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Bariatric surgery-induced weight loss in patients with and without type 2 diabetes mellitus.
Clin Obes. 2020 Jan 21 [Online ahead of print]CO

Abstract

Surgical treatment of obesity leads to weight loss and metabolic improvement, but it is unclear if the response differs between patients with and without type 2 diabetes. Retrospective cohort study comparing weight loss and metabolic outcomes between patients with and without type 2 diabetes, matched for body mass index (BMI), gender and age, 12 months after Roux-en-Y gastric bypass. Forty-eight patients with type 2 diabetes (D) and 48 without type 2 diabetes (ND) were evaluated, 87.5% female, mean age 42.2 ± 0.9 years. The mean baseline weight and BMI of the D and ND groups were, respectively, 120.3 ± 21.6 vs 123.7 ± 20.8 kg (P = .45) and 47.2 ± 7.5 vs 47.2 ± 6.9 kg/m2 (P = .70). After 12 months, there was no significant difference in weight (40.4 ± 16.9 vs 44.1 ± 12.2 kg, P = .28) and BMI (15.8 ± 6.5 vs 16.9 ± 4.5 kg/m2 , P = .26) variation between groups. The parameters that presented significant variation were (D vs ND): fasting blood glucose (41.6 ± 43.0 vs 12.7 ± 17.2 mg/dL, P < .01), HbA1c (1.8 ± 1.6 vs 0.6 ± 0.7%; P < .01), triglycerides (91.1 ± 100.4 vs 54.2 ± 43.8 mg/dL; P = .04), low-density lipoprotein (27.2 ± 41.5 vs 37.5 ± 24.2 mg/dL; P < .01) and gamma glutamyl transferase (46.5 ± 55.3 vs 17.7 ± 11.9 UI/L; P = .04). Weight loss 12 months after a gastric bypass was similar in patients with and without type 2 diabetes, the greater metabolic benefits appearing in patients with type 2 diabetes as they had more pronounced changes at baseline.

Authors+Show Affiliations

Department of Internal Medicine, Federal University of Santa Catarina, Florianópolis, Brazil.Department of Internal Medicine, Federal University of Santa Catarina, Florianópolis, Brazil.Department of Internal Medicine, Federal University of Santa Catarina, Florianópolis, Brazil.Department of Internal Medicine, Federal University of Santa Catarina, Florianópolis, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31962382

Citation

Carvalho, Thatiany A., et al. "Bariatric Surgery-induced Weight Loss in Patients With and Without Type 2 Diabetes Mellitus." Clinical Obesity, 2020, pp. e12356.
Carvalho TA, Ronsoni MF, Hohl A, et al. Bariatric surgery-induced weight loss in patients with and without type 2 diabetes mellitus. Clin Obes. 2020.
Carvalho, T. A., Ronsoni, M. F., Hohl, A., & van de Sande-Lee, S. (2020). Bariatric surgery-induced weight loss in patients with and without type 2 diabetes mellitus. Clinical Obesity, e12356. https://doi.org/10.1111/cob.12356
Carvalho TA, et al. Bariatric Surgery-induced Weight Loss in Patients With and Without Type 2 Diabetes Mellitus. Clin Obes. 2020 Jan 21;e12356. PubMed PMID: 31962382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bariatric surgery-induced weight loss in patients with and without type 2 diabetes mellitus. AU - Carvalho,Thatiany A, AU - Ronsoni,Marcelo F, AU - Hohl,Alexandre, AU - van de Sande-Lee,Simone, Y1 - 2020/01/21/ PY - 2019/10/18/received PY - 2019/12/06/revised PY - 2020/01/03/accepted PY - 2020/1/22/entrez PY - 2020/1/22/pubmed PY - 2020/1/22/medline KW - bariatric surgery KW - obesity KW - type 2 diabetes mellitus KW - weight loss SP - e12356 EP - e12356 JF - Clinical obesity JO - Clin Obes N2 - Surgical treatment of obesity leads to weight loss and metabolic improvement, but it is unclear if the response differs between patients with and without type 2 diabetes. Retrospective cohort study comparing weight loss and metabolic outcomes between patients with and without type 2 diabetes, matched for body mass index (BMI), gender and age, 12 months after Roux-en-Y gastric bypass. Forty-eight patients with type 2 diabetes (D) and 48 without type 2 diabetes (ND) were evaluated, 87.5% female, mean age 42.2 ± 0.9 years. The mean baseline weight and BMI of the D and ND groups were, respectively, 120.3 ± 21.6 vs 123.7 ± 20.8 kg (P = .45) and 47.2 ± 7.5 vs 47.2 ± 6.9 kg/m2 (P = .70). After 12 months, there was no significant difference in weight (40.4 ± 16.9 vs 44.1 ± 12.2 kg, P = .28) and BMI (15.8 ± 6.5 vs 16.9 ± 4.5 kg/m2 , P = .26) variation between groups. The parameters that presented significant variation were (D vs ND): fasting blood glucose (41.6 ± 43.0 vs 12.7 ± 17.2 mg/dL, P < .01), HbA1c (1.8 ± 1.6 vs 0.6 ± 0.7%; P < .01), triglycerides (91.1 ± 100.4 vs 54.2 ± 43.8 mg/dL; P = .04), low-density lipoprotein (27.2 ± 41.5 vs 37.5 ± 24.2 mg/dL; P < .01) and gamma glutamyl transferase (46.5 ± 55.3 vs 17.7 ± 11.9 UI/L; P = .04). Weight loss 12 months after a gastric bypass was similar in patients with and without type 2 diabetes, the greater metabolic benefits appearing in patients with type 2 diabetes as they had more pronounced changes at baseline. SN - 1758-8111 UR - https://www.unboundmedicine.com/medline/citation/31962382/Bariatric_surgery-induced_weight_loss_in_patients_with_and_without_type_2_diabetes_mellitus L2 - https://doi.org/10.1111/cob.12356 DB - PRIME DP - Unbound Medicine ER -
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