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Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis.
Nutr Rev. 2020 Jan 06 [Online ahead of print]NR

Abstract

CONTEXT

Clinical trials examining the cardiovascular protective effects of quercetin in humans have reported conflicting results.

OBJECTIVE

The aim of this systematic review was to summarize evidence of the effects of quercetin supplementation on plasma lipid profiles, blood pressure (BP), and glucose levels in humans by performing a meta-analysis of randomized controlled trials.

DATA SOURCES

MEDLINE, Embase, and Scopus databases were searched electronically from their inception to July 2018 to identify randomized controlled trials that assessed the impact of quercetin on lipid profiles, BP, and glucose levels.

STUDY SELECTION

Randomized controlled trials assessing the effects of quercetin or a standardized quercetin-enriched extract on plasma lipid profiles, BP, and glucose levels in humans were eligible for inclusion.

DATA EXTRACTION

A random-effects model was used for data analysis. Continuous variables were expressed as weighted mean differences (WMDs) and 95%CIs. Subgroup analyses were conducted to explore possible influences of study characteristics. Sensitivity analyses were also performed, as were analyses of publication bias.

RESULTS

Seventeen trials (n = 896 participants total) were included in the overall analysis. Pooled results showed that quercetin significantly lowered both systolic BP (WMD, -3.09 mmHg; 95%CI, -4.59 to -1.59; P = 0.0001) and diastolic BP (WMD, -2.86 mmHg; 95%CI, -5.09 to -0.63; P = 0.01). Neither lipid profiles nor glucose concentrations changed significantly. In subgroup analyses, significant changes in high-density lipoprotein cholesterol and triglycerides were observed in trials with a parallel design and in which participants consumed quercetin for 8 weeks or more.

CONCLUSION

Quercetin intake resulted in significantly decreased BP in humans. Moreover, participants who consumed quercetin for 8 weeks or more showed significantly changed levels of high-density lipoprotein cholesterol and triglycerides in trials with a parallel design.

Authors+Show Affiliations

Department of Clinical Pharmacy, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.Department of Gynaecology, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.Department of Oncology, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.Department of Laboratory, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31940027

Citation

Huang, Haohai, et al. "Effect of Quercetin Supplementation On Plasma Lipid Profiles, Blood Pressure, and Glucose Levels: a Systematic Review and Meta-analysis." Nutrition Reviews, 2020.
Huang H, Liao D, Dong Y, et al. Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis. Nutr Rev. 2020.
Huang, H., Liao, D., Dong, Y., & Pu, R. (2020). Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis. Nutrition Reviews. https://doi.org/10.1093/nutrit/nuz071
Huang H, et al. Effect of Quercetin Supplementation On Plasma Lipid Profiles, Blood Pressure, and Glucose Levels: a Systematic Review and Meta-analysis. Nutr Rev. 2020 Jan 6; PubMed PMID: 31940027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis. AU - Huang,Haohai, AU - Liao,Dan, AU - Dong,Yong, AU - Pu,Rong, Y1 - 2020/01/06/ PY - 2020/1/16/entrez KW - CVD KW - blood glucose KW - blood pressure KW - lipid KW - quercetin JF - Nutrition reviews JO - Nutr. Rev. N2 - CONTEXT: Clinical trials examining the cardiovascular protective effects of quercetin in humans have reported conflicting results. OBJECTIVE: The aim of this systematic review was to summarize evidence of the effects of quercetin supplementation on plasma lipid profiles, blood pressure (BP), and glucose levels in humans by performing a meta-analysis of randomized controlled trials. DATA SOURCES: MEDLINE, Embase, and Scopus databases were searched electronically from their inception to July 2018 to identify randomized controlled trials that assessed the impact of quercetin on lipid profiles, BP, and glucose levels. STUDY SELECTION: Randomized controlled trials assessing the effects of quercetin or a standardized quercetin-enriched extract on plasma lipid profiles, BP, and glucose levels in humans were eligible for inclusion. DATA EXTRACTION: A random-effects model was used for data analysis. Continuous variables were expressed as weighted mean differences (WMDs) and 95%CIs. Subgroup analyses were conducted to explore possible influences of study characteristics. Sensitivity analyses were also performed, as were analyses of publication bias. RESULTS: Seventeen trials (n = 896 participants total) were included in the overall analysis. Pooled results showed that quercetin significantly lowered both systolic BP (WMD, -3.09 mmHg; 95%CI, -4.59 to -1.59; P = 0.0001) and diastolic BP (WMD, -2.86 mmHg; 95%CI, -5.09 to -0.63; P = 0.01). Neither lipid profiles nor glucose concentrations changed significantly. In subgroup analyses, significant changes in high-density lipoprotein cholesterol and triglycerides were observed in trials with a parallel design and in which participants consumed quercetin for 8 weeks or more. CONCLUSION: Quercetin intake resulted in significantly decreased BP in humans. Moreover, participants who consumed quercetin for 8 weeks or more showed significantly changed levels of high-density lipoprotein cholesterol and triglycerides in trials with a parallel design. SN - 1753-4887 UR - https://www.unboundmedicine.com/medline/citation/31940027/Effect_of_quercetin_supplementation_on_plasma_lipid_profiles_blood_pressure_and_glucose_levels:_a_systematic_review_and_meta_analysis_ L2 - https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1093/nutrit/nuz071 DB - PRIME DP - Unbound Medicine ER -
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