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An Unusual Presentation of a Patient with Leg Ulcers: A Case Report.
Cureus. 2019 Dec 05; 11(12):e6293.C

Abstract

Leg ulcers have been a common presentation in clinics; disruptions in the mechanism of ulcer healing are vascular insufficiency, anemia, metabolic disturbances, neuropathy, and autoimmunity. The term 'non-transfusion-dependent thalassemia' encompasses the milder forms of thalassemia traits that require intermittent or no transfusion at all, and are mostly associated with leg ulcers. We present the case of a 19-year-old female with beta-thalassemia major who presented with non-healing leg ulcers and anemia. The clinical findings and lab evidence suggested hemolytic anemia evidenced by pathologic fractures, hepato-splenomegaly, and normal iron studies. Hemoglobin electrophoresis confirmed beta-thalassemia major with its complications including adrenal insufficiency and pathological fractures, all of which remained well compensated till the second decade of life.

Authors+Show Affiliations

Internal Medicine, University College of Medicine, University of Lahore, Lahore, PAK.Internal Medicine, University College of Medicine, University of Lahore, Lahore, PAK.Internal Medicine, Jinnah Hospital, Allama Iqbal Medical College, Lahore, PAK.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31938587

Citation

Zafar, Sana, et al. "An Unusual Presentation of a Patient With Leg Ulcers: a Case Report." Cureus, vol. 11, no. 12, 2019, pp. e6293.
Zafar S, Saleem K, Rashid A. An Unusual Presentation of a Patient with Leg Ulcers: A Case Report. Cureus. 2019;11(12):e6293.
Zafar, S., Saleem, K., & Rashid, A. (2019). An Unusual Presentation of a Patient with Leg Ulcers: A Case Report. Cureus, 11(12), e6293. https://doi.org/10.7759/cureus.6293
Zafar S, Saleem K, Rashid A. An Unusual Presentation of a Patient With Leg Ulcers: a Case Report. Cureus. 2019 Dec 5;11(12):e6293. PubMed PMID: 31938587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An Unusual Presentation of a Patient with Leg Ulcers: A Case Report. AU - Zafar,Sana, AU - Saleem,Khurram, AU - Rashid,Aqeela, Y1 - 2019/12/05/ PY - 2020/1/16/entrez PY - 2020/1/16/pubmed PY - 2020/1/16/medline KW - anemia KW - leg ulcers KW - non transfusion dependent KW - thalassemia major SP - e6293 EP - e6293 JF - Cureus JO - Cureus VL - 11 IS - 12 N2 - Leg ulcers have been a common presentation in clinics; disruptions in the mechanism of ulcer healing are vascular insufficiency, anemia, metabolic disturbances, neuropathy, and autoimmunity. The term 'non-transfusion-dependent thalassemia' encompasses the milder forms of thalassemia traits that require intermittent or no transfusion at all, and are mostly associated with leg ulcers. We present the case of a 19-year-old female with beta-thalassemia major who presented with non-healing leg ulcers and anemia. The clinical findings and lab evidence suggested hemolytic anemia evidenced by pathologic fractures, hepato-splenomegaly, and normal iron studies. Hemoglobin electrophoresis confirmed beta-thalassemia major with its complications including adrenal insufficiency and pathological fractures, all of which remained well compensated till the second decade of life. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/31938587/An_Unusual_Presentation_of_a_Patient_with_Leg_Ulcers:_A_Case_Report L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31938587/ DB - PRIME DP - Unbound Medicine ER -
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