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Evaluating a pragmatic estimate of insulin sensitivity in Latino youth with obesity.
Clin Obes 2020CO

Abstract

The whole-body insulin sensitivity index (WBISI) is a widely used surrogate of insulin sensitivity estimated from glucose and insulin concentrations during an oral glucose tolerance test (OGTT). The original WBISI uses five timepoints but reduced sampling models have been proposed. These reduced models have not been applied to the paediatric population. The purpose of this study is to compare cross-sectional agreement and changes in response to lifestyle intervention between the original WBISI and the WBISI120 using fasting and 2-hour glucose and insulin concentrations from OGTT among Latino adolescents with obesity. We also examined the cost-differential between the two measures. Secondary analyses were conducted with data from Latino adolescents (14-16 years) with obesity (BMI ≥ 95th percentile) who were recruited for a randomized controlled lifestyle intervention trial. Baseline data in youth (n = 148) who underwent a 2-hour OGTT was used to analyse agreement between WBISI and WBISI120 . Data from 65 participants who completed a 12-week lifestyle intervention were used to assess changes and the rate of change between WBISI and WBISI120 . Research costs to determine both measures were compared. WBISI120 showed good cross-sectional agreement (ICCagreement = 0.88) with the full WBISI. Following intervention, WBISI120 increased 62.5% (M ± SD, 1.6 ± 1.2 to 2.6 ± 1.7, P < .001) while WBISI increased by 25.0% (1.6 ± 1.0 to 2.0 ± 1.0, P < .001) but the rate of change for WBISI and WBISI120 was not significantly different (P = .11). WBISI120 costs ~70% less than WBISI. WBISI120 may offer a cost-effective surrogate estimate of insulin sensitivity in Latino youth with obesity.

Authors+Show Affiliations

Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, Arizona. College of Health Solutions, Arizona State University, Phoenix, Arizona.Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, Arizona. Department of Pediatric Endocrinology and Diabetes, Phoenix Children's Hospital, Phoenix, Arizona.Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, Arizona. Southwest Interdisciplinary Research Center, Arizona State University, Phoenix, Arizona.College of Health Solutions, Arizona State University, Phoenix, Arizona.College of Health Solutions, Arizona State University, Phoenix, Arizona.Southwest Interdisciplinary Research Center, Arizona State University, Phoenix, Arizona.Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, Arizona. College of Health Solutions, Arizona State University, Phoenix, Arizona. Department of Pediatric Endocrinology and Diabetes, Phoenix Children's Hospital, Phoenix, Arizona. Southwest Interdisciplinary Research Center, Arizona State University, Phoenix, Arizona.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31962378

Citation

Peña, Armando, et al. "Evaluating a Pragmatic Estimate of Insulin Sensitivity in Latino Youth With Obesity." Clinical Obesity, 2020.
Peña A, Olson ML, Soltero EG, et al. Evaluating a pragmatic estimate of insulin sensitivity in Latino youth with obesity. Clin Obes. 2020.
Peña, A., Olson, M. L., Soltero, E. G., Lee, C., Toledo, M. J., Ayers, S. L., & Shaibi, G. Q. (2020). Evaluating a pragmatic estimate of insulin sensitivity in Latino youth with obesity. Clinical Obesity, doi:10.1111/cob.12353.
Peña A, et al. Evaluating a Pragmatic Estimate of Insulin Sensitivity in Latino Youth With Obesity. Clin Obes. 2020 Jan 21; PubMed PMID: 31962378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluating a pragmatic estimate of insulin sensitivity in Latino youth with obesity. AU - Peña,Armando, AU - Olson,Micah L, AU - Soltero,Erica G, AU - Lee,Chong, AU - Toledo,Meynard J, AU - Ayers,Stephanie L, AU - Shaibi,Gabriel Q, Y1 - 2020/01/21/ PY - 2019/12/10/received PY - 2020/01/03/accepted PY - 2020/1/22/entrez PY - 2020/1/22/pubmed PY - 2020/1/22/medline KW - insulin sensitivity KW - lifestyle intervention KW - measure KW - obesity KW - youth JF - Clinical obesity JO - Clin Obes N2 - The whole-body insulin sensitivity index (WBISI) is a widely used surrogate of insulin sensitivity estimated from glucose and insulin concentrations during an oral glucose tolerance test (OGTT). The original WBISI uses five timepoints but reduced sampling models have been proposed. These reduced models have not been applied to the paediatric population. The purpose of this study is to compare cross-sectional agreement and changes in response to lifestyle intervention between the original WBISI and the WBISI120 using fasting and 2-hour glucose and insulin concentrations from OGTT among Latino adolescents with obesity. We also examined the cost-differential between the two measures. Secondary analyses were conducted with data from Latino adolescents (14-16 years) with obesity (BMI ≥ 95th percentile) who were recruited for a randomized controlled lifestyle intervention trial. Baseline data in youth (n = 148) who underwent a 2-hour OGTT was used to analyse agreement between WBISI and WBISI120 . Data from 65 participants who completed a 12-week lifestyle intervention were used to assess changes and the rate of change between WBISI and WBISI120 . Research costs to determine both measures were compared. WBISI120 showed good cross-sectional agreement (ICCagreement = 0.88) with the full WBISI. Following intervention, WBISI120 increased 62.5% (M ± SD, 1.6 ± 1.2 to 2.6 ± 1.7, P < .001) while WBISI increased by 25.0% (1.6 ± 1.0 to 2.0 ± 1.0, P < .001) but the rate of change for WBISI and WBISI120 was not significantly different (P = .11). WBISI120 costs ~70% less than WBISI. WBISI120 may offer a cost-effective surrogate estimate of insulin sensitivity in Latino youth with obesity. SN - 1758-8111 UR - https://www.unboundmedicine.com/medline/citation/31962378/Evaluating_a_pragmatic_estimate_of_insulin_sensitivity_in_Latino_youth_with_obesity L2 - https://doi.org/10.1111/cob.12353 DB - PRIME DP - Unbound Medicine ER -