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Visual Acuity and Foveal Structure in Eyes with Fragmented Foveal Avascular Zones.
Ophthalmol Retina. 2020 05; 4(5):535-544.OR

Abstract

PURPOSE

To assess the frequency and impact of abnormal foveal avascular zone (FAZ) topography (i.e., a fragmented FAZ) on visual acuity and foveal anatomic features.

DESIGN

Prospective, cross-sectional study from March 2018 through July 2019.

PARTICIPANTS

Two-hundred fifty participants were screened from a normative OCT angiography database. Of those, 12 participants were found to have at least 1 eye with a fragmented FAZ. Eight returned for follow-up imaging, along with an additional 3 participants with ocular disease (amblyopia, autosomal recessive bestrophinopathy, premature birth) having a similar FAZ phenotype.

METHODS

Follow-up OCT imaging and monocular best-corrected visual acuity (BCVA) were performed for these 11 participants. Twenty-four participants with a clearly defined FAZ were recruited for comparison. A normative database was created measuring parafoveal intercapillary area (PICA) to determine if an FAZ was fragmented.

MAIN OUTCOME MEASURES

Monocular BCVA, foveal pit depth, foveal pit area, PICA, outer nuclear layer thickness, foveal inner retinal area, and peak cone density.

RESULTS

The frequency of a fragmented FAZ was 4.8% of individuals (12 of 250) or 3.6% of eyes (18 of 500 eyes). A significant difference was found between the control eyes and eyes with fragmented FAZs for foveal pit depth, pit area, and total PICA (P < 0.001, P = 0.002, and P < 0.001, respectively). The presence of a fragmented FAZ did not affect visual acuity.

CONCLUSIONS

The presence of a fragmented FAZ seems not to be a rare phenotype in individuals with normal vision. The presence of altered FAZ topography in patients with retinal or systemic disease could negatively impact the accuracy and sensitivity of biomarkers dependent on FAZ identification.

Authors+Show Affiliations

Department of Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin.Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.Department of Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin.Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York; Icahn School of Medicine at Mount Sinai, New York, New York.Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York; Icahn School of Medicine at Mount Sinai, New York, New York.Department of Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address: jcarroll@mcw.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31956075

Citation

Linderman, Rachel E., et al. "Visual Acuity and Foveal Structure in Eyes With Fragmented Foveal Avascular Zones." Ophthalmology. Retina, vol. 4, no. 5, 2020, pp. 535-544.
Linderman RE, Cava JA, Salmon AE, et al. Visual Acuity and Foveal Structure in Eyes with Fragmented Foveal Avascular Zones. Ophthalmol Retina. 2020;4(5):535-544.
Linderman, R. E., Cava, J. A., Salmon, A. E., Chui, T. Y., Marmorstein, A. D., Lujan, B. J., Rosen, R. B., & Carroll, J. (2020). Visual Acuity and Foveal Structure in Eyes with Fragmented Foveal Avascular Zones. Ophthalmology. Retina, 4(5), 535-544. https://doi.org/10.1016/j.oret.2019.11.014
Linderman RE, et al. Visual Acuity and Foveal Structure in Eyes With Fragmented Foveal Avascular Zones. Ophthalmol Retina. 2020;4(5):535-544. PubMed PMID: 31956075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visual Acuity and Foveal Structure in Eyes with Fragmented Foveal Avascular Zones. AU - Linderman,Rachel E, AU - Cava,Jenna A, AU - Salmon,Alexander E, AU - Chui,Toco Y, AU - Marmorstein,Alan D, AU - Lujan,Brandon J, AU - Rosen,Richard B, AU - Carroll,Joseph, Y1 - 2019/11/22/ PY - 2019/06/24/received PY - 2019/11/08/revised PY - 2019/11/15/accepted PY - 2020/1/21/pubmed PY - 2021/5/20/medline PY - 2020/1/21/entrez SP - 535 EP - 544 JF - Ophthalmology. Retina JO - Ophthalmol Retina VL - 4 IS - 5 N2 - PURPOSE: To assess the frequency and impact of abnormal foveal avascular zone (FAZ) topography (i.e., a fragmented FAZ) on visual acuity and foveal anatomic features. DESIGN: Prospective, cross-sectional study from March 2018 through July 2019. PARTICIPANTS: Two-hundred fifty participants were screened from a normative OCT angiography database. Of those, 12 participants were found to have at least 1 eye with a fragmented FAZ. Eight returned for follow-up imaging, along with an additional 3 participants with ocular disease (amblyopia, autosomal recessive bestrophinopathy, premature birth) having a similar FAZ phenotype. METHODS: Follow-up OCT imaging and monocular best-corrected visual acuity (BCVA) were performed for these 11 participants. Twenty-four participants with a clearly defined FAZ were recruited for comparison. A normative database was created measuring parafoveal intercapillary area (PICA) to determine if an FAZ was fragmented. MAIN OUTCOME MEASURES: Monocular BCVA, foveal pit depth, foveal pit area, PICA, outer nuclear layer thickness, foveal inner retinal area, and peak cone density. RESULTS: The frequency of a fragmented FAZ was 4.8% of individuals (12 of 250) or 3.6% of eyes (18 of 500 eyes). A significant difference was found between the control eyes and eyes with fragmented FAZs for foveal pit depth, pit area, and total PICA (P < 0.001, P = 0.002, and P < 0.001, respectively). The presence of a fragmented FAZ did not affect visual acuity. CONCLUSIONS: The presence of a fragmented FAZ seems not to be a rare phenotype in individuals with normal vision. The presence of altered FAZ topography in patients with retinal or systemic disease could negatively impact the accuracy and sensitivity of biomarkers dependent on FAZ identification. SN - 2468-6530 UR - https://www.unboundmedicine.com/medline/citation/31956075/Visual_Acuity_and_Foveal_Structure_in_Eyes_with_Fragmented_Foveal_Avascular_Zones_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2468-6530(19)30648-7 DB - PRIME DP - Unbound Medicine ER -