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Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae co-infections among patients with newly diagnosed syphilis: a single-centre, cross-sectional study.
Cent Eur J Public Health. 2019 12; 27(4):285-291.CE

Abstract

OBJECTIVES

The aim of the study was to determine the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae co-infections among patients with newly diagnosed syphilis.

METHODS

In patients with any stage of newly diagnosed syphilis swabs were performed from urethra, rectum, pharynx and cervix according to the gender and type of sexual intercourse. From these smears standard validated nucleic acid amplification tests (NAATs) for Chlamydia trachomatis and Neisseria gonorrhoeae infections were done.

RESULTS

From 548 (488 men, 60 women) screened patients co-infection was detected in 15.9% of the cases. The majority of the co-infections (86.2%) were asymptomatic. The overall prevalence of chlamydial infection was 11.1% and 8.8% for gonococcal infections. In men who have sex with men (MSM) the prevalence of co-infections was significantly higher (20.0%) than in heterosexual men and women (4.2%) (p < 0.001). In MSM patients the presence of co-infection was significantly associated with HIV infection (p < 0.001). Among MSM 9.6% of the tests detected infection in anorectal site, while prevalence in urethral (2.8%) and pharyngeal (2.4%) localization was significantly lower. In heterosexual patients prevalence was less than 2.0% in all anatomic sites.

CONCLUSIONS

The implementation of screening tests in case of sexually transmitted infections in patients with newly diagnosed syphilis is an important part in the management of this disease. These results suggest that screening of asymptomatic heterosexual patients leads to detection of minimum co-infections, but in MSM (especially HIV positive) should always be performed at least in anorectal site, where asymptomatic co-infections are common.

Authors+Show Affiliations

Department of Dermatovenerology, Second Faculty of Medicine, Charles University, Na Bulovce Hospital, Prague, Czech Republic.Department of Dermatovenerology, Second Faculty of Medicine, Charles University, Na Bulovce Hospital, Prague, Czech Republic.Department of Dermatovenerology, Second Faculty of Medicine, Charles University, Na Bulovce Hospital, Prague, Czech Republic.Department of Dermatovenerology, Second Faculty of Medicine, Charles University, Na Bulovce Hospital, Prague, Czech Republic.Department of Microbiology, Na Bulovce Hospital, Prague, Czech Republic.Department of Microbiology, Na Bulovce Hospital, Prague, Czech Republic.Department of Infectious Diseases, Third Faculty of Medicine, Charles University, Na Bulovce Hospital, Prague, Czech Republic.Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University, Na Bulovce Hospital, Prague, Czech Republic.Department of Infectious Diseases, Second Faculty of Medicine, Charles University, Na Bulovce Hospital, Prague, Czech Republic.National Reference Laboratory for Diagnostics of Syphilis, National Institute of Public Health, Prague, Czech Republic.Department of Dermatovenerology, Second Faculty of Medicine, Charles University, Na Bulovce Hospital, Prague, Czech Republic.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31951687

Citation

Rob, Filip, et al. "Prevalence of Chlamydia Trachomatis and Neisseria Gonorrhoeae Co-infections Among Patients With Newly Diagnosed Syphilis: a Single-centre, Cross-sectional Study." Central European Journal of Public Health, vol. 27, no. 4, 2019, pp. 285-291.
Rob F, Jůzlová K, Kružicová Z, et al. Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae co-infections among patients with newly diagnosed syphilis: a single-centre, cross-sectional study. Cent Eur J Public Health. 2019;27(4):285-291.
Rob, F., Jůzlová, K., Kružicová, Z., Vaňousová, D., Lásiková, Š., Sýkorová, B., Machala, L., Rozsypal, H., Veselý, D., Zákoucká, H., & Hercogová, J. (2019). Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae co-infections among patients with newly diagnosed syphilis: a single-centre, cross-sectional study. Central European Journal of Public Health, 27(4), 285-291. https://doi.org/10.21101/cejph.a5142
Rob F, et al. Prevalence of Chlamydia Trachomatis and Neisseria Gonorrhoeae Co-infections Among Patients With Newly Diagnosed Syphilis: a Single-centre, Cross-sectional Study. Cent Eur J Public Health. 2019;27(4):285-291. PubMed PMID: 31951687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae co-infections among patients with newly diagnosed syphilis: a single-centre, cross-sectional study. AU - Rob,Filip, AU - Jůzlová,Kateřina, AU - Kružicová,Zuzana, AU - Vaňousová,Daniela, AU - Lásiková,Šárka, AU - Sýkorová,Blanka, AU - Machala,Ladislav, AU - Rozsypal,Hanuš, AU - Veselý,Dan, AU - Zákoucká,Hana, AU - Hercogová,Jana, PY - 2017/06/02/received PY - 2019/08/21/accepted PY - 2019/08/21/revised PY - 2020/1/18/entrez PY - 2020/1/18/pubmed PY - 2020/1/24/medline KW - MSM KW - chlamydia KW - gonorrhea KW - screening KW - syphilis SP - 285 EP - 291 JF - Central European journal of public health JO - Cent Eur J Public Health VL - 27 IS - 4 N2 - OBJECTIVES: The aim of the study was to determine the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae co-infections among patients with newly diagnosed syphilis. METHODS: In patients with any stage of newly diagnosed syphilis swabs were performed from urethra, rectum, pharynx and cervix according to the gender and type of sexual intercourse. From these smears standard validated nucleic acid amplification tests (NAATs) for Chlamydia trachomatis and Neisseria gonorrhoeae infections were done. RESULTS: From 548 (488 men, 60 women) screened patients co-infection was detected in 15.9% of the cases. The majority of the co-infections (86.2%) were asymptomatic. The overall prevalence of chlamydial infection was 11.1% and 8.8% for gonococcal infections. In men who have sex with men (MSM) the prevalence of co-infections was significantly higher (20.0%) than in heterosexual men and women (4.2%) (p < 0.001). In MSM patients the presence of co-infection was significantly associated with HIV infection (p < 0.001). Among MSM 9.6% of the tests detected infection in anorectal site, while prevalence in urethral (2.8%) and pharyngeal (2.4%) localization was significantly lower. In heterosexual patients prevalence was less than 2.0% in all anatomic sites. CONCLUSIONS: The implementation of screening tests in case of sexually transmitted infections in patients with newly diagnosed syphilis is an important part in the management of this disease. These results suggest that screening of asymptomatic heterosexual patients leads to detection of minimum co-infections, but in MSM (especially HIV positive) should always be performed at least in anorectal site, where asymptomatic co-infections are common. SN - 1210-7778 UR - https://www.unboundmedicine.com/medline/citation/31951687/Prevalence_of_Chlamydia_trachomatis_and_Neisseria_gonorrhoeae_co_infections_among_patients_with_newly_diagnosed_syphilis:_a_single_centre_cross_sectional_study_ L2 - https://doi.org/10.21101/cejph.a5142 DB - PRIME DP - Unbound Medicine ER -