showed a relative risk 10-fold higher for cerebral vasculopathy, 5-fold higher for cardiovascular diseases, and 7-fold higher for non-arrhythmic myocardiopathy. HZ causes a substantial impact on the chronic conditions. These data could suggest an implementation of HZ vaccination programs in the elderly and in high-risk groups. SN - 2076-393X UR - https://www.unboundmedicine.com/medline/citation/31936724/The_Unknown_Health_Burden_of_Herpes_Zoster_Hospitalizations:_The_Effect_on_Chronic_Disease_Course_in_Adult_Patients_≥50_Years L2 - http://www.mdpi.com/resolver?pii=vaccines8010020 DB - PRIME DP - Unbound Medicine ER -