Tags

Type your tag names separated by a space and hit enter

Association between Aldose Reductase Gene C(-106)T Polymorphism and Diabetic Retinopathy: A Systematic Review and Meta-Analysis.
Ophthalmic Res 2020; :1-10OR

Abstract

Controversial results regarding the associations between aldose reductase (AR) genetic polymorphisms and diabetic retinopathy (DR) have been reported for many years. The present meta-analysis was performed to clarify the effects of the AR gene C(-106)T polymorphism on DR risk. The PubMed, Web of Sciences, Cochrane library, EMBASE, Chinese National Knowledge Infrastructure, and Wan Fang databases were extensively searched in Chinese to select relevant studies with an updated date of April 25, 2018. The Newcastle-Ottawa Scale (NOS) was applied to assess quality. The random-effects model was applied to calculate the pooled OR and 95% CI. This meta-analysis identified 23 studies with an average score of 7.52 for NOS analysis, including 4,313 DR cases and 5,128 diabetes mellitus (DM) control cases. In the overall analysis, a significant association between the AR gene C(-106)T polymorphism and DR susceptibility was found. In subgroups stratified by DM type and ethnicity, significantly increased risks for DR were found in DM type 1, East Asian populations, and Middle Eastern populations. Compared with DR control cases, the following associations were found: T vs. C: OR 0.91, 95% CI 0.85-0.97, I2 = 72.9%; CT + TT vs. CC: OR 0.75, 95% CI 0.68-0.81, I2 = 86.7%; and CT vs. CC: OR 0.86, 95% CI 0.78-0.94, I2 = 70.5%. The results of this meta-analysis showed a significant association between the AR gene C(-106)T polymorphism and susceptibility to DR in DM patients. DM patients with allele T and CT+TT genotype of the AR gene may have a lower risk of DR.

Authors+Show Affiliations

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, Shenzhen University School of Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen, China. Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, Shenzhen University School of Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen, China. Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, Shenzhen University School of Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen, China.Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, Shenzhen University School of Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen, China.Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, Shenzhen University School of Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen, China.Imaging Department, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China.Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, Shenzhen University School of Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen, China.Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, Shenzhen University School of Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen, China, lishamou@gmail.com.

Pub Type(s)

Meta-Analysis

Language

eng

PubMed ID

31962334

Citation

Lin, Shan, et al. "Association Between Aldose Reductase Gene C(-106)T Polymorphism and Diabetic Retinopathy: a Systematic Review and Meta-Analysis." Ophthalmic Research, 2020, pp. 1-10.
Lin S, Peng Y, Cao M, et al. Association between Aldose Reductase Gene C(-106)T Polymorphism and Diabetic Retinopathy: A Systematic Review and Meta-Analysis. Ophthalmic Res. 2020.
Lin, S., Peng, Y., Cao, M., Chen, R., Hu, J., Pu, Z., ... Mou, L. (2020). Association between Aldose Reductase Gene C(-106)T Polymorphism and Diabetic Retinopathy: A Systematic Review and Meta-Analysis. Ophthalmic Research, pp. 1-10. doi:10.1159/000503972.
Lin S, et al. Association Between Aldose Reductase Gene C(-106)T Polymorphism and Diabetic Retinopathy: a Systematic Review and Meta-Analysis. Ophthalmic Res. 2020 Jan 21;1-10. PubMed PMID: 31962334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Aldose Reductase Gene C(-106)T Polymorphism and Diabetic Retinopathy: A Systematic Review and Meta-Analysis. AU - Lin,Shan, AU - Peng,Yuanzheng, AU - Cao,Mengtao, AU - Chen,Ruiting, AU - Hu,Jiying, AU - Pu,Zuhui, AU - Cai,Zhiming, AU - Mou,Lisha, Y1 - 2020/01/21/ PY - 2019/04/24/received PY - 2019/10/07/accepted PY - 2020/1/22/entrez PY - 2020/1/22/pubmed PY - 2020/1/22/medline KW - Aldose reductase KW - Diabetes mellitus KW - Diabetic retinopathy KW - Genetic polymorphism KW - Genotype SP - 1 EP - 10 JF - Ophthalmic research JO - Ophthalmic Res. N2 - Controversial results regarding the associations between aldose reductase (AR) genetic polymorphisms and diabetic retinopathy (DR) have been reported for many years. The present meta-analysis was performed to clarify the effects of the AR gene C(-106)T polymorphism on DR risk. The PubMed, Web of Sciences, Cochrane library, EMBASE, Chinese National Knowledge Infrastructure, and Wan Fang databases were extensively searched in Chinese to select relevant studies with an updated date of April 25, 2018. The Newcastle-Ottawa Scale (NOS) was applied to assess quality. The random-effects model was applied to calculate the pooled OR and 95% CI. This meta-analysis identified 23 studies with an average score of 7.52 for NOS analysis, including 4,313 DR cases and 5,128 diabetes mellitus (DM) control cases. In the overall analysis, a significant association between the AR gene C(-106)T polymorphism and DR susceptibility was found. In subgroups stratified by DM type and ethnicity, significantly increased risks for DR were found in DM type 1, East Asian populations, and Middle Eastern populations. Compared with DR control cases, the following associations were found: T vs. C: OR 0.91, 95% CI 0.85-0.97, I2 = 72.9%; CT + TT vs. CC: OR 0.75, 95% CI 0.68-0.81, I2 = 86.7%; and CT vs. CC: OR 0.86, 95% CI 0.78-0.94, I2 = 70.5%. The results of this meta-analysis showed a significant association between the AR gene C(-106)T polymorphism and susceptibility to DR in DM patients. DM patients with allele T and CT+TT genotype of the AR gene may have a lower risk of DR. SN - 1423-0259 UR - https://www.unboundmedicine.com/medline/citation/31962334/Association_between_Aldose_Reductase_Gene_C(-106)T_Polymorphism_and_Diabetic_Retinopathy:_A_Systematic_Review_and_Meta-Analysis L2 - https://www.karger.com?DOI=10.1159/000503972 DB - PRIME DP - Unbound Medicine ER -