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Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans.
Molecules. 2020 Jan 15; 25(2)M

Abstract

Orange, with various bioactive phytochemicals, exerts various beneficial health effects, including anti-cancer, antioxidant, and anti-inflammatory properties. However, its anti-aging effects remain unclear. In this study, the Caenorhabditis elegans (C. elegans) model was used to evaluate the effects of orange extracts on lifespan and stress resistance. The results indicated that orange extracts dose-dependently increased the mean lifespan of C. elegans by 10.5%, 18.0%, and 26.2% at the concentrations of 100, 200, and 400 mg/mL, respectively. Meanwhile, orange extracts promoted the healthspan by improving motility, and decreasing the accumulation of age pigment and intracellular reactive oxygen species (ROS) levels without damaging fertility. The survival rates of orange extract-fed worms were obviously higher than those of untreated worms against thermal and ultraviolet-B (UV-B) stress. Moreover, the activities of superoxide dismutase (SOD) and catalase (CAT) were significantly enhanced while malondialdehyde (MDA) contents were diminished. Further investigation revealed that worms supplemented with orange extracts resulted in upregulated levels of genes, including daf-16, sod-3, gst-4, sek-1, and skn-1, and the downregulation of age-1 expression. These findings revealed that orange extracts have potential anti-aging effects through extending the lifespan, enhancing stress resistance, and promoting the healthspan.

Authors+Show Affiliations

Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China. Ministry of Education Engineering Research Centre of Starch & Protein Processing, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China.Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853, USA.Ministry of Education Engineering Research Centre of Starch & Protein Processing, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China.Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China. Guangdong ERA Food & Life Health Research Institute, Guangzhou 510670, China.Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31952185

Citation

Wang, Jing, et al. "Effects of Orange Extracts On Longevity, Healthspan, and Stress Resistance in Caenorhabditis Elegans." Molecules (Basel, Switzerland), vol. 25, no. 2, 2020.
Wang J, Deng N, Wang H, et al. Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans. Molecules. 2020;25(2).
Wang, J., Deng, N., Wang, H., Li, T., Chen, L., Zheng, B., & Liu, R. H. (2020). Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans. Molecules (Basel, Switzerland), 25(2). https://doi.org/10.3390/molecules25020351
Wang J, et al. Effects of Orange Extracts On Longevity, Healthspan, and Stress Resistance in Caenorhabditis Elegans. Molecules. 2020 Jan 15;25(2) PubMed PMID: 31952185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans. AU - Wang,Jing, AU - Deng,Na, AU - Wang,Hong, AU - Li,Tong, AU - Chen,Ling, AU - Zheng,Bisheng, AU - Liu,Rui Hai, Y1 - 2020/01/15/ PY - 2019/12/07/received PY - 2020/01/06/revised PY - 2020/01/07/accepted PY - 2020/1/19/entrez PY - 2020/1/19/pubmed PY - 2020/10/27/medline KW - C. elegans KW - anti-aging KW - antioxidant properties KW - orange extracts JF - Molecules (Basel, Switzerland) JO - Molecules VL - 25 IS - 2 N2 - Orange, with various bioactive phytochemicals, exerts various beneficial health effects, including anti-cancer, antioxidant, and anti-inflammatory properties. However, its anti-aging effects remain unclear. In this study, the Caenorhabditis elegans (C. elegans) model was used to evaluate the effects of orange extracts on lifespan and stress resistance. The results indicated that orange extracts dose-dependently increased the mean lifespan of C. elegans by 10.5%, 18.0%, and 26.2% at the concentrations of 100, 200, and 400 mg/mL, respectively. Meanwhile, orange extracts promoted the healthspan by improving motility, and decreasing the accumulation of age pigment and intracellular reactive oxygen species (ROS) levels without damaging fertility. The survival rates of orange extract-fed worms were obviously higher than those of untreated worms against thermal and ultraviolet-B (UV-B) stress. Moreover, the activities of superoxide dismutase (SOD) and catalase (CAT) were significantly enhanced while malondialdehyde (MDA) contents were diminished. Further investigation revealed that worms supplemented with orange extracts resulted in upregulated levels of genes, including daf-16, sod-3, gst-4, sek-1, and skn-1, and the downregulation of age-1 expression. These findings revealed that orange extracts have potential anti-aging effects through extending the lifespan, enhancing stress resistance, and promoting the healthspan. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/31952185/Effects_of_Orange_Extracts_on_Longevity_Healthspan_and_Stress_Resistance_in_Caenorhabditis_elegans_ L2 - https://www.mdpi.com/resolver?pii=molecules25020351 DB - PRIME DP - Unbound Medicine ER -