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TRPC Channels in the SOCE Scenario.
Cells. 2020 01 05; 9(1)C

Abstract

Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well known that these channels are activated by stimuli that induce PIP2 hydrolysis. The canonical TRP (TRPC) channels have long been suggested to be constituents of the store-operated Ca2+ (SOC) channels; however, none of the TRPC channels generate Ca2+ currents that resemble ICRAC. STIM1 and Orai1 have been identified as the components of the Ca2+ release-activated Ca2+ (CRAC) channels and there is a body of evidence supporting that STIM1 is able to gate Orai1 and TRPC1 in order to mediate non-selective cation currents named ISOC. STIM1 has been found to interact to and activate Orai1 and TRPC1 by different mechanisms and the involvement of TRPC1 in store-operated Ca2+ entry requires both STIM1 and Orai1. In addition to the participation of TRPC1 in the ISOC currents, TRPC1 and other TRPC proteins might play a relevant role modulating Orai1 channel function. This review summarizes the functional role of TRPC channels in the STIM1-Orai1 scenario.

Authors+Show Affiliations

Department of Physiology (Cell Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003-Caceres, Spain.Department of Physiology (Cell Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003-Caceres, Spain.Department of Physiology (Cell Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003-Caceres, Spain.Department of Physiology (Cell Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003-Caceres, Spain.Department of Medical Physiology and Biophysics, Institute of Biomedicine of Sevilla, 41013 Sevilla, Spain.Department of Physiology (Cell Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003-Caceres, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

31948094

Citation

Lopez, Jose J., et al. "TRPC Channels in the SOCE Scenario." Cells, vol. 9, no. 1, 2020.
Lopez JJ, Jardin I, Sanchez-Collado J, et al. TRPC Channels in the SOCE Scenario. Cells. 2020;9(1).
Lopez, J. J., Jardin, I., Sanchez-Collado, J., Salido, G. M., Smani, T., & Rosado, J. A. (2020). TRPC Channels in the SOCE Scenario. Cells, 9(1). https://doi.org/10.3390/cells9010126
Lopez JJ, et al. TRPC Channels in the SOCE Scenario. Cells. 2020 01 5;9(1) PubMed PMID: 31948094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TRPC Channels in the SOCE Scenario. AU - Lopez,Jose J, AU - Jardin,Isaac, AU - Sanchez-Collado,Jose, AU - Salido,Ginés M, AU - Smani,Tarik, AU - Rosado,Juan A, Y1 - 2020/01/05/ PY - 2019/12/11/received PY - 2019/12/29/revised PY - 2019/12/31/accepted PY - 2020/1/18/entrez PY - 2020/1/18/pubmed PY - 2021/1/16/medline KW - Orai1 KW - STIM1 KW - TRPC1 KW - calcium influx KW - store-operated Ca2+ entry (SOCE) JF - Cells JO - Cells VL - 9 IS - 1 N2 - Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well known that these channels are activated by stimuli that induce PIP2 hydrolysis. The canonical TRP (TRPC) channels have long been suggested to be constituents of the store-operated Ca2+ (SOC) channels; however, none of the TRPC channels generate Ca2+ currents that resemble ICRAC. STIM1 and Orai1 have been identified as the components of the Ca2+ release-activated Ca2+ (CRAC) channels and there is a body of evidence supporting that STIM1 is able to gate Orai1 and TRPC1 in order to mediate non-selective cation currents named ISOC. STIM1 has been found to interact to and activate Orai1 and TRPC1 by different mechanisms and the involvement of TRPC1 in store-operated Ca2+ entry requires both STIM1 and Orai1. In addition to the participation of TRPC1 in the ISOC currents, TRPC1 and other TRPC proteins might play a relevant role modulating Orai1 channel function. This review summarizes the functional role of TRPC channels in the STIM1-Orai1 scenario. SN - 2073-4409 UR - https://www.unboundmedicine.com/medline/citation/31948094/TRPC_Channels_in_the_SOCE_Scenario_ L2 - https://www.mdpi.com/resolver?pii=cells9010126 DB - PRIME DP - Unbound Medicine ER -