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The Effect of Oral Probiotic on the Interleukin-10 Serum Levels of Acne Vulgaris.
Open Access Maced J Med Sci. 2019 Oct 15; 7(19):3249-3252.OA

Abstract

BACKGROUND

Acne vulgaris is a chronic inflammatory skin disorder that commonly found in pilosebaceous units which can have an impact on the patient's psychological burden. The relationship between dermatology and mental health is increasingly understood by the evidence shows that functional integrity and microbes in the gastrointestinal tract may play a role in mediating skin inflammation and emotional behaviour. The gut-brain-skin theory was first described in 1930 by Stokes and Pillsbury, became the basis of many current studies that look for clinical implications of the relationship between the gastrointestinal tract, brain and skin in acne vulgaris. Probiotics are live microorganisms which can provide a healthy effect to the hosts when consumed in adequate amounts.

AIM

To determine the effect of oral probiotic on the interleukin-10 serum levels in acne vulgaris and also to determine the side effect of oral probiotic on acne vulgaris.

METHODS

This is a pre-experimental clinical study with a pretest-posttest design involving 33 subjects with acne vulgaris. The subjects in this study were measured for IL-10 serum levels before and after oral probiotic was given for 30 days. This research has been approved by the Health Research Ethics Commission of the Faculty of Medicine, Universitas Sumatera Utara.

RESULTS

This study found an increase in serum IL-10 levels after oral probiotic in acne vulgaris. The value of serum IL-10 levels before oral probiotic administration was 5.27 ± 1.49 pg/ml, while the value of serum IL-10 levels after oral probiotic administration was 6.19 ± 1.68 pg/ml) with p values obtained through Wilcoxon test was 0,0001 (p < 0.05). The side effect of oral probiotic found in this study is bloating that was found in 2 subjects within the first week using oral probiotic.

CONCLUSION

Oral probiotic trigger elevated IL-10 serum levels of acne vulgaris. This study supports previous studies that suggested oral probiotic can be considered as adjuvant acne vulgaris therapy and its side effect is quite safe and tolerable.

Authors+Show Affiliations

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Universitas Sumatera Utara Hospital, Medan, Indonesia.Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Universitas Sumatera Utara Hospital, Medan, Indonesia.Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Universitas Sumatera Utara Hospital, Medan, Indonesia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31949525

Citation

Rahmayani, Tissan, et al. "The Effect of Oral Probiotic On the Interleukin-10 Serum Levels of Acne Vulgaris." Open Access Macedonian Journal of Medical Sciences, vol. 7, no. 19, 2019, pp. 3249-3252.
Rahmayani T, Putra IB, Jusuf NK. The Effect of Oral Probiotic on the Interleukin-10 Serum Levels of Acne Vulgaris. Open Access Maced J Med Sci. 2019;7(19):3249-3252.
Rahmayani, T., Putra, I. B., & Jusuf, N. K. (2019). The Effect of Oral Probiotic on the Interleukin-10 Serum Levels of Acne Vulgaris. Open Access Macedonian Journal of Medical Sciences, 7(19), 3249-3252. https://doi.org/10.3889/oamjms.2019.718
Rahmayani T, Putra IB, Jusuf NK. The Effect of Oral Probiotic On the Interleukin-10 Serum Levels of Acne Vulgaris. Open Access Maced J Med Sci. 2019 Oct 15;7(19):3249-3252. PubMed PMID: 31949525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effect of Oral Probiotic on the Interleukin-10 Serum Levels of Acne Vulgaris. AU - Rahmayani,Tissan, AU - Putra,Imam Budi, AU - Jusuf,Nelva Karmilla, Y1 - 2019/10/10/ PY - 2019/05/26/received PY - 2019/09/21/revised PY - 2019/09/22/accepted PY - 2020/1/18/entrez PY - 2020/1/18/pubmed PY - 2020/1/18/medline KW - Acne vulgaris KW - Oral probiotic KW - Serum IL-10 levels SP - 3249 EP - 3252 JF - Open access Macedonian journal of medical sciences JO - Open Access Maced J Med Sci VL - 7 IS - 19 N2 - BACKGROUND: Acne vulgaris is a chronic inflammatory skin disorder that commonly found in pilosebaceous units which can have an impact on the patient's psychological burden. The relationship between dermatology and mental health is increasingly understood by the evidence shows that functional integrity and microbes in the gastrointestinal tract may play a role in mediating skin inflammation and emotional behaviour. The gut-brain-skin theory was first described in 1930 by Stokes and Pillsbury, became the basis of many current studies that look for clinical implications of the relationship between the gastrointestinal tract, brain and skin in acne vulgaris. Probiotics are live microorganisms which can provide a healthy effect to the hosts when consumed in adequate amounts. AIM: To determine the effect of oral probiotic on the interleukin-10 serum levels in acne vulgaris and also to determine the side effect of oral probiotic on acne vulgaris. METHODS: This is a pre-experimental clinical study with a pretest-posttest design involving 33 subjects with acne vulgaris. The subjects in this study were measured for IL-10 serum levels before and after oral probiotic was given for 30 days. This research has been approved by the Health Research Ethics Commission of the Faculty of Medicine, Universitas Sumatera Utara. RESULTS: This study found an increase in serum IL-10 levels after oral probiotic in acne vulgaris. The value of serum IL-10 levels before oral probiotic administration was 5.27 ± 1.49 pg/ml, while the value of serum IL-10 levels after oral probiotic administration was 6.19 ± 1.68 pg/ml) with p values obtained through Wilcoxon test was 0,0001 (p < 0.05). The side effect of oral probiotic found in this study is bloating that was found in 2 subjects within the first week using oral probiotic. CONCLUSION: Oral probiotic trigger elevated IL-10 serum levels of acne vulgaris. This study supports previous studies that suggested oral probiotic can be considered as adjuvant acne vulgaris therapy and its side effect is quite safe and tolerable. SN - 1857-9655 UR - https://www.unboundmedicine.com/medline/citation/31949525/The_Effect_of_Oral_Probiotic_on_the_Interleukin_10_Serum_Levels_of_Acne_Vulgaris_ L2 - https://doi.org/10.3889/oamjms.2019.718 DB - PRIME DP - Unbound Medicine ER -
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