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Circulating miR-330-3p in Late Pregnancy is Associated with Pregnancy Outcomes Among Lean Women with GDM.
Sci Rep. 2020 Jan 22; 10(1):908.SR

Abstract

Gestational Diabetes Mellitus (GDM) is characterised by insulin resistance accompanied by reduced beta-cell compensation to increased insulin demand, typically observed in the second and third trimester and associated with adverse pregnancy outcomes. There is a need for a biomarker that can accurately monitor status and predict outcome in GDM, reducing foetal-maternal morbidity and mortality risks. To this end, circulating microRNAs (miRNAs) present themselves as promising candidates, stably expressed in serum and known to play crucial roles in regulation of glucose metabolism. We analysed circulating miRNA profiles in a cohort of GDM patients (n = 31) and nondiabetic controls (n = 29) during the third trimester for miRNA associated with insulin-secretory defects and glucose homeostasis. We identified miR-330-3p as being significantly upregulated in lean women with GDM compared to nondiabetic controls. Furthermore, increased levels of miR-330-3p were associated with better response to treatment (diet vs. insulin), with lower levels associated with exogenous insulin requirement. We observed miR-330-3p to be significantly related to the percentage of caesarean deliveries, with miR-330-3p expression significantly higher in spontaneously delivered GDM patients. We report this strong novel association of circulating miR-330-3p with risk of primary caesarean delivery as a pregnancy outcome linked with poor maternal glycaemic control, strengthening the growing body of evidence for roles of diabetes-associated miRNAs in glucose homeostasis and adaptation to the complex changes related to pregnancy.

Authors+Show Affiliations

Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, 2, Ireland.Servicio de Endocrinología y Nutrición, Hospital Universitario Puerta del Mar, Cádiz, Spain.Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, 2, Ireland.Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, 2, Ireland.Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, 2, Ireland.Servicio de Endocrinología y Nutrición, Hospital Universitario Puerta del Mar, Cádiz, Spain.Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, 2, Ireland. Department of Endocrinology, Mater Misericordiae University Hospital, Eccles Street, Dublin, 7, Ireland.Servicio de Endocrinología y Nutrición, Hospital Universitario Puerta del Mar, Cádiz, Spain. cristina.tinoco@uca.es.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31969632

Citation

Pfeiffer, Shona, et al. "Circulating miR-330-3p in Late Pregnancy Is Associated With Pregnancy Outcomes Among Lean Women With GDM." Scientific Reports, vol. 10, no. 1, 2020, p. 908.
Pfeiffer S, Sánchez-Lechuga B, Donovan P, et al. Circulating miR-330-3p in Late Pregnancy is Associated with Pregnancy Outcomes Among Lean Women with GDM. Sci Rep. 2020;10(1):908.
Pfeiffer, S., Sánchez-Lechuga, B., Donovan, P., Halang, L., Prehn, J. H. M., Campos-Caro, A., Byrne, M. M., & López-Tinoco, C. (2020). Circulating miR-330-3p in Late Pregnancy is Associated with Pregnancy Outcomes Among Lean Women with GDM. Scientific Reports, 10(1), 908. https://doi.org/10.1038/s41598-020-57838-6
Pfeiffer S, et al. Circulating miR-330-3p in Late Pregnancy Is Associated With Pregnancy Outcomes Among Lean Women With GDM. Sci Rep. 2020 Jan 22;10(1):908. PubMed PMID: 31969632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating miR-330-3p in Late Pregnancy is Associated with Pregnancy Outcomes Among Lean Women with GDM. AU - Pfeiffer,Shona, AU - Sánchez-Lechuga,Begoña, AU - Donovan,Paul, AU - Halang,Luise, AU - Prehn,Jochen H M, AU - Campos-Caro,Antonio, AU - Byrne,Maria M, AU - López-Tinoco,Cristina, Y1 - 2020/01/22/ PY - 2019/06/07/received PY - 2019/12/30/accepted PY - 2020/1/24/entrez PY - 2020/1/24/pubmed PY - 2020/1/24/medline SP - 908 EP - 908 JF - Scientific reports JO - Sci Rep VL - 10 IS - 1 N2 - Gestational Diabetes Mellitus (GDM) is characterised by insulin resistance accompanied by reduced beta-cell compensation to increased insulin demand, typically observed in the second and third trimester and associated with adverse pregnancy outcomes. There is a need for a biomarker that can accurately monitor status and predict outcome in GDM, reducing foetal-maternal morbidity and mortality risks. To this end, circulating microRNAs (miRNAs) present themselves as promising candidates, stably expressed in serum and known to play crucial roles in regulation of glucose metabolism. We analysed circulating miRNA profiles in a cohort of GDM patients (n = 31) and nondiabetic controls (n = 29) during the third trimester for miRNA associated with insulin-secretory defects and glucose homeostasis. We identified miR-330-3p as being significantly upregulated in lean women with GDM compared to nondiabetic controls. Furthermore, increased levels of miR-330-3p were associated with better response to treatment (diet vs. insulin), with lower levels associated with exogenous insulin requirement. We observed miR-330-3p to be significantly related to the percentage of caesarean deliveries, with miR-330-3p expression significantly higher in spontaneously delivered GDM patients. We report this strong novel association of circulating miR-330-3p with risk of primary caesarean delivery as a pregnancy outcome linked with poor maternal glycaemic control, strengthening the growing body of evidence for roles of diabetes-associated miRNAs in glucose homeostasis and adaptation to the complex changes related to pregnancy. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/31969632/Circulating_miR-330-3p_in_Late_Pregnancy_is_Associated_with_Pregnancy_Outcomes_Among_Lean_Women_with_GDM L2 - http://dx.doi.org/10.1038/s41598-020-57838-6 DB - PRIME DP - Unbound Medicine ER -
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