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IgG4-related lymphadenopathy: a potentially under- and over-diagnosed entity.
Int J Clin Exp Pathol 2017; 10(10):10153-10166IJ

Abstract

IgG4-related lymphadenopathy (IgG4-LAD) is newly described entity, which may occur before, during or after diagnosis of extranodal IgG4-related disease. It is important to recognize IgG4-LAD, especially in cases with lymphadenopathy as the initial presentation, so that the patients can receive prompt treatment. However, it can be challenging to formulate a final diagnosis since IgG4-LAD displays a broad morphologic spectrum. Moreover, morphologic changes alone are not sufficient for diagnosis of IgG4-LAD, and an accurate diagnosis has to take into account of the overall clinical presentations and laboratory studies. Currently, it is not very clear when pathologists should consider workup for potential IgG4-LAD based on the histologic features. Particularly, for some pathologists, it is not certain how to render the diagnosis in reactive lymph nodes with markedly increased IgG4 + cells. In this review, we will attempt to summarize the major clinicopathologic features of IgG4-LAD and its variants, differential diagnoses, and algorithms to establish an accurate diagnosis.

Authors+Show Affiliations

Department of Pathology, University of Colorado Denver/Anschutz Medical Campus Aurora, CO, USA.Department of Pathology and Laboratory Medicine, Indiana University Indianapolis, IN, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31966349

Citation

Pan, Zenggang, and Jiehao Zhou. "IgG4-related Lymphadenopathy: a Potentially Under- and Over-diagnosed Entity." International Journal of Clinical and Experimental Pathology, vol. 10, no. 10, 2017, pp. 10153-10166.
Pan Z, Zhou J. IgG4-related lymphadenopathy: a potentially under- and over-diagnosed entity. Int J Clin Exp Pathol. 2017;10(10):10153-10166.
Pan, Z., & Zhou, J. (2017). IgG4-related lymphadenopathy: a potentially under- and over-diagnosed entity. International Journal of Clinical and Experimental Pathology, 10(10), pp. 10153-10166.
Pan Z, Zhou J. IgG4-related Lymphadenopathy: a Potentially Under- and Over-diagnosed Entity. Int J Clin Exp Pathol. 2017;10(10):10153-10166. PubMed PMID: 31966349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgG4-related lymphadenopathy: a potentially under- and over-diagnosed entity. AU - Pan,Zenggang, AU - Zhou,Jiehao, Y1 - 2017/10/01/ PY - 2016/02/24/received PY - 2016/05/21/accepted PY - 2020/1/23/entrez PY - 2017/10/1/pubmed PY - 2017/10/1/medline KW - IgG4 KW - IgG4-related disease KW - IgG4-related lymphadenopathy SP - 10153 EP - 10166 JF - International journal of clinical and experimental pathology JO - Int J Clin Exp Pathol VL - 10 IS - 10 N2 - IgG4-related lymphadenopathy (IgG4-LAD) is newly described entity, which may occur before, during or after diagnosis of extranodal IgG4-related disease. It is important to recognize IgG4-LAD, especially in cases with lymphadenopathy as the initial presentation, so that the patients can receive prompt treatment. However, it can be challenging to formulate a final diagnosis since IgG4-LAD displays a broad morphologic spectrum. Moreover, morphologic changes alone are not sufficient for diagnosis of IgG4-LAD, and an accurate diagnosis has to take into account of the overall clinical presentations and laboratory studies. Currently, it is not very clear when pathologists should consider workup for potential IgG4-LAD based on the histologic features. Particularly, for some pathologists, it is not certain how to render the diagnosis in reactive lymph nodes with markedly increased IgG4 + cells. In this review, we will attempt to summarize the major clinicopathologic features of IgG4-LAD and its variants, differential diagnoses, and algorithms to establish an accurate diagnosis. SN - 1936-2625 UR - https://www.unboundmedicine.com/medline/citation/31966349/IgG4-related_lymphadenopathy:_a_potentially_under-_and_over-diagnosed_entity L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31966349/ DB - PRIME DP - Unbound Medicine ER -