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Lessons of the month 3: Duodenal perforation after polystyrene sulfonate.
Clin Med (Lond). 2020 Jan; 20(1):107-109.CM

Abstract

Ion-exchange resins, sodium or calcium polystyrene sulfonate, are commonly used medications for management of hyperkalaemia. However, the drug can be associated with serious bowel injury. We report a case of a renal transplant recipient who developed duodenal ulcer perforation secondary to the use of calcium polystyrene sulfonate. Characteristic eosinophilic non-polarisable rhomboid shaped crystals were evident in the affected area of ulceration on histologic examination in addition to features of cytomegalovirus inclusions. We also hypothesised that gastroparesis secondary to autonomic dysfunction could have led to prolonged luminal contact time with polystyrene, further predisposing to bowel injury.

Authors+Show Affiliations

Prince of Wales Hospital, Hong Kong.Prince of Wales Hospital, Hong Kong.The Chinese University of Hong Kong, Hong Kong.Prince of Wales Hospital, Hong Kong.Prince of Wales Hospital, Hong Kong chow_kai_ming@alumni.cuhk.net.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31941743

Citation

Fung, Winston Ws, et al. "Lessons of the Month 3: Duodenal Perforation After Polystyrene Sulfonate." Clinical Medicine (London, England), vol. 20, no. 1, 2020, pp. 107-109.
Fung WW, Chi WK, Szeto CC, et al. Lessons of the month 3: Duodenal perforation after polystyrene sulfonate. Clin Med (Lond). 2020;20(1):107-109.
Fung, W. W., Chi, W. K., Szeto, C. C., Li, P. K., & Chow, K. M. (2020). Lessons of the month 3: Duodenal perforation after polystyrene sulfonate. Clinical Medicine (London, England), 20(1), 107-109. https://doi.org/10.7861/clinmed.2019-0327
Fung WW, et al. Lessons of the Month 3: Duodenal Perforation After Polystyrene Sulfonate. Clin Med (Lond). 2020;20(1):107-109. PubMed PMID: 31941743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lessons of the month 3: Duodenal perforation after polystyrene sulfonate. AU - Fung,Winston Ws, AU - Chi,Wai Kin, AU - Szeto,Cheuk Chun, AU - Li,Philip K-T, AU - Chow,Kai Ming, PY - 2020/1/17/entrez PY - 2020/1/17/pubmed PY - 2020/1/17/medline KW - Hyperkalaemia KW - cytomegalovirus KW - intestinal perforation KW - polystyrene KW - renal transplant SP - 107 EP - 109 JF - Clinical medicine (London, England) JO - Clin Med (Lond) VL - 20 IS - 1 N2 - Ion-exchange resins, sodium or calcium polystyrene sulfonate, are commonly used medications for management of hyperkalaemia. However, the drug can be associated with serious bowel injury. We report a case of a renal transplant recipient who developed duodenal ulcer perforation secondary to the use of calcium polystyrene sulfonate. Characteristic eosinophilic non-polarisable rhomboid shaped crystals were evident in the affected area of ulceration on histologic examination in addition to features of cytomegalovirus inclusions. We also hypothesised that gastroparesis secondary to autonomic dysfunction could have led to prolonged luminal contact time with polystyrene, further predisposing to bowel injury. SN - 1473-4893 UR - https://www.unboundmedicine.com/medline/citation/31941743/Lessons_of_the_month_3:_Duodenal_perforation_after_polystyrene_sulfonate L2 - https://www.rcpjournals.org/lookup/pmid/31941743 DB - PRIME DP - Unbound Medicine ER -
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