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Human cytomegalovirus infection in Iranian glioma patients correlates with aging and tumor aggressiveness.

Abstract

Human cytomegalovirus (HCMV), as a ubiquitous and opportunistic virus, is a matter of consideration in broad-spectrum diseases, specifically in immunocompromised individuals. In recent decades, many studies that have evaluated the role of HCMV in inflammation and malignancies, especially in high grade gliomas(HGG), have reported inconsistent results. Thus, this study was conducted to analyze 97 primary gliomas for human CMV UL83 gene and protein through the Taqman real-time PCR and immunohistochemistry (IHC), respectively. The results were positive for UL83 gene and pp65 protein in 71% and 24% of samples, respectively. The frequency HCMV was significantly higher in glioblastomas than other glioma grades (p < 0.01 and < 0.05 for UL83 gene and protein, respectively). In addition, the association between the prevalence of HCMV and aging strengthened the virus reactivation hypothesis in gliomas. In conclusion, a high frequency of HCMV infection was found in gliomas that correlated with tumor aggressiveness and age. This study recommends a thorough investigation to determine HCMV infection in gliomas to improve the existing knowledge of its roles in glial tumors, its prognostic value, and the possible efficient antiviral target therapy. This article is protected by copyright. All rights reserved.

Authors+Show Affiliations

Human Viral Vaccine Department, Razi Vaccine & Serum Research Institute, Agricultural Research, Education & Extension Organization (AREEO), Razi Vaccine and Serum Research Institute, Hessarak, Karaj, Alborz Province, Iran.Human Viral Vaccine Department, Razi Vaccine & Serum Research Institute, Agricultural Research, Education & Extension Organization (AREEO), Razi Vaccine and Serum Research Institute, Hessarak, Karaj, Alborz Province, Iran.Cellular and Molecular biology research center, health research institute, Babol University of Medical Sciences, Babol, Mazandaran, Province, Iran.Cancer Biology Research Center, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, End of Keshavarz Blvd., Tehran, Iran.Department of Virology, School of Public Health, Tehran University of Medical sciences.Department of Pathology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Tehran, Province, Iran.Cancer Biology Research Center, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, End of Keshavarz Blvd., Tehran, Iran. Cancer Research Center, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, End of Keshavarz Blvd., Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31944314

Citation

Maleki, Faezeh, et al. "Human Cytomegalovirus Infection in Iranian Glioma Patients Correlates With Aging and Tumor Aggressiveness." Journal of Medical Virology, 2020.
Maleki F, Sadigh ZA, Sadeghi F, et al. Human cytomegalovirus infection in Iranian glioma patients correlates with aging and tumor aggressiveness. J Med Virol. 2020.
Maleki, F., Sadigh, Z. A., Sadeghi, F., Muhammadnejad, A., Farahmand, M., Parvin, M., & Shirkoohi, R. (2020). Human cytomegalovirus infection in Iranian glioma patients correlates with aging and tumor aggressiveness. Journal of Medical Virology, doi:10.1002/jmv.25673.
Maleki F, et al. Human Cytomegalovirus Infection in Iranian Glioma Patients Correlates With Aging and Tumor Aggressiveness. J Med Virol. 2020 Jan 16; PubMed PMID: 31944314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human cytomegalovirus infection in Iranian glioma patients correlates with aging and tumor aggressiveness. AU - Maleki,Faezeh, AU - Sadigh,Zohreh-Azita, AU - Sadeghi,Farzin, AU - Muhammadnejad,Ahad, AU - Farahmand,Mohammad, AU - Parvin,Mahmoud, AU - Shirkoohi,Reza, Y1 - 2020/01/16/ PY - 2020/1/17/entrez KW - Glioblastoma Multiform KW - Glioma KW - Human Cytomegalovirus KW - UL83 KW - pp65 JF - Journal of medical virology JO - J. Med. Virol. N2 - Human cytomegalovirus (HCMV), as a ubiquitous and opportunistic virus, is a matter of consideration in broad-spectrum diseases, specifically in immunocompromised individuals. In recent decades, many studies that have evaluated the role of HCMV in inflammation and malignancies, especially in high grade gliomas(HGG), have reported inconsistent results. Thus, this study was conducted to analyze 97 primary gliomas for human CMV UL83 gene and protein through the Taqman real-time PCR and immunohistochemistry (IHC), respectively. The results were positive for UL83 gene and pp65 protein in 71% and 24% of samples, respectively. The frequency HCMV was significantly higher in glioblastomas than other glioma grades (p < 0.01 and < 0.05 for UL83 gene and protein, respectively). In addition, the association between the prevalence of HCMV and aging strengthened the virus reactivation hypothesis in gliomas. In conclusion, a high frequency of HCMV infection was found in gliomas that correlated with tumor aggressiveness and age. This study recommends a thorough investigation to determine HCMV infection in gliomas to improve the existing knowledge of its roles in glial tumors, its prognostic value, and the possible efficient antiviral target therapy. This article is protected by copyright. All rights reserved. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/31944314/Human_cytomegalovirus_infection_in_Iranian_glioma_patients_correlates_with_aging_and_tumor_aggressiveness L2 - https://doi.org/10.1002/jmv.25673 DB - PRIME DP - Unbound Medicine ER -