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Glomus Tumor of Sella Turcica With Synaptophysin Expression Mimicking Pituitary Adenoma.
Int J Surg Pathol. 2020 Jun; 28(4):401-405.IJ

Abstract

Glomus tumor can rarely arise in the central nervous system as a sella turcica mass. In this article, we report a case of sellar glomus tumor in a female patient who presented at the age of 8 years with visual impairment. The tumor recurred at 4 years and 26 years after initial excision and gamma knife therapy. Histologic examination showed a monotonous population of oval cells accompanied by delicate blood vessels, features mimicking pituitary adenoma. The tumor showed histologic progression at the second recurrence. Synaptophysin staining was positive, but chromogranin and CD56 were negative. The tumor cells were negative for epithelial markers but expressed actin and SMA. Awareness of the rare occurrence of glomus tumor at this region, careful analysis of morphology, and appropriate immunohistochemical workup are essential to solve this diagnostic challenge. The clinicopathologic features of all previously reported cases are reviewed.

Authors+Show Affiliations

Queen Elizabeth Hospital, Hong Kong, SAR China.St Teresa's Hospital, Hong Kong, SAR China.St Teresa's Hospital, Hong Kong, SAR China.Queen Elizabeth Hospital, Hong Kong, SAR China.Queen Elizabeth Hospital, Hong Kong, SAR China.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

31948309

Citation

Tsang, Jason C H., et al. "Glomus Tumor of Sella Turcica With Synaptophysin Expression Mimicking Pituitary Adenoma." International Journal of Surgical Pathology, vol. 28, no. 4, 2020, pp. 401-405.
Tsang JCH, Ng CS, Fung CF, et al. Glomus Tumor of Sella Turcica With Synaptophysin Expression Mimicking Pituitary Adenoma. Int J Surg Pathol. 2020;28(4):401-405.
Tsang, J. C. H., Ng, C. S., Fung, C. F., Chan, J. K. C., & Cheuk, W. (2020). Glomus Tumor of Sella Turcica With Synaptophysin Expression Mimicking Pituitary Adenoma. International Journal of Surgical Pathology, 28(4), 401-405. https://doi.org/10.1177/1066896919900550
Tsang JCH, et al. Glomus Tumor of Sella Turcica With Synaptophysin Expression Mimicking Pituitary Adenoma. Int J Surg Pathol. 2020;28(4):401-405. PubMed PMID: 31948309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glomus Tumor of Sella Turcica With Synaptophysin Expression Mimicking Pituitary Adenoma. AU - Tsang,Jason C H, AU - Ng,C S, AU - Fung,C F, AU - Chan,John K C, AU - Cheuk,Wah, Y1 - 2020/01/16/ PY - 2020/1/18/pubmed PY - 2021/1/20/medline PY - 2020/1/18/entrez KW - glomus tumor KW - glomus tumor of uncertain malignant potential KW - sella turcica SP - 401 EP - 405 JF - International journal of surgical pathology JO - Int J Surg Pathol VL - 28 IS - 4 N2 - Glomus tumor can rarely arise in the central nervous system as a sella turcica mass. In this article, we report a case of sellar glomus tumor in a female patient who presented at the age of 8 years with visual impairment. The tumor recurred at 4 years and 26 years after initial excision and gamma knife therapy. Histologic examination showed a monotonous population of oval cells accompanied by delicate blood vessels, features mimicking pituitary adenoma. The tumor showed histologic progression at the second recurrence. Synaptophysin staining was positive, but chromogranin and CD56 were negative. The tumor cells were negative for epithelial markers but expressed actin and SMA. Awareness of the rare occurrence of glomus tumor at this region, careful analysis of morphology, and appropriate immunohistochemical workup are essential to solve this diagnostic challenge. The clinicopathologic features of all previously reported cases are reviewed. SN - 1940-2465 UR - https://www.unboundmedicine.com/medline/citation/31948309/Glomus_Tumor_of_Sella_Turcica_With_Synaptophysin_Expression_Mimicking_Pituitary_Adenoma_ DB - PRIME DP - Unbound Medicine ER -