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Frozen embryo transfer: Endometrial preparation by letrozole versus hormone replacement cycle: A randomized clinical trial.
Int J Reprod Biomed (Yazd) 2019; 17(12):915-922IJ

Abstract

Background

The endometrial preparation with stimulating natural cycles for frozen embryo transfer (FET) have benefits like lower cost and ease of use.

Objective

Comparing the clinical outcome of letrozole versus hormone replacement (HR) for endometrial preparation in women with normal menstrual cycles for FET in artificial reproduction techniques.

Materials and Methods

A total of 167 participants who had frozen embryos and regular ovulatory cycles were randomly divided into two groups for endometrial preparation. One group (82 women) was stimulated with letrozole 5mg/day and the other group (85 women) was hormonally stimulated by oral estradiol valerate (2 mg three times a day). All participants were followed serially by ultrasonography. Any patient who did not reach optimal endometrial thickness was excluded from the study. Implantation, biochemical and clinical pregnancy and abortion rate were reported.

Results

There was no significant difference in the mean age, duration, and primary or secondary infertility, cause of the infertility, number, and quality of transferred embryos between the groups. The mean estradiol level on the day of transfer was 643 ± 217 in the HR group and 547 ± 212 in the letrozole group (P = 0.01), which was significantly different. The clinical pregnancy rate was 38.7 in the letrozole group, higher than the HR group (25.3) but not significantly different (P = 0.06).

Conclusion

For endometrial preparation in women with a normal cycle, letrozole yields higher pregnancy rate although it is not significant; due to its cost, ease in use, and lower side effects, letrozole is a good choice.

Authors+Show Affiliations

Infertility Research Center, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Infertility Research Center, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Infertility Research Center, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Infertility Research Center, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Infertility Research Center, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31970313

Citation

Samsami, Alamtaj, et al. "Frozen Embryo Transfer: Endometrial Preparation By Letrozole Versus Hormone Replacement Cycle: a Randomized Clinical Trial." International Journal of Reproductive Biomedicine (Yazd, Iran), vol. 17, no. 12, 2019, pp. 915-922.
Samsami A, Ghasmpour L, Davoodi S, et al. Frozen embryo transfer: Endometrial preparation by letrozole versus hormone replacement cycle: A randomized clinical trial. Int J Reprod Biomed (Yazd). 2019;17(12):915-922.
Samsami, A., Ghasmpour, L., Davoodi, S., Moradi Alamdarloo, S., Rahmati, J., Karimian, A., & Homayoon, H. (2019). Frozen embryo transfer: Endometrial preparation by letrozole versus hormone replacement cycle: A randomized clinical trial. International Journal of Reproductive Biomedicine (Yazd, Iran), 17(12), pp. 915-922. doi:10.18502/ijrm.v17i12.5793.
Samsami A, et al. Frozen Embryo Transfer: Endometrial Preparation By Letrozole Versus Hormone Replacement Cycle: a Randomized Clinical Trial. Int J Reprod Biomed (Yazd). 2019;17(12):915-922. PubMed PMID: 31970313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frozen embryo transfer: Endometrial preparation by letrozole versus hormone replacement cycle: A randomized clinical trial. AU - Samsami,Alamtaj, AU - Ghasmpour,Leila, AU - Davoodi,Sara, AU - Moradi Alamdarloo,Shaghayegh, AU - Rahmati,Jamshid, AU - Karimian,Ali, AU - Homayoon,Hamide, Y1 - 2019/12/30/ PY - 2019/06/23/received PY - 2019/07/29/revised PY - 2019/08/10/accepted PY - 2020/1/24/entrez PY - 2020/1/24/pubmed PY - 2020/1/24/medline KW - Embryo. KW - Endometrial KW - Frozen KW - Hormone replacement KW - Preparation KW - Letrozole SP - 915 EP - 922 JF - International journal of reproductive biomedicine (Yazd, Iran) JO - Int J Reprod Biomed (Yazd) VL - 17 IS - 12 N2 - Background: The endometrial preparation with stimulating natural cycles for frozen embryo transfer (FET) have benefits like lower cost and ease of use. Objective: Comparing the clinical outcome of letrozole versus hormone replacement (HR) for endometrial preparation in women with normal menstrual cycles for FET in artificial reproduction techniques. Materials and Methods: A total of 167 participants who had frozen embryos and regular ovulatory cycles were randomly divided into two groups for endometrial preparation. One group (82 women) was stimulated with letrozole 5mg/day and the other group (85 women) was hormonally stimulated by oral estradiol valerate (2 mg three times a day). All participants were followed serially by ultrasonography. Any patient who did not reach optimal endometrial thickness was excluded from the study. Implantation, biochemical and clinical pregnancy and abortion rate were reported. Results: There was no significant difference in the mean age, duration, and primary or secondary infertility, cause of the infertility, number, and quality of transferred embryos between the groups. The mean estradiol level on the day of transfer was 643 ± 217 in the HR group and 547 ± 212 in the letrozole group (P = 0.01), which was significantly different. The clinical pregnancy rate was 38.7 in the letrozole group, higher than the HR group (25.3) but not significantly different (P = 0.06). Conclusion: For endometrial preparation in women with a normal cycle, letrozole yields higher pregnancy rate although it is not significant; due to its cost, ease in use, and lower side effects, letrozole is a good choice. SN - 2476-4108 UR - https://www.unboundmedicine.com/medline/citation/31970313/Frozen_embryo_transfer:_Endometrial_preparation_by_letrozole_versus_hormone_replacement_cycle:_A_randomized_clinical_trial L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31970313/ DB - PRIME DP - Unbound Medicine ER -