Human cytomegalovirus infection in Iranian glioma patients correlates with aging and tumor aggressiveness.J Med Virol 2020JM
Human cytomegalovirus (HCMV), as a ubiquitous and opportunistic virus, is a matter of consideration in broad-spectrum diseases, specifically in immunocompromised individuals. In recent decades, many studies that have evaluated the role of HCMV in inflammation and malignancies, especially in high grade gliomas(HGG), have reported inconsistent results. Thus, this study was conducted to analyze 97 primary gliomas for human CMV UL83 gene and protein through the Taqman real-time PCR and immunohistochemistry (IHC), respectively. The results were positive for UL83 gene and pp65 protein in 71% and 24% of samples, respectively. The frequency HCMV was significantly higher in glioblastomas than other glioma grades (p < 0.01 and < 0.05 for UL83 gene and protein, respectively). In addition, the association between the prevalence of HCMV and aging strengthened the virus reactivation hypothesis in gliomas. In conclusion, a high frequency of HCMV infection was found in gliomas that correlated with tumor aggressiveness and age. This study recommends a thorough investigation to determine HCMV infection in gliomas to improve the existing knowledge of its roles in glial tumors, its prognostic value, and the possible efficient antiviral target therapy. This article is protected by copyright. All rights reserved.