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Preparation, characterization and antitumor activity of a cationic starch-derivative membrane embedded with a β-cyclodextrin/curcumin inclusion complex.
Int J Biol Macromol 2020; 148:140-152IJ

Abstract

A membrane of cationic starch-derivative/poly(vinyl alcohol) was prepared and utilized as a support to immobilize a β-cyclodextrin/curcumin inclusion complex. The resulting material (denote as β-CD/CUR-MBN) was characterized in detail by different techniques. In vitro experiments revealed that β-CD/CUR-MBN enables the controlling of the curcumin release process, which is guided by the relaxation of the polymer matrix. Moreover, cytotoxic assays were performed to investigate the effect of β-CD/CUR-MBN on two cancer cell lines (melanoma and glioblastoma). The results showed that the polymeric membrane exerts higher cytotoxicity against these cells than free curcumin. Also, β-CD/CUR-MBN exerted a prolonged cytotoxic effect (up to 96 h), even using a low concentration (50 μg mL-1), indicating that the curcumin in the polymeric membrane showed increased bioavailability under the tested condition. β-CD/CUR-MBN was non-cytotoxic against normal cells suggesting a specific action of this material against target cancer cells. The results reported here allow ranks β-CD/CUR-MBN as a promising biomaterial to act as a local drug delivery system to treat cancer.

Authors+Show Affiliations

Laboratório de Tecnologia e Desenvolvimento de Compósitos e Materiais Poliméricos (LaCoPol), Universidade Federal de Pelotas (UFPel), Campus Capão do Leão s/n, 96010-900 Pelotas, RS, Brazil.Laboratório de Tecnologia e Desenvolvimento de Compósitos e Materiais Poliméricos (LaCoPol), Universidade Federal de Pelotas (UFPel), Campus Capão do Leão s/n, 96010-900 Pelotas, RS, Brazil.Laboratório de Neuroquímica, Inflamação e Câncer (Neurocan), Universidade Federal de Pelotas (UFPel), Campus Capão do Leão s/n, 96010-900 Pelotas, RS, Brazil.Laboratório de Neuroquímica, Inflamação e Câncer (Neurocan), Universidade Federal de Pelotas (UFPel), Campus Capão do Leão s/n, 96010-900 Pelotas, RS, Brazil.Laboratório de Neuroquímica, Inflamação e Câncer (Neurocan), Universidade Federal de Pelotas (UFPel), Campus Capão do Leão s/n, 96010-900 Pelotas, RS, Brazil.Laboratório de Neuroquímica, Inflamação e Câncer (Neurocan), Universidade Federal de Pelotas (UFPel), Campus Capão do Leão s/n, 96010-900 Pelotas, RS, Brazil.Laboratório de Tecnologia e Desenvolvimento de Compósitos e Materiais Poliméricos (LaCoPol), Universidade Federal de Pelotas (UFPel), Campus Capão do Leão s/n, 96010-900 Pelotas, RS, Brazil. Electronic address: andre.fajardo@pq.cnpq.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31945443

Citation

Gularte, Matheus S., et al. "Preparation, Characterization and Antitumor Activity of a Cationic Starch-derivative Membrane Embedded With a Β-cyclodextrin/curcumin Inclusion Complex." International Journal of Biological Macromolecules, vol. 148, 2020, pp. 140-152.
Gularte MS, Quadrado RFN, Pedra NS, et al. Preparation, characterization and antitumor activity of a cationic starch-derivative membrane embedded with a β-cyclodextrin/curcumin inclusion complex. Int J Biol Macromol. 2020;148:140-152.
Gularte, M. S., Quadrado, R. F. N., Pedra, N. S., Soares, M. S. P., Bona, N. P., Spanevello, R. M., & Fajardo, A. R. (2020). Preparation, characterization and antitumor activity of a cationic starch-derivative membrane embedded with a β-cyclodextrin/curcumin inclusion complex. International Journal of Biological Macromolecules, 148, pp. 140-152. doi:10.1016/j.ijbiomac.2020.01.104.
Gularte MS, et al. Preparation, Characterization and Antitumor Activity of a Cationic Starch-derivative Membrane Embedded With a Β-cyclodextrin/curcumin Inclusion Complex. Int J Biol Macromol. 2020 Jan 13;148:140-152. PubMed PMID: 31945443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation, characterization and antitumor activity of a cationic starch-derivative membrane embedded with a β-cyclodextrin/curcumin inclusion complex. AU - Gularte,Matheus S, AU - Quadrado,Rafael F N, AU - Pedra,Nathalia S, AU - Soares,Mayara S P, AU - Bona,Natália P, AU - Spanevello,Roselia M, AU - Fajardo,André R, Y1 - 2020/01/13/ PY - 2019/10/18/received PY - 2019/11/22/revised PY - 2020/01/09/accepted PY - 2020/1/17/pubmed PY - 2020/1/17/medline PY - 2020/1/17/entrez KW - Antitumor activity KW - Cationic starch KW - Curcumin KW - Glioblastoma KW - Inclusion complex KW - Melanoma SP - 140 EP - 152 JF - International journal of biological macromolecules JO - Int. J. Biol. Macromol. VL - 148 N2 - A membrane of cationic starch-derivative/poly(vinyl alcohol) was prepared and utilized as a support to immobilize a β-cyclodextrin/curcumin inclusion complex. The resulting material (denote as β-CD/CUR-MBN) was characterized in detail by different techniques. In vitro experiments revealed that β-CD/CUR-MBN enables the controlling of the curcumin release process, which is guided by the relaxation of the polymer matrix. Moreover, cytotoxic assays were performed to investigate the effect of β-CD/CUR-MBN on two cancer cell lines (melanoma and glioblastoma). The results showed that the polymeric membrane exerts higher cytotoxicity against these cells than free curcumin. Also, β-CD/CUR-MBN exerted a prolonged cytotoxic effect (up to 96 h), even using a low concentration (50 μg mL-1), indicating that the curcumin in the polymeric membrane showed increased bioavailability under the tested condition. β-CD/CUR-MBN was non-cytotoxic against normal cells suggesting a specific action of this material against target cancer cells. The results reported here allow ranks β-CD/CUR-MBN as a promising biomaterial to act as a local drug delivery system to treat cancer. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/31945443/Preparation,_characterization_and_antitumor_activity_of_a_cationic_starch-derivative_membrane_embedded_with_a_β-cyclodextrin/curcumin_inclusion_complex L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(19)38470-3 DB - PRIME DP - Unbound Medicine ER -