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The incidence rate of unresponsive thin endometrium in frozen embryo transfer cycles: A case-series of therapy with granulocyte colony stimulating factor.
Int J Reprod Biomed (Yazd). 2019 Dec; 17(12):923-928.IJ

Abstract

Background

Treatment-resistant thin endometrium (TTE) during in-vitro fertilization is a relatively uncommon and challenging problem.

Objective

The primary aim of the study was to assess the TTE rate during frozen embryo transfer (FET) cycles and the secondary aim was to evaluate the effect of intrauterine instillation of granulocyte colony stimulating factor (G-CSF) in these cases.

Materials and Methods

In this cross-sectional study, all of the women who underwent FET cycles with hormonal endometrial preparation in Royan Institute from June 2015 to March 2018 were evaluated and all of the cases with TTE diagnosis (endometrial thickness < 7 mm after using high doses of estradiol) were included. In the eligible cases, 300 μgr of G-CSF was infused intrauterine. If the endometrium had not reached at least a 7-mm, a second infusion was prescribed within 48 hr later.

Results

During the study, 8,363 of FET cycles were evaluated and a total of 30 infertile patients (0.35%) with TTE diagnosis were detected. Finally, 20 eligible patients were included. The changes of endometrial thickness after G-CSF therapy were significant (p < 0.001); however, the endometrial thickness did not reach 7 mm in nine patients (45%) and the embryo transfer was canceled.

Conclusion

It was found that the rate of TTE during the FET cycle is very low and intrauterine perfusion of G-CSF has a potential effect to increase the endometrial thickness in these patients; however, the rate of cancellation was still high and poor pregnancy outcomes were observed.

Authors+Show Affiliations

Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Department of Obstetrics and Gynecology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran. Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Science (IUMS), Tehran, Iran.Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31970314

Citation

Miralaei, Shokouhosadat, et al. "The Incidence Rate of Unresponsive Thin Endometrium in Frozen Embryo Transfer Cycles: a Case-series of Therapy With Granulocyte Colony Stimulating Factor." International Journal of Reproductive Biomedicine (Yazd, Iran), vol. 17, no. 12, 2019, pp. 923-928.
Miralaei S, Ashrafi M, Arabipoor A, et al. The incidence rate of unresponsive thin endometrium in frozen embryo transfer cycles: A case-series of therapy with granulocyte colony stimulating factor. Int J Reprod Biomed (Yazd). 2019;17(12):923-928.
Miralaei, S., Ashrafi, M., Arabipoor, A., Zolfaghari, Z., & Taghvaei, S. (2019). The incidence rate of unresponsive thin endometrium in frozen embryo transfer cycles: A case-series of therapy with granulocyte colony stimulating factor. International Journal of Reproductive Biomedicine (Yazd, Iran), 17(12), 923-928. https://doi.org/10.18502/ijrm.v17i12.5797
Miralaei S, et al. The Incidence Rate of Unresponsive Thin Endometrium in Frozen Embryo Transfer Cycles: a Case-series of Therapy With Granulocyte Colony Stimulating Factor. Int J Reprod Biomed (Yazd). 2019;17(12):923-928. PubMed PMID: 31970314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The incidence rate of unresponsive thin endometrium in frozen embryo transfer cycles: A case-series of therapy with granulocyte colony stimulating factor. AU - Miralaei,Shokouhosadat, AU - Ashrafi,Mahnaz, AU - Arabipoor,Arezoo, AU - Zolfaghari,Zahra, AU - Taghvaei,Saeideh, Y1 - 2019/12/30/ PY - 2019/01/13/received PY - 2019/06/03/revised PY - 2019/08/14/accepted PY - 2020/1/24/entrez PY - 2020/1/24/pubmed PY - 2020/1/24/medline KW - Cryopreservation KW - Embryo transfer KW - Endometrial diseases. KW - Granulocyte colony-stimulating factor SP - 923 EP - 928 JF - International journal of reproductive biomedicine (Yazd, Iran) JO - Int J Reprod Biomed (Yazd) VL - 17 IS - 12 N2 - Background: Treatment-resistant thin endometrium (TTE) during in-vitro fertilization is a relatively uncommon and challenging problem. Objective: The primary aim of the study was to assess the TTE rate during frozen embryo transfer (FET) cycles and the secondary aim was to evaluate the effect of intrauterine instillation of granulocyte colony stimulating factor (G-CSF) in these cases. Materials and Methods: In this cross-sectional study, all of the women who underwent FET cycles with hormonal endometrial preparation in Royan Institute from June 2015 to March 2018 were evaluated and all of the cases with TTE diagnosis (endometrial thickness < 7 mm after using high doses of estradiol) were included. In the eligible cases, 300 μgr of G-CSF was infused intrauterine. If the endometrium had not reached at least a 7-mm, a second infusion was prescribed within 48 hr later. Results: During the study, 8,363 of FET cycles were evaluated and a total of 30 infertile patients (0.35%) with TTE diagnosis were detected. Finally, 20 eligible patients were included. The changes of endometrial thickness after G-CSF therapy were significant (p < 0.001); however, the endometrial thickness did not reach 7 mm in nine patients (45%) and the embryo transfer was canceled. Conclusion: It was found that the rate of TTE during the FET cycle is very low and intrauterine perfusion of G-CSF has a potential effect to increase the endometrial thickness in these patients; however, the rate of cancellation was still high and poor pregnancy outcomes were observed. SN - 2476-4108 UR - https://www.unboundmedicine.com/medline/citation/31970314/The_incidence_rate_of_unresponsive_thin_endometrium_in_frozen_embryo_transfer_cycles:_A_case-series_of_therapy_with_granulocyte_colony_stimulating_factor L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31970314/ DB - PRIME DP - Unbound Medicine ER -
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