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Small fiber neuropathy in unexpected clinical settings: a review.

Abstract

Small fiber neuropathy (SFN) is being recognized with increasing frequency in neuromuscular practice due to improved diagnostic techniques. Although there are some common etiologies, up to one-third of cases are considered idiopathic. In recent years, several disorders have unexpectedly been reported in association with SFN, on clinical grounds and complementary investigations, including quantitative sensory testing, intraepidermal nerve fiber density and confocal corneal microscopy. Knowledge of these disorders is important in clinical practice as increased awareness enables prompt diagnosis of SFN in these settings and early optimal therapeutic management of affected patients. Furthermore, these new developments may lead to a better understanding of the pathophysiologic mechanisms underlying SFN in these different disorders as well as, in some cases, an expanded spectrum of affected organs and systems. This article reviews these reported associations, their possible pathophysiologic bases, and the potential resulting management implications. This article is protected by copyright. All rights reserved.

Authors+Show Affiliations

Regional Neuromuscular Service, University Hospitals Birmingham, Birmingham, U.K. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Regional Neuromuscular Service, University Hospitals Birmingham, Birmingham, U.K. Aston Medical School, Aston University, Birmingham, U.K.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31943276

Citation

Ghasemi, Majid, and Yusuf A. Rajabally. "Small Fiber Neuropathy in Unexpected Clinical Settings: a Review." Muscle & Nerve, 2020.
Ghasemi M, Rajabally YA. Small fiber neuropathy in unexpected clinical settings: a review. Muscle Nerve. 2020.
Ghasemi, M., & Rajabally, Y. A. (2020). Small fiber neuropathy in unexpected clinical settings: a review. Muscle & Nerve, doi:10.1002/mus.26808.
Ghasemi M, Rajabally YA. Small Fiber Neuropathy in Unexpected Clinical Settings: a Review. Muscle Nerve. 2020 Jan 14; PubMed PMID: 31943276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small fiber neuropathy in unexpected clinical settings: a review. AU - Ghasemi,Majid, AU - Rajabally,Yusuf A, Y1 - 2020/01/14/ PY - 2019/03/11/received PY - 2020/01/07/revised PY - 2020/01/11/accepted PY - 2020/1/17/entrez KW - Parkinson disease KW - REM sleep behavior disorder KW - amyotrophic lateral sclerosis KW - inflammatory neuropathy KW - obstructive sleep apnea syndrome KW - small fiber neuropathy KW - vaccination JF - Muscle & nerve JO - Muscle Nerve N2 - Small fiber neuropathy (SFN) is being recognized with increasing frequency in neuromuscular practice due to improved diagnostic techniques. Although there are some common etiologies, up to one-third of cases are considered idiopathic. In recent years, several disorders have unexpectedly been reported in association with SFN, on clinical grounds and complementary investigations, including quantitative sensory testing, intraepidermal nerve fiber density and confocal corneal microscopy. Knowledge of these disorders is important in clinical practice as increased awareness enables prompt diagnosis of SFN in these settings and early optimal therapeutic management of affected patients. Furthermore, these new developments may lead to a better understanding of the pathophysiologic mechanisms underlying SFN in these different disorders as well as, in some cases, an expanded spectrum of affected organs and systems. This article reviews these reported associations, their possible pathophysiologic bases, and the potential resulting management implications. This article is protected by copyright. All rights reserved. SN - 1097-4598 UR - https://www.unboundmedicine.com/medline/citation/31943276/Small_fiber_neuropathy_in_unexpected_clinical_settings:_a_review L2 - https://doi.org/10.1002/mus.26808 DB - PRIME DP - Unbound Medicine ER -