Tags

Type your tag names separated by a space and hit enter

Fournier's gangrene mortality; A 17- year systematic review and meta-analysis.

Abstract

BACKGROUND

To provide better management of the disease, mortality-associated comorbidities, and common etiologies were identified.

METHOD

Systematic search was conducted through twelve databases, followed by meticulous screening to select relevant articles. Meta-analysis and meta-regression (for possible cofounders) were both done for all possible outcomes.

RESULT

Out of 1186 reports screened, we finally included 38 studies for our systematic review and meta-analysis. A higher risk of mortality was detected in patients with diabetes, heart disease, renal failure and kidney disease with the risk ratio (RR) and 95% confidence interval of 0.72 (95%CI 0.59-0.89), 0.39 (0.24-0.62), 0.41 (95%CI 0.27-0.63) and 0.34 (95%CI 0.16-0.73), respectively. However, there was no association between mortality rates and co-morbid hypertension, lung disease, liver disease and malignant disease (p > 0.05). The highest mortality rates were due to sepsis (76%) and multiple organ failure (66%), followed by the observed mortality rates due to respiratory (19.4%), renal (18%), cardiovascular (15.7%) and hepatic (5%).

CONCLUSION

Modifications in Fournier Gangrene Severity Index (FGSI), to include comorbidities as an important prognostic tool for FG mortality, are recommended. Close monitoring of the patients, with special interest given to the main causes of mortality, is an essential element of the management process.

Authors+Show Affiliations

Faculty of Medicine, Minia University, Minia 61519, Egypt. Electronic address: amrehab11111@gmail.com.Kasr Alainy Faculty of Medicine, Cairo University, Egypt. Electronic address: khalidmkhalaf96@gmail.com.Faculty of Medicine, Minia University, Minia 61519, Egypt. Electronic address: abdullahdahy@gmail.com.Faculty of Medicine, Minia University, Minia 61519, Egypt. Electronic address: abdoarmmm98@gmail.com.Faculty of Medicine, University of Algiers, Algeria. Electronic address: amira.yasmine.benmelouka@gmail.com.Faculty of Medicine, Mansoura University, Mansoura, Egypt; Neurosurgery Department, El Sheikh Zayed Specialized Hospital, Giza, Egypt. Electronic address: sherief_ghozy@yahoo.com.Faculty of Pharmacy, Deraya University, Minya 61519, Egypt. Electronic address: mohamedusama808@gmail.com.Biology Department, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. Electronic address: may_binjumah@outlook.com.Department of Zoology, Science College, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: salkahtani@ksu.edu.sa.Department of Zoology, Science College, King Saud University, Riyadh 11451, Saudi Arabia; Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. Electronic address: abdeldaim.m@vet.suez.edu.eg.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31962181

Citation

El-Qushayri, Amr Ehab, et al. "Fournier's Gangrene Mortality; a 17- Year Systematic Review and Meta-analysis." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 2020.
El-Qushayri AE, Khalaf KM, Dahy A, et al. Fournier's gangrene mortality; A 17- year systematic review and meta-analysis. Int J Infect Dis. 2020.
El-Qushayri, A. E., Khalaf, K. M., Dahy, A., Mahmoud, A. R., Benmelouka, A. Y., Ghozy, S., ... Abdel-Daim, M. M. (2020). Fournier's gangrene mortality; A 17- year systematic review and meta-analysis. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, doi:10.1016/j.ijid.2019.12.030.
El-Qushayri AE, et al. Fournier's Gangrene Mortality; a 17- Year Systematic Review and Meta-analysis. Int J Infect Dis. 2020 Jan 18; PubMed PMID: 31962181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fournier's gangrene mortality; A 17- year systematic review and meta-analysis. AU - El-Qushayri,Amr Ehab, AU - Khalaf,Khalid Muhammad, AU - Dahy,Abdullah, AU - Mahmoud,Abdalla Reda, AU - Benmelouka,Amira Yasmine, AU - Ghozy,Sherief, AU - Mahmoud,Mohamed Usama, AU - Bin-Jumah,May, AU - Alkahtani,Saad, AU - Abdel-Daim,Mohamed M, Y1 - 2020/01/18/ PY - 2019/11/14/received PY - 2019/12/18/revised PY - 2019/12/21/accepted PY - 2020/1/22/entrez PY - 2020/1/22/pubmed PY - 2020/1/22/medline KW - Fournier’s gangrene KW - mortality KW - systematic review JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int. J. Infect. Dis. N2 - BACKGROUND: To provide better management of the disease, mortality-associated comorbidities, and common etiologies were identified. METHOD: Systematic search was conducted through twelve databases, followed by meticulous screening to select relevant articles. Meta-analysis and meta-regression (for possible cofounders) were both done for all possible outcomes. RESULT: Out of 1186 reports screened, we finally included 38 studies for our systematic review and meta-analysis. A higher risk of mortality was detected in patients with diabetes, heart disease, renal failure and kidney disease with the risk ratio (RR) and 95% confidence interval of 0.72 (95%CI 0.59-0.89), 0.39 (0.24-0.62), 0.41 (95%CI 0.27-0.63) and 0.34 (95%CI 0.16-0.73), respectively. However, there was no association between mortality rates and co-morbid hypertension, lung disease, liver disease and malignant disease (p > 0.05). The highest mortality rates were due to sepsis (76%) and multiple organ failure (66%), followed by the observed mortality rates due to respiratory (19.4%), renal (18%), cardiovascular (15.7%) and hepatic (5%). CONCLUSION: Modifications in Fournier Gangrene Severity Index (FGSI), to include comorbidities as an important prognostic tool for FG mortality, are recommended. Close monitoring of the patients, with special interest given to the main causes of mortality, is an essential element of the management process. SN - 1878-3511 UR - https://www.unboundmedicine.com/medline/citation/31962181/Fournier's_gangrene_mortality L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(19)30503-X DB - PRIME DP - Unbound Medicine ER -