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Influenza vaccination reduces dementia in patients with chronic obstructive pulmonary disease: a nationwide cohort study.
J Investig Med. 2020 Apr; 68(4):838-845.JI

Abstract

This study aimed to explore the protective potential of influenza vaccination against occurrence of dementia in patients with chronic obstructive pulmonary disease (COPD), who are expected to be more vulnerable to influenza infection. This nationwide retrospective cohort study enrolled patients with COPD (aged ≥60 years) from 1 January 2001 to 31 December 2012 by using the Taiwan National Health Insurance Research Database. By applying time-dependent Cox proportional hazard model, we used multivariate analysis to calculate the adjusted HR (aHR) with 95% CI of dementia in relation to influenza vaccination among patients with COPD. Besides, patients were partitioned into four groups according to the vaccination number (unvaccinated, 1, 2-3 and ≥4 total vaccinations) to investigate the dose-response effect of vaccinations on the dementia incidence. This cohort study included 19 848 patients with COPD, and 45% of them received influenza vaccination. The aHR of dementia was 0.68 (95% CI: 0.62 to 0.74, p<0.001) comparing vaccinated patients with unvaccinated ones. Furthermore, there was a trend of dementia risk reduction with the vaccination number. For patients who received 2-3 vaccinations, the aHR was 0.81 (95% CI: 0.73 to 0.90), and for those received 4 vaccinations, the aHR was 0.44 (95% CI: 0.40 to 0.50), with p for trend <0.001. In conclusion, annual influenza vaccination can reduce the risk of dementia in patient with COPD in a dose-dependent manner.

Authors+Show Affiliations

Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan. International Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.Department of Dermatology, Chang Gung Memorial Hospital, Linko, Taoyuan, Taiwan. College of Medicine, Chang Gung University, Taoyuan, Taiwan.Division of Cardiovascular Medicine, Department of Internal Medicine, Taipei Medical University Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan.Division of Cardiovascular Medicine, Department of Internal Medicine, Taipei Medical University Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan leekangyun@tmu.edu.tw liumdcv@tmu.edu.tw. Division of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan leekangyun@tmu.edu.tw liumdcv@tmu.edu.tw. Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31941664

Citation

Luo, Ching-Shan, et al. "Influenza Vaccination Reduces Dementia in Patients With Chronic Obstructive Pulmonary Disease: a Nationwide Cohort Study." Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research, vol. 68, no. 4, 2020, pp. 838-845.
Luo CS, Chi CC, Fang YA, et al. Influenza vaccination reduces dementia in patients with chronic obstructive pulmonary disease: a nationwide cohort study. J Investig Med. 2020;68(4):838-845.
Luo, C. S., Chi, C. C., Fang, Y. A., Liu, J. C., & Lee, K. Y. (2020). Influenza vaccination reduces dementia in patients with chronic obstructive pulmonary disease: a nationwide cohort study. Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research, 68(4), 838-845. https://doi.org/10.1136/jim-2019-001155
Luo CS, et al. Influenza Vaccination Reduces Dementia in Patients With Chronic Obstructive Pulmonary Disease: a Nationwide Cohort Study. J Investig Med. 2020;68(4):838-845. PubMed PMID: 31941664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influenza vaccination reduces dementia in patients with chronic obstructive pulmonary disease: a nationwide cohort study. AU - Luo,Ching-Shan, AU - Chi,Ching-Chi, AU - Fang,Yu-Ann, AU - Liu,Ju-Chi, AU - Lee,Kang-Yun, Y1 - 2020/01/14/ PY - 2019/12/07/accepted PY - 2020/1/17/pubmed PY - 2020/1/17/medline PY - 2020/1/17/entrez KW - chronic obstructive pulmonary disease KW - dementia KW - dose effect KW - frequent exacerbation KW - influenza vaccination SP - 838 EP - 845 JF - Journal of investigative medicine : the official publication of the American Federation for Clinical Research JO - J. Investig. Med. VL - 68 IS - 4 N2 - This study aimed to explore the protective potential of influenza vaccination against occurrence of dementia in patients with chronic obstructive pulmonary disease (COPD), who are expected to be more vulnerable to influenza infection. This nationwide retrospective cohort study enrolled patients with COPD (aged ≥60 years) from 1 January 2001 to 31 December 2012 by using the Taiwan National Health Insurance Research Database. By applying time-dependent Cox proportional hazard model, we used multivariate analysis to calculate the adjusted HR (aHR) with 95% CI of dementia in relation to influenza vaccination among patients with COPD. Besides, patients were partitioned into four groups according to the vaccination number (unvaccinated, 1, 2-3 and ≥4 total vaccinations) to investigate the dose-response effect of vaccinations on the dementia incidence. This cohort study included 19 848 patients with COPD, and 45% of them received influenza vaccination. The aHR of dementia was 0.68 (95% CI: 0.62 to 0.74, p<0.001) comparing vaccinated patients with unvaccinated ones. Furthermore, there was a trend of dementia risk reduction with the vaccination number. For patients who received 2-3 vaccinations, the aHR was 0.81 (95% CI: 0.73 to 0.90), and for those received 4 vaccinations, the aHR was 0.44 (95% CI: 0.40 to 0.50), with p for trend <0.001. In conclusion, annual influenza vaccination can reduce the risk of dementia in patient with COPD in a dose-dependent manner. SN - 1708-8267 UR - https://www.unboundmedicine.com/medline/citation/31941664/Influenza_vaccination_reduces_dementia_in_patients_with_chronic_obstructive_pulmonary_disease:_a_nationwide_cohort_study_ L2 - http://jim.bmj.com/cgi/pmidlookup?view=long&amp;pmid=31941664 DB - PRIME DP - Unbound Medicine ER -
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