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Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging.
Int J Mol Sci. 2020 Jan 19; 21(2)IJ

Abstract

Exosomes are nano-sized membranous vesicles produced by nearly all types of cells. Since exosome-like vesicles are produced in an evolutionarily conserved manner for information and function transfer from the originating cells to recipient cells, an increasing number of studies have focused on their application as therapeutic agents, drug delivery vehicles, and diagnostic targets. Analysis of the in vivo distribution of exosomes is a prerequisite for the development of exosome-based therapeutics and drug delivery vehicles with accurate prediction of therapeutic dose and potential side effects. Various attempts to evaluate the biodistribution of exosomes obtained from different sources have been reported. In this review, we examined the current trends and the advantages and disadvantages of the methods used to determine the biodistribution of exosomes by molecular imaging. We also reviewed 29 publications to compare the methods employed to isolate, analyze, and label exosomes as well as to determine the biodistribution of labeled exosomes.

Authors+Show Affiliations

ExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.ExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.Department of Convergence Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul 05505, Korea. Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.Department of Convergence Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul 05505, Korea. Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.ExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.ExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.ExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.ExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31963931

Citation

Yi, Yong Weon, et al. "Advances in Analysis of Biodistribution of Exosomes By Molecular Imaging." International Journal of Molecular Sciences, vol. 21, no. 2, 2020.
Yi YW, Lee JH, Kim SY, et al. Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging. Int J Mol Sci. 2020;21(2).
Yi, Y. W., Lee, J. H., Kim, S. Y., Pack, C. G., Ha, D. H., Park, S. R., Youn, J., & Cho, B. S. (2020). Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging. International Journal of Molecular Sciences, 21(2). https://doi.org/10.3390/ijms21020665
Yi YW, et al. Advances in Analysis of Biodistribution of Exosomes By Molecular Imaging. Int J Mol Sci. 2020 Jan 19;21(2) PubMed PMID: 31963931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging. AU - Yi,Yong Weon, AU - Lee,Jun Ho, AU - Kim,Sang-Yeob, AU - Pack,Chan-Gi, AU - Ha,Dae Hyun, AU - Park,Sang Rae, AU - Youn,Jinkwon, AU - Cho,Byong Seung, Y1 - 2020/01/19/ PY - 2019/12/20/received PY - 2020/01/15/revised PY - 2020/01/16/accepted PY - 2020/1/23/entrez KW - biodistribution KW - exosomes KW - labeling KW - molecular imaging KW - therapeutics JF - International journal of molecular sciences JO - Int J Mol Sci VL - 21 IS - 2 N2 - Exosomes are nano-sized membranous vesicles produced by nearly all types of cells. Since exosome-like vesicles are produced in an evolutionarily conserved manner for information and function transfer from the originating cells to recipient cells, an increasing number of studies have focused on their application as therapeutic agents, drug delivery vehicles, and diagnostic targets. Analysis of the in vivo distribution of exosomes is a prerequisite for the development of exosome-based therapeutics and drug delivery vehicles with accurate prediction of therapeutic dose and potential side effects. Various attempts to evaluate the biodistribution of exosomes obtained from different sources have been reported. In this review, we examined the current trends and the advantages and disadvantages of the methods used to determine the biodistribution of exosomes by molecular imaging. We also reviewed 29 publications to compare the methods employed to isolate, analyze, and label exosomes as well as to determine the biodistribution of labeled exosomes. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/31963931/Advances_in_Analysis_of_Biodistribution_of_Exosomes_by_Molecular_Imaging L2 - http://www.mdpi.com/resolver?pii=ijms21020665 DB - PRIME DP - Unbound Medicine ER -
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