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Naringenin mitigates antituberculosis drugs induced hepatic and renal injury in rats.
J Tradit Complement Med 2020; 10(1):26-35JT

Abstract

Tuberculosis is one of the deadly diseases, which can be well treated by antituberculosis drugs (ATDs) i.e. isoniazid, rifampicin, pyrazinamide and ethambutol. These drugs also lead to severe hepatic and renal injury. The present study was designed to investigate efficacy of naringenin against ATDs induced hepato-renal injury. Rats were administered with ATDs for 8 weeks (3 day/week) followed by naringenin at three different doses (10, 20 and 40 mg/kg) conjointly for 8 weeks (3 days/week) orally. Silymarin (50 mg/kg) was used as positive control in the study. Hepatic and renal injury was measured by increased level of serological parameters such as aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, bilirubin, urea, uric acid and creatinine. The toxic effect of ATDs was also indicated by significant increase in lipid peroxidation along with decline in GSH, catalase and superoxide dismutase activity in liver and kidney tissues. Treatment with naringenin encountered ATDs induced injury as evident by significant reversal of biochemical indices towards their respective control in a dose dependent manner. Histopathological observations also supported biochemical findings. Assessment of TNF-α indicated therapeutic efficacy of naringenin at molecular level. Thus, results of this study clearly showed that naringenin possess protective role against ATDs induced hepato-renal injury and to take naringenin supplementation as food may be worthwhile to reduce ATDs induced hepato-renal injury.

Authors+Show Affiliations

Toxicology and Pharmacology Laboratory, Department of Zoology, Guru Ghasidas University, Bilaspur, 495009 (CG), India.Toxicology and Pharmacology Laboratory, Department of Zoology, Guru Ghasidas University, Bilaspur, 495009 (CG), India.Toxicology and Pharmacology Laboratory, Department of Zoology, Guru Ghasidas University, Bilaspur, 495009 (CG), India.Laboratory of Natural Products, Department of Rural Technology and Social Development, Guru Ghasidas University, Bilaspur, 495009 (CG), India.Toxicology and Pharmacology Laboratory, Department of Zoology, Guru Ghasidas University, Bilaspur, 495009 (CG), India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31956555

Citation

Sahu, Nisha, et al. "Naringenin Mitigates Antituberculosis Drugs Induced Hepatic and Renal Injury in Rats." Journal of Traditional and Complementary Medicine, vol. 10, no. 1, 2020, pp. 26-35.
Sahu N, Mishra G, Chandra HK, et al. Naringenin mitigates antituberculosis drugs induced hepatic and renal injury in rats. J Tradit Complement Med. 2020;10(1):26-35.
Sahu, N., Mishra, G., Chandra, H. K., Nirala, S. K., & Bhadauria, M. (2020). Naringenin mitigates antituberculosis drugs induced hepatic and renal injury in rats. Journal of Traditional and Complementary Medicine, 10(1), pp. 26-35. doi:10.1016/j.jtcme.2019.01.001.
Sahu N, et al. Naringenin Mitigates Antituberculosis Drugs Induced Hepatic and Renal Injury in Rats. J Tradit Complement Med. 2020;10(1):26-35. PubMed PMID: 31956555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Naringenin mitigates antituberculosis drugs induced hepatic and renal injury in rats. AU - Sahu,Nisha, AU - Mishra,Gita, AU - Chandra,Hemeshwer Kumar, AU - Nirala,Satendra Kumar, AU - Bhadauria,Monika, Y1 - 2019/01/12/ PY - 2018/07/16/received PY - 2019/01/02/revised PY - 2019/01/03/accepted PY - 2020/1/21/entrez PY - 2020/1/21/pubmed PY - 2020/1/21/medline KW - Antioxidant activity KW - Antituberculosis drugs KW - Hepato-renal injury KW - Histopathology KW - Naringenin KW - Oxidative stress SP - 26 EP - 35 JF - Journal of traditional and complementary medicine JO - J Tradit Complement Med VL - 10 IS - 1 N2 - Tuberculosis is one of the deadly diseases, which can be well treated by antituberculosis drugs (ATDs) i.e. isoniazid, rifampicin, pyrazinamide and ethambutol. These drugs also lead to severe hepatic and renal injury. The present study was designed to investigate efficacy of naringenin against ATDs induced hepato-renal injury. Rats were administered with ATDs for 8 weeks (3 day/week) followed by naringenin at three different doses (10, 20 and 40 mg/kg) conjointly for 8 weeks (3 days/week) orally. Silymarin (50 mg/kg) was used as positive control in the study. Hepatic and renal injury was measured by increased level of serological parameters such as aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, bilirubin, urea, uric acid and creatinine. The toxic effect of ATDs was also indicated by significant increase in lipid peroxidation along with decline in GSH, catalase and superoxide dismutase activity in liver and kidney tissues. Treatment with naringenin encountered ATDs induced injury as evident by significant reversal of biochemical indices towards their respective control in a dose dependent manner. Histopathological observations also supported biochemical findings. Assessment of TNF-α indicated therapeutic efficacy of naringenin at molecular level. Thus, results of this study clearly showed that naringenin possess protective role against ATDs induced hepato-renal injury and to take naringenin supplementation as food may be worthwhile to reduce ATDs induced hepato-renal injury. SN - 2225-4110 UR - https://www.unboundmedicine.com/medline/citation/31956555/Naringenin_mitigates_antituberculosis_drugs_induced_hepatic_and_renal_injury_in_rats L2 - https://linkinghub.elsevier.com/retrieve/pii/S2225-4110(18)30290-6 DB - PRIME DP - Unbound Medicine ER -