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From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading.
Bioact Mater 2020; 5(1):17-25BM

Abstract

Integration of two or more biomolecules with synergetic and complementary effects on a material surface can help to obtain multi-functions for various biomedical applications. However, the amounts of biomolecules integrated and their physiological functions are compromised due to the limited surface anchoring sites. Herein, we propose a novel concept of film engineering strategy "from surface to bulk synergetic modification". This new concept is realized by employing the surface amine groups of plasma polymerized allylamine (PPAm) film for grafting a molecule e.g., thrombin inhibitor, bivalirudin (BVLD), meanwhile its bulk amine groups is used as a universal depot for storing and releasing therapeutic nitric oxide (NO) gas as supplement to the functions of BVLD. It is demonstrated that such a "from surface to bulk synergetic modification" film engineering can impart the modified-substrates with anti-platelet and anti-coagulant dual functions, giving rise to a highly endothelium-mimetic thromboresistant property. We believe that our research provides a very promising strategy to deliver multifunctional surface versatilely that require NO release in combination with other properties, which will find broad biomedical applications in blood-contacting devices, and et al. Moreover, it also provides a brand-new film engineering strategy for tailoring surface multi-functionalities of a wide range of materials.

Authors+Show Affiliations

Key Laboratory of Advanced Technology for Materials of the Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.Key Laboratory of Advanced Technology for Materials of the Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.Key Laboratory of Advanced Technology for Materials of the Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.Key Laboratory of Advanced Technology for Materials of the Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.Key Laboratory of Advanced Technology for Materials of the Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.Key Laboratory of Advanced Technology for Materials of the Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.Key Laboratory of Advanced Technology for Materials of the Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.Key Laboratory of Advanced Technology for Materials of the Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31956732

Citation

Yang, Tong, et al. "From Surface to Bulk Modification: Plasma Polymerization of Amine-bearing Coating By Synergic Strategy of Biomolecule Grafting and Nitric Oxide Loading." Bioactive Materials, vol. 5, no. 1, 2020, pp. 17-25.
Yang T, Du Z, Qiu H, et al. From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading. Bioact Mater. 2020;5(1):17-25.
Yang, T., Du, Z., Qiu, H., Gao, P., Zhao, X., Wang, H., ... Yang, Z. (2020). From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading. Bioactive Materials, 5(1), pp. 17-25. doi:10.1016/j.bioactmat.2019.12.006.
Yang T, et al. From Surface to Bulk Modification: Plasma Polymerization of Amine-bearing Coating By Synergic Strategy of Biomolecule Grafting and Nitric Oxide Loading. Bioact Mater. 2020;5(1):17-25. PubMed PMID: 31956732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading. AU - Yang,Tong, AU - Du,Zeyu, AU - Qiu,Hua, AU - Gao,Peng, AU - Zhao,Xin, AU - Wang,Huaiyu, AU - Tu,Qiufen, AU - Xiong,Kaiqin, AU - Huang,Nan, AU - Yang,Zhilu, Y1 - 2020/01/11/ PY - 2019/12/17/received PY - 2019/12/23/accepted PY - 2020/1/21/entrez PY - 2020/1/21/pubmed PY - 2020/1/21/medline KW - Amine-bearing coating KW - Biomolecule grafting KW - Nitric oxide loading KW - Surface chemistry KW - Synergic modification SP - 17 EP - 25 JF - Bioactive materials JO - Bioact Mater VL - 5 IS - 1 N2 - Integration of two or more biomolecules with synergetic and complementary effects on a material surface can help to obtain multi-functions for various biomedical applications. However, the amounts of biomolecules integrated and their physiological functions are compromised due to the limited surface anchoring sites. Herein, we propose a novel concept of film engineering strategy "from surface to bulk synergetic modification". This new concept is realized by employing the surface amine groups of plasma polymerized allylamine (PPAm) film for grafting a molecule e.g., thrombin inhibitor, bivalirudin (BVLD), meanwhile its bulk amine groups is used as a universal depot for storing and releasing therapeutic nitric oxide (NO) gas as supplement to the functions of BVLD. It is demonstrated that such a "from surface to bulk synergetic modification" film engineering can impart the modified-substrates with anti-platelet and anti-coagulant dual functions, giving rise to a highly endothelium-mimetic thromboresistant property. We believe that our research provides a very promising strategy to deliver multifunctional surface versatilely that require NO release in combination with other properties, which will find broad biomedical applications in blood-contacting devices, and et al. Moreover, it also provides a brand-new film engineering strategy for tailoring surface multi-functionalities of a wide range of materials. SN - 2452-199X UR - https://www.unboundmedicine.com/medline/citation/31956732/From_surface_to_bulk_modification:_Plasma_polymerization_of_amine-bearing_coating_by_synergic_strategy_of_biomolecule_grafting_and_nitric_oxide_loading L2 - https://linkinghub.elsevier.com/retrieve/pii/S2452-199X(19)30074-X DB - PRIME DP - Unbound Medicine ER -