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Antibody Complexes.
Subcell Biochem 2019; 93:23-51SB

Abstract

Monoclonal based therapeutics have always been looked at as a futuristic natural way we could take care of pathogens and many diseases. However, in order to develop, establish and realize monoclonal based therapy we need to understand how the immune system contains or kill pathogens. Antibody complexes serve the means to decode this black box. We have discussed examples of antibody complexes both at biochemical and structural levels to understand and appreciate how discoveries in the field of antibody complexes have started to decoded mechanism of viral invasion and create potential vaccine targets against many pathogens. Antibody complexes have made advancement in our knowledge about the molecular interaction between antibody and antigen. It has also led to identification of potent protective monoclonal antibodies. Further use of selective combination of monoclonal antibodies have provided improved protection against deadly diseases. The administration of newly designed and improved immunogen has been used as potential vaccine. Therefore, antibody complexes are important tools to develop new vaccine targets and design an improved combination of monoclonal antibodies for passive immunization or protection with very little or no side effects.

Authors+Show Affiliations

Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan. ulf.skoglund@oist.jp.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31939148

Citation

Akhouri, Reetesh Raj, et al. "Antibody Complexes." Sub-cellular Biochemistry, vol. 93, 2019, pp. 23-51.
Akhouri RR, Öfverstedt LG, Wilken G, et al. Antibody Complexes. Subcell Biochem. 2019;93:23-51.
Akhouri, R. R., Öfverstedt, L. G., Wilken, G., & Skoglund, U. (2019). Antibody Complexes. Sub-cellular Biochemistry, 93, pp. 23-51. doi:10.1007/978-3-030-28151-9_2.
Akhouri RR, et al. Antibody Complexes. Subcell Biochem. 2019;93:23-51. PubMed PMID: 31939148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibody Complexes. AU - Akhouri,Reetesh Raj, AU - Öfverstedt,Lars-Göran, AU - Wilken,Gunnar, AU - Skoglund,Ulf, PY - 2020/1/16/entrez PY - 2020/1/16/pubmed PY - 2020/1/16/medline KW - Antibody KW - Immunization KW - Immunogen KW - Monoclonal antibody KW - Therapeutics KW - Vaccine SP - 23 EP - 51 JF - Sub-cellular biochemistry JO - Subcell. Biochem. VL - 93 N2 - Monoclonal based therapeutics have always been looked at as a futuristic natural way we could take care of pathogens and many diseases. However, in order to develop, establish and realize monoclonal based therapy we need to understand how the immune system contains or kill pathogens. Antibody complexes serve the means to decode this black box. We have discussed examples of antibody complexes both at biochemical and structural levels to understand and appreciate how discoveries in the field of antibody complexes have started to decoded mechanism of viral invasion and create potential vaccine targets against many pathogens. Antibody complexes have made advancement in our knowledge about the molecular interaction between antibody and antigen. It has also led to identification of potent protective monoclonal antibodies. Further use of selective combination of monoclonal antibodies have provided improved protection against deadly diseases. The administration of newly designed and improved immunogen has been used as potential vaccine. Therefore, antibody complexes are important tools to develop new vaccine targets and design an improved combination of monoclonal antibodies for passive immunization or protection with very little or no side effects. SN - 0306-0225 UR - https://www.unboundmedicine.com/medline/citation/31939148/Antibody_Complexes L2 - https://dx.doi.org/10.1007/978-3-030-28151-9_2 DB - PRIME DP - Unbound Medicine ER -