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[A case of neuromyelitis optica spectrum disorder with persistent nausea and repeated syncope].
Rinsho Shinkeigaku. 2020 Jan 19 [Online ahead of print]RS

Abstract

A 22-year-old woman was admitted to our hospital with persistent nausea and no apparent cause. There was no preceding infection. The patient lost consciousness for several seconds. Based on an electrocardiographic diagnosis of paroxysmal sinus arrest (PSA), a temporary pacemaker was implanted. She did not develop syncope, but vertigo, nystagmus, diplopia, and limb paresthesia were observed. Brain MRI revealed a high-intensity lesion in the dorsal medulla on FLAIR images. As the serum anti-aquaporin 4 (AQP4) antibody was positive, the patient was diagnosed with neuromyelitis optica spectrum disorder (NMOSD). After she received steroid pulse therapy (methylprednisolone at 1,000 mg/day for three days) twice, her symptoms markedly improved. In this patient, PSA was considered to be a symptom of area postrema syndrome of NMOSD. Therefore, NMOSD should be considered as a possible cause of PSA.

Authors+Show Affiliations

Department of Neurology, Fukui-ken Saiseikai Hospital. Department of Neurology, University of Fukui Hospital.Department of Neurology, Fukui-ken Saiseikai Hospital. Department of Neurology, University of Fukui Hospital. Department of Rehabilitation, Faculty of Health Science, Fukui Health Science University.Department of Neurology, University of Fukui Hospital.Department of Neurology, University of Fukui Hospital.Department of Cardiology, Fukui-ken Saiseikai Hospital.Department of Neurology, University of Fukui Hospital. Department of Aging and Dementia (DAD), Faculty of Medical Sciences, University of Fukui.

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

31956194

Citation

Endo, Yoshinori, et al. "[A Case of Neuromyelitis Optica Spectrum Disorder With Persistent Nausea and Repeated Syncope]." Rinsho Shinkeigaku = Clinical Neurology, 2020.
Endo Y, Hayashi K, Ikawa M, et al. [A case of neuromyelitis optica spectrum disorder with persistent nausea and repeated syncope]. Rinsho Shinkeigaku. 2020.
Endo, Y., Hayashi, K., Ikawa, M., Yamamura, O., Ookura, K., & Hamano, T. (2020). [A case of neuromyelitis optica spectrum disorder with persistent nausea and repeated syncope]. Rinsho Shinkeigaku = Clinical Neurology. https://doi.org/10.5692/clinicalneurol.cn-001345
Endo Y, et al. [A Case of Neuromyelitis Optica Spectrum Disorder With Persistent Nausea and Repeated Syncope]. Rinsho Shinkeigaku. 2020 Jan 19; PubMed PMID: 31956194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A case of neuromyelitis optica spectrum disorder with persistent nausea and repeated syncope]. AU - Endo,Yoshinori, AU - Hayashi,Kouji, AU - Ikawa,Masamichi, AU - Yamamura,Osamu, AU - Ookura,Kiyotaka, AU - Hamano,Tadanori, Y1 - 2020/01/19/ PY - 2020/1/21/entrez KW - NMO spectrum disorder KW - area postrema syndrome KW - persistent nausea KW - sinus arrest KW - syncope JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku N2 - A 22-year-old woman was admitted to our hospital with persistent nausea and no apparent cause. There was no preceding infection. The patient lost consciousness for several seconds. Based on an electrocardiographic diagnosis of paroxysmal sinus arrest (PSA), a temporary pacemaker was implanted. She did not develop syncope, but vertigo, nystagmus, diplopia, and limb paresthesia were observed. Brain MRI revealed a high-intensity lesion in the dorsal medulla on FLAIR images. As the serum anti-aquaporin 4 (AQP4) antibody was positive, the patient was diagnosed with neuromyelitis optica spectrum disorder (NMOSD). After she received steroid pulse therapy (methylprednisolone at 1,000 mg/day for three days) twice, her symptoms markedly improved. In this patient, PSA was considered to be a symptom of area postrema syndrome of NMOSD. Therefore, NMOSD should be considered as a possible cause of PSA. SN - 1882-0654 UR - https://www.unboundmedicine.com/medline/citation/31956194/[A_case_of_neuromyelitis_optica_spectrum_disorder_with_persistent_nausea_and_repeated_syncope] L2 - https://dx.doi.org/10.5692/clinicalneurol.cn-001345 DB - PRIME DP - Unbound Medicine ER -
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