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Harnessing bacterial interactions to manage infections: a review on the opportunistic pathogen Pseudomonas aeruginosa as a case example.

Abstract

During infections, bacterial pathogens can engage in a variety of interactions with each other, ranging from the cooperative sharing of resources to deadly warfare. This is especially relevant in opportunistic infections, where different strains and species often co-infect the same patient and interact in the host. Here, we review the relevance of these social interactions during opportunistic infections using the human pathogen Pseudomonas aeruginosa as a case example. In particular, we discuss different types of pathogen-pathogen interactions, involving both cooperation and competition, and elaborate on how they impact virulence in multi-strain and multi-species infections. We then review evolutionary dynamics within pathogen populations during chronic infections. We particuarly discuss how local adaptation through niche separation, evolutionary successions and antagonistic co-evolution between pathogens can alter virulence and the damage inflicted on the host. Finally, we outline how studying bacterial social dynamics could be used to manage infections. We show that a deeper appreciation of bacterial evolution and ecology in the clinical context is important for understanding microbial infections and can inspire novel treatment strategies.

Authors+Show Affiliations

Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.Department of Biochemistry, University of Oxford, Oxford, UK. Department of Zoology, University of Oxford, Oxford, UK.Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31961787

Citation

Rezzoagli, Chiara, et al. "Harnessing Bacterial Interactions to Manage Infections: a Review On the Opportunistic Pathogen Pseudomonas Aeruginosa as a Case Example." Journal of Medical Microbiology, 2020.
Rezzoagli C, Granato ET, Kümmerli R. Harnessing bacterial interactions to manage infections: a review on the opportunistic pathogen Pseudomonas aeruginosa as a case example. J Med Microbiol. 2020.
Rezzoagli, C., Granato, E. T., & Kümmerli, R. (2020). Harnessing bacterial interactions to manage infections: a review on the opportunistic pathogen Pseudomonas aeruginosa as a case example. Journal of Medical Microbiology, doi:10.1099/jmm.0.001134.
Rezzoagli C, Granato ET, Kümmerli R. Harnessing Bacterial Interactions to Manage Infections: a Review On the Opportunistic Pathogen Pseudomonas Aeruginosa as a Case Example. J Med Microbiol. 2020 Jan 21; PubMed PMID: 31961787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Harnessing bacterial interactions to manage infections: a review on the opportunistic pathogen Pseudomonas aeruginosa as a case example. AU - Rezzoagli,Chiara, AU - Granato,Elisa T, AU - Kümmerli,Rolf, Y1 - 2020/01/21/ PY - 2020/1/22/entrez PY - 2020/1/22/pubmed PY - 2020/1/22/medline KW - Pseudomonas aeruginosa KW - alternative treatments KW - ecology and evolution KW - infections KW - polymicrobial infections KW - social interactions KW - sociomicrobiology JF - Journal of medical microbiology JO - J. Med. Microbiol. N2 - During infections, bacterial pathogens can engage in a variety of interactions with each other, ranging from the cooperative sharing of resources to deadly warfare. This is especially relevant in opportunistic infections, where different strains and species often co-infect the same patient and interact in the host. Here, we review the relevance of these social interactions during opportunistic infections using the human pathogen Pseudomonas aeruginosa as a case example. In particular, we discuss different types of pathogen-pathogen interactions, involving both cooperation and competition, and elaborate on how they impact virulence in multi-strain and multi-species infections. We then review evolutionary dynamics within pathogen populations during chronic infections. We particuarly discuss how local adaptation through niche separation, evolutionary successions and antagonistic co-evolution between pathogens can alter virulence and the damage inflicted on the host. Finally, we outline how studying bacterial social dynamics could be used to manage infections. We show that a deeper appreciation of bacterial evolution and ecology in the clinical context is important for understanding microbial infections and can inspire novel treatment strategies. SN - 1473-5644 UR - https://www.unboundmedicine.com/medline/citation/31961787/Harnessing_bacterial_interactions_to_manage_infections:_a_review_on_the_opportunistic_pathogen_Pseudomonas_aeruginosa_as_a_case_example L2 - http://jmm.microbiologyresearch.org/pubmed/content/journal/jmm/10.1099/jmm.0.001134 DB - PRIME DP - Unbound Medicine ER -