Tags

Type your tag names separated by a space and hit enter

Chemoradiotherapy-induced Cytodifferentiation in Bladder/Prostate Rhabdomyosarcoma with Genetic Downregulation of Myogenin and MyoD1 Gene Expression: A Case Study and Review of the Literature.
Urology 2020U

Abstract

Rhabdomyosarcoma is the most common sarcoma diagnosed in childhood and adolescence, arising from the bladder/prostate in only 5-10% of cases. Treatment-induced cytodifferention of tumor cells into mature rhabdomyoblasts has been reported following chemoradiation and is thought to suggest a more favorable outcome. We report a case of embryonal rhabdomyosarcoma of the bladder/prostate that exhibited extensive cytodifferentiation with downregulation of myogenin and MyoD1 gene expression in rhabdomyoblasts following treatment with chemoradiation therapy. The downregulation of myogenin and MyoD1 expression in rhabdomyoblasts following chemoradiation treatment has not previously been described in the literature and its significant remains uncertain.

Authors+Show Affiliations

Department of Urology, Cleveland Clinic Akron General, Akron, OH. Electronic address: agardh12@gmail.com.Pediatric & Adolescent Urology, Inc./Akron Children's Hospital, Akron, OH.Pediatric & Adolescent Urology, Inc./Akron Children's Hospital, Akron, OH.Pathology and Laboratory Medicine/Akron Children's Hospital, Akron, OH.Pediatric & Adolescent Urology, Inc./Akron Children's Hospital, Akron, OH.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31945380

Citation

Agard, H, et al. "Chemoradiotherapy-induced Cytodifferentiation in Bladder/Prostate Rhabdomyosarcoma With Genetic Downregulation of Myogenin and MyoD1 Gene Expression: a Case Study and Review of the Literature." Urology, 2020.
Agard H, Clark C, Massanyi E, et al. Chemoradiotherapy-induced Cytodifferentiation in Bladder/Prostate Rhabdomyosarcoma with Genetic Downregulation of Myogenin and MyoD1 Gene Expression: A Case Study and Review of the Literature. Urology. 2020.
Agard, H., Clark, C., Massanyi, E., Steele, M., & McMahon, D. (2020). Chemoradiotherapy-induced Cytodifferentiation in Bladder/Prostate Rhabdomyosarcoma with Genetic Downregulation of Myogenin and MyoD1 Gene Expression: A Case Study and Review of the Literature. Urology, doi:10.1016/j.urology.2019.11.050.
Agard H, et al. Chemoradiotherapy-induced Cytodifferentiation in Bladder/Prostate Rhabdomyosarcoma With Genetic Downregulation of Myogenin and MyoD1 Gene Expression: a Case Study and Review of the Literature. Urology. 2020 Jan 13; PubMed PMID: 31945380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemoradiotherapy-induced Cytodifferentiation in Bladder/Prostate Rhabdomyosarcoma with Genetic Downregulation of Myogenin and MyoD1 Gene Expression: A Case Study and Review of the Literature. AU - Agard,H, AU - Clark,C, AU - Massanyi,E, AU - Steele,M, AU - McMahon,D, Y1 - 2020/01/13/ PY - 2019/09/04/received PY - 2019/09/04/revised PY - 2019/11/21/accepted PY - 2020/1/17/entrez PY - 2020/1/17/pubmed PY - 2020/1/17/medline KW - bladder KW - cytodifferentiation KW - myogenin KW - pediatric KW - prostate KW - rhabdomyosarcoma JF - Urology JO - Urology N2 - Rhabdomyosarcoma is the most common sarcoma diagnosed in childhood and adolescence, arising from the bladder/prostate in only 5-10% of cases. Treatment-induced cytodifferention of tumor cells into mature rhabdomyoblasts has been reported following chemoradiation and is thought to suggest a more favorable outcome. We report a case of embryonal rhabdomyosarcoma of the bladder/prostate that exhibited extensive cytodifferentiation with downregulation of myogenin and MyoD1 gene expression in rhabdomyoblasts following treatment with chemoradiation therapy. The downregulation of myogenin and MyoD1 expression in rhabdomyoblasts following chemoradiation treatment has not previously been described in the literature and its significant remains uncertain. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/31945380/Chemoradiotherapy-induced_Cytodifferentiation_in_Bladder/Prostate_Rhabdomyosarcoma_with_Genetic_Downregulation_of_Myogenin_and_MyoD1_Gene_Expression:_A_Case_Study_and_Review_of_the_Literature L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(20)30013-3 DB - PRIME DP - Unbound Medicine ER -