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Maternal urinary bisphenol A concentration and thyroid hormone levels of Chinese mothers and newborns by maternal body mass index.
Environ Sci Pollut Res Int. 2020 Apr; 27(10):10939-10949.ES

Abstract

Animal studies indicated that bisphenol A (BPA) exposure during pregnancy may disrupt thyroid function which is critical for fetal development. However, few epidemiological studies have examined this topic and the results were inconsistent. We aimed to evaluate whether prenatal BPA exposure is associated with thyroid hormone levels in Chinese mothers and newborns with stratification by maternal body mass index (BMI). BPA concentration were measured in urine samples collected from 555 women at late pregnancy. Maternal serum free thyroxin (FT4), thyroid-stimulating hormone (TSH) and thyroid peroxidase antibody (TPO-Ab) concentrations at the third trimester were abstracted from medical records. Cord serum-free triiodothyronine (FT3), FT4, TSH, and TPO-Ab levels were measured in 398 newborns. Prenatal urinary BPA was detected in 98.5% of mothers with a geometric mean of 1.32 ng/mL (95% CI 1.17-1.49 ng/mL). With each 10-fold increase in BPA concentrations, maternal log10_(TSH) mIU/L was 0.10 lowered (95% CI - 0.20, - 0.005, p < 0.05) among pre-pregnancy BMI > 23 kg/m2, with adjustment for maternal age, maternal education, gestation diabetes mellitus (GDM), husband smoking during pregnancy, parity, and gestational age at thyroid parameters measured, but no association was observed in pre-pregnancy BMI < 18.5, or 18.5-22.9 kg/m2 stratum. No BPA-associated changes were observed in maternal FT4 level or odds of positive TPO-Ab in all BMI stratum. Also, no associations were observed between prenatal urinary BPA concentration and cord serum FT4, FT3, TSH levels, and odds of positive TPO-Ab in both male and female newborns among pre-pregnancy BMI < 18.5, 18.5-22.9 or > 23 kg/m2 stratum. In this study, prenatal urinary BPA concentration was associated with lower maternal TSH among women with overweight, but not associated with other maternal thyroid parameters or cord serum thyroid parameters across maternal BMI categories. More research on pregnant women and newborns cohort with BPA exposure are warranted.

Authors+Show Affiliations

Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. Department of Neonatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.Exposure Dynamics Research Section, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, 305-8506, Japan.Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.Department of Neonatology, International Peace Maternal and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, 910 Heng Shan Road, Shanghai, 200030, China.Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. ouyangfengxiu@xinhuamed.com.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31953761

Citation

Wang, Xia, et al. "Maternal Urinary Bisphenol a Concentration and Thyroid Hormone Levels of Chinese Mothers and Newborns By Maternal Body Mass Index." Environmental Science and Pollution Research International, vol. 27, no. 10, 2020, pp. 10939-10949.
Wang X, Tang N, Nakayama SF, et al. Maternal urinary bisphenol A concentration and thyroid hormone levels of Chinese mothers and newborns by maternal body mass index. Environ Sci Pollut Res Int. 2020;27(10):10939-10949.
Wang, X., Tang, N., Nakayama, S. F., Fan, P., Liu, Z., Zhang, J., & Ouyang, F. (2020). Maternal urinary bisphenol A concentration and thyroid hormone levels of Chinese mothers and newborns by maternal body mass index. Environmental Science and Pollution Research International, 27(10), 10939-10949. https://doi.org/10.1007/s11356-020-07705-8
Wang X, et al. Maternal Urinary Bisphenol a Concentration and Thyroid Hormone Levels of Chinese Mothers and Newborns By Maternal Body Mass Index. Environ Sci Pollut Res Int. 2020;27(10):10939-10949. PubMed PMID: 31953761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal urinary bisphenol A concentration and thyroid hormone levels of Chinese mothers and newborns by maternal body mass index. AU - Wang,Xia, AU - Tang,Ning, AU - Nakayama,Shoji F, AU - Fan,Pianpian, AU - Liu,Zhiwei, AU - Zhang,Jun, AU - Ouyang,Fengxiu, Y1 - 2020/01/17/ PY - 2019/01/24/received PY - 2020/01/09/accepted PY - 2020/1/19/pubmed PY - 2020/7/11/medline PY - 2020/1/19/entrez KW - Birth cohort KW - Bisphenol A KW - China KW - Prenatal exposure KW - Thyroid hormone SP - 10939 EP - 10949 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 27 IS - 10 N2 - Animal studies indicated that bisphenol A (BPA) exposure during pregnancy may disrupt thyroid function which is critical for fetal development. However, few epidemiological studies have examined this topic and the results were inconsistent. We aimed to evaluate whether prenatal BPA exposure is associated with thyroid hormone levels in Chinese mothers and newborns with stratification by maternal body mass index (BMI). BPA concentration were measured in urine samples collected from 555 women at late pregnancy. Maternal serum free thyroxin (FT4), thyroid-stimulating hormone (TSH) and thyroid peroxidase antibody (TPO-Ab) concentrations at the third trimester were abstracted from medical records. Cord serum-free triiodothyronine (FT3), FT4, TSH, and TPO-Ab levels were measured in 398 newborns. Prenatal urinary BPA was detected in 98.5% of mothers with a geometric mean of 1.32 ng/mL (95% CI 1.17-1.49 ng/mL). With each 10-fold increase in BPA concentrations, maternal log10_(TSH) mIU/L was 0.10 lowered (95% CI - 0.20, - 0.005, p < 0.05) among pre-pregnancy BMI > 23 kg/m2, with adjustment for maternal age, maternal education, gestation diabetes mellitus (GDM), husband smoking during pregnancy, parity, and gestational age at thyroid parameters measured, but no association was observed in pre-pregnancy BMI < 18.5, or 18.5-22.9 kg/m2 stratum. No BPA-associated changes were observed in maternal FT4 level or odds of positive TPO-Ab in all BMI stratum. Also, no associations were observed between prenatal urinary BPA concentration and cord serum FT4, FT3, TSH levels, and odds of positive TPO-Ab in both male and female newborns among pre-pregnancy BMI < 18.5, 18.5-22.9 or > 23 kg/m2 stratum. In this study, prenatal urinary BPA concentration was associated with lower maternal TSH among women with overweight, but not associated with other maternal thyroid parameters or cord serum thyroid parameters across maternal BMI categories. More research on pregnant women and newborns cohort with BPA exposure are warranted. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/31953761/Maternal_urinary_bisphenol_A_concentration_and_thyroid_hormone_levels_of_Chinese_mothers_and_newborns_by_maternal_body_mass_index_ L2 - https://dx.doi.org/10.1007/s11356-020-07705-8 DB - PRIME DP - Unbound Medicine ER -