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Copper oxychloride-induced testicular damage of adult albino rats and the possible role of curcumin in healing the damage.

Abstract

The current research study investigated the effect of 80 mg/kg b.wt./day curcumin (cur) against 50, 100, and 200 mg/kg copper oxychloride (COC) for 90 days induced testicular damage using histological, ultrastructural, and biochemical techniques. Histological and cellular abnormalities have been noted in seminiferous tubules of COC-treated group and treated group with Cur- and COC-treated group. The biochemical result showed that serum testosterone was significantly decreased in COC-treated rats and Cur COC-treated rats compared with the control groups. Testes copper content and malondialdehyde was increased, whereas the testes total antioxidant, manganese, ferrous, and zinc levels were decreased (p ≥ 0.05) compared to the control groups. In conclusion, the present work reported that the treatment of rats with 80 mg/kg body weight curcumin prior to treatment with COC did not mitigate the deleterious effects of COC and manifested no signs of protection.

Authors+Show Affiliations

Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt. heba_nageh@hotmail.com.Zoology Department, Faculty of Science, Suez University, Suez, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31970636

Citation

Gad El-Hak, Heba Nageh, and Yomn Mohammed Mobarak. "Copper Oxychloride-induced Testicular Damage of Adult Albino Rats and the Possible Role of Curcumin in Healing the Damage." Environmental Science and Pollution Research International, 2020.
Gad El-Hak HN, Mobarak YM. Copper oxychloride-induced testicular damage of adult albino rats and the possible role of curcumin in healing the damage. Environ Sci Pollut Res Int. 2020.
Gad El-Hak, H. N., & Mobarak, Y. M. (2020). Copper oxychloride-induced testicular damage of adult albino rats and the possible role of curcumin in healing the damage. Environmental Science and Pollution Research International, doi:10.1007/s11356-020-07715-6.
Gad El-Hak HN, Mobarak YM. Copper Oxychloride-induced Testicular Damage of Adult Albino Rats and the Possible Role of Curcumin in Healing the Damage. Environ Sci Pollut Res Int. 2020 Jan 22; PubMed PMID: 31970636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Copper oxychloride-induced testicular damage of adult albino rats and the possible role of curcumin in healing the damage. AU - Gad El-Hak,Heba Nageh, AU - Mobarak,Yomn Mohammed, Y1 - 2020/01/22/ PY - 2019/09/24/received PY - 2020/01/10/accepted PY - 2020/1/24/entrez KW - Copper oxychloride KW - Curcumin KW - Infertility KW - Sex hormones KW - Testes KW - Testes trace element JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int N2 - The current research study investigated the effect of 80 mg/kg b.wt./day curcumin (cur) against 50, 100, and 200 mg/kg copper oxychloride (COC) for 90 days induced testicular damage using histological, ultrastructural, and biochemical techniques. Histological and cellular abnormalities have been noted in seminiferous tubules of COC-treated group and treated group with Cur- and COC-treated group. The biochemical result showed that serum testosterone was significantly decreased in COC-treated rats and Cur COC-treated rats compared with the control groups. Testes copper content and malondialdehyde was increased, whereas the testes total antioxidant, manganese, ferrous, and zinc levels were decreased (p ≥ 0.05) compared to the control groups. In conclusion, the present work reported that the treatment of rats with 80 mg/kg body weight curcumin prior to treatment with COC did not mitigate the deleterious effects of COC and manifested no signs of protection. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/31970636/Copper_oxychloride-induced_testicular_damage_of_adult_albino_rats_and_the_possible_role_of_curcumin_in_healing_the_damage L2 - https://dx.doi.org/10.1007/s11356-020-07715-6 DB - PRIME DP - Unbound Medicine ER -