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A Case Report of Extensive Cerebral Venous Sinus Thrombosis as a Presenting Sign of Relapsing Nephrotic Syndrome.
Case Rep Neurol Med. 2019; 2019:6840240.CR

Abstract

Nephrotic syndrome is defined by three characteristic features including proteinuria of >3 g in 24 hours, hypoalbuminemia of less than 3 g/dL, and peripheral edema. Multiple nephropathies can result in nephrotic syndrome. Most commonly, minimal change disease is seen in children under the age of 10, while adults are more commonly found to have membranous nephropathy. Hypercoagulability and thrombotic sequela can be seen in nephrotic syndrome, regardless of underlying etiology, and thrombosis is most commonly seen in deep veins of the lower extremities and renal veins. Our case identifies an adult with previously diagnosed and treated for minimal change disease who presented with weight gain, peripheral edema, foamy urine, headache but no neurologic deficits. The patient was found to have near to complete occlusion of the entire superior sagittal sinus, near complete occlusion of the left transverse and sigmoid sinuses, and nonocclusive thrombus in the right sigmoid sinus. She was treated with heparin and IV steroids then transitioned to warfarin and PO steroids, respectively, with resolution of symptoms. This case report emphasizes on the importance of recognizing CVST as a potential complication of nephrotic syndrome at both initial presentation and relapse.

Authors+Show Affiliations

University of South Florida, Department of Neurology, Tampa, FL, USA.University of South Florida, Department of Neurology, Tampa, FL, USA.University of South Florida, Department of Neurology, Tampa, FL, USA.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31949961

Citation

Lee, Janet K., et al. "A Case Report of Extensive Cerebral Venous Sinus Thrombosis as a Presenting Sign of Relapsing Nephrotic Syndrome." Case Reports in Neurological Medicine, vol. 2019, 2019, p. 6840240.
Lee JK, Murray K, Renati S. A Case Report of Extensive Cerebral Venous Sinus Thrombosis as a Presenting Sign of Relapsing Nephrotic Syndrome. Case Rep Neurol Med. 2019;2019:6840240.
Lee, J. K., Murray, K., & Renati, S. (2019). A Case Report of Extensive Cerebral Venous Sinus Thrombosis as a Presenting Sign of Relapsing Nephrotic Syndrome. Case Reports in Neurological Medicine, 2019, 6840240. https://doi.org/10.1155/2019/6840240
Lee JK, Murray K, Renati S. A Case Report of Extensive Cerebral Venous Sinus Thrombosis as a Presenting Sign of Relapsing Nephrotic Syndrome. Case Rep Neurol Med. 2019;2019:6840240. PubMed PMID: 31949961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Case Report of Extensive Cerebral Venous Sinus Thrombosis as a Presenting Sign of Relapsing Nephrotic Syndrome. AU - Lee,Janet K, AU - Murray,Kathleen, AU - Renati,Swetha, Y1 - 2019/12/27/ PY - 2019/08/19/received PY - 2019/11/11/revised PY - 2019/11/22/accepted PY - 2020/1/18/entrez PY - 2020/1/18/pubmed PY - 2020/1/18/medline SP - 6840240 EP - 6840240 JF - Case reports in neurological medicine JO - Case Rep Neurol Med VL - 2019 N2 - Nephrotic syndrome is defined by three characteristic features including proteinuria of >3 g in 24 hours, hypoalbuminemia of less than 3 g/dL, and peripheral edema. Multiple nephropathies can result in nephrotic syndrome. Most commonly, minimal change disease is seen in children under the age of 10, while adults are more commonly found to have membranous nephropathy. Hypercoagulability and thrombotic sequela can be seen in nephrotic syndrome, regardless of underlying etiology, and thrombosis is most commonly seen in deep veins of the lower extremities and renal veins. Our case identifies an adult with previously diagnosed and treated for minimal change disease who presented with weight gain, peripheral edema, foamy urine, headache but no neurologic deficits. The patient was found to have near to complete occlusion of the entire superior sagittal sinus, near complete occlusion of the left transverse and sigmoid sinuses, and nonocclusive thrombus in the right sigmoid sinus. She was treated with heparin and IV steroids then transitioned to warfarin and PO steroids, respectively, with resolution of symptoms. This case report emphasizes on the importance of recognizing CVST as a potential complication of nephrotic syndrome at both initial presentation and relapse. SN - 2090-6668 UR - https://www.unboundmedicine.com/medline/citation/31949961/A_Case_Report_of_Extensive_Cerebral_Venous_Sinus_Thrombosis_as_a_Presenting_Sign_of_Relapsing_Nephrotic_Syndrome L2 - https://dx.doi.org/10.1155/2019/6840240 DB - PRIME DP - Unbound Medicine ER -
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