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Limited view cone-beam x-ray luminescence tomography based on depth compensation and group sparsity prior.
J Biomed Opt 2020; 25(1):1-14JB

Abstract

Significance: As a promising hybrid imaging technique with x-ray excitable nanophosphors, cone-beam x-ray luminescence computed tomography (CB-XLCT) has been proposed for in-depth biological imaging applications. In situations in which the full rotation of the imaging object (or x-ray source) is inapplicable, the x-ray excitation is limited by geometry, or a lower x-ray excitation dose is mandatory, limited view CB-XLCT reconstruction would be essential. However, this will result in severe ill-posedness and poor image quality. <p>

Aim:

The aim is to develop a limited view CB-XLCT imaging strategy to reduce the scanning span and a corresponding reconstruction method to achieve robust imaging performance.</p> <p> Approach: In this study, a group sparsity-based reconstruction method is proposed with the consideration that nanophosphors usually cluster in certain regions, such as tumors or major organs such as the liver. In addition, depth compensation (DC) is adopted to avoid the depth inconsistency caused by a limited view strategy. </p> <p>

Results:

Experiments using numerical simulations and physical phantoms with different edge-to-edge distances were carried out to illustrate the validity of the proposed method. The reconstruction results showed that the proposed method outperforms conventional methods in terms of localization accuracy, target shape, image contrast, and spatial resolution with two perpendicular projections. </p> <p>

Conclusions:

A limited view CB-XLCT imaging strategy with two perpendicular projections and a reconstruction method based on DC and group sparsity, which is essential for fast CB-XLCT imaging and for some practical imaging applications, such as imaging-guided surgery, is proposed. </p>

Authors+Show Affiliations

Fourth Military Medical University, Department of Biomedical Engineering, Xi'an, Shaanxi, China.Fourth Military Medical University, Department of Biomedical Engineering, Xi'an, Shaanxi, China.Fourth Military Medical University, Department of Biomedical Engineering, Xi'an, Shaanxi, China.Fourth Military Medical University, Department of Biomedical Engineering, Xi'an, Shaanxi, China.Fourth Military Medical University, Department of Biomedical Engineering, Xi'an, Shaanxi, China.Northwest Institute of Nuclear Technology, Xi'an, Shaanxi, China.Fourth Military Medical University, Department of Biomedical Engineering, Xi'an, Shaanxi, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31970943

Citation

Gao, Peng, et al. "Limited View Cone-beam X-ray Luminescence Tomography Based On Depth Compensation and Group Sparsity Prior." Journal of Biomedical Optics, vol. 25, no. 1, 2020, pp. 1-14.
Gao P, Rong J, Liu T, et al. Limited view cone-beam x-ray luminescence tomography based on depth compensation and group sparsity prior. J Biomed Opt. 2020;25(1):1-14.
Gao, P., Rong, J., Liu, T., Zhang, W., Lan, B., Ouyang, X., & Lu, H. (2020). Limited view cone-beam x-ray luminescence tomography based on depth compensation and group sparsity prior. Journal of Biomedical Optics, 25(1), pp. 1-14. doi:10.1117/1.JBO.25.1.016004.
Gao P, et al. Limited View Cone-beam X-ray Luminescence Tomography Based On Depth Compensation and Group Sparsity Prior. J Biomed Opt. 2020;25(1):1-14. PubMed PMID: 31970943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Limited view cone-beam x-ray luminescence tomography based on depth compensation and group sparsity prior. AU - Gao,Peng, AU - Rong,Junyan, AU - Liu,Tianshuai, AU - Zhang,Wenli, AU - Lan,Bin, AU - Ouyang,Xiaoping, AU - Lu,Hongbing, PY - 2019/11/08/received PY - 2020/01/06/accepted PY - 2020/1/24/entrez PY - 2020/1/24/pubmed PY - 2020/1/24/medline KW - depth compensation KW - group sparsity KW - ill-posed KW - limited view KW - x-ray luminescence SP - 1 EP - 14 JF - Journal of biomedical optics JO - J Biomed Opt VL - 25 IS - 1 N2 - Significance: As a promising hybrid imaging technique with x-ray excitable nanophosphors, cone-beam x-ray luminescence computed tomography (CB-XLCT) has been proposed for in-depth biological imaging applications. In situations in which the full rotation of the imaging object (or x-ray source) is inapplicable, the x-ray excitation is limited by geometry, or a lower x-ray excitation dose is mandatory, limited view CB-XLCT reconstruction would be essential. However, this will result in severe ill-posedness and poor image quality. <p> Aim: The aim is to develop a limited view CB-XLCT imaging strategy to reduce the scanning span and a corresponding reconstruction method to achieve robust imaging performance.</p> <p> Approach: In this study, a group sparsity-based reconstruction method is proposed with the consideration that nanophosphors usually cluster in certain regions, such as tumors or major organs such as the liver. In addition, depth compensation (DC) is adopted to avoid the depth inconsistency caused by a limited view strategy. </p> <p> Results: Experiments using numerical simulations and physical phantoms with different edge-to-edge distances were carried out to illustrate the validity of the proposed method. The reconstruction results showed that the proposed method outperforms conventional methods in terms of localization accuracy, target shape, image contrast, and spatial resolution with two perpendicular projections. </p> <p> Conclusions: A limited view CB-XLCT imaging strategy with two perpendicular projections and a reconstruction method based on DC and group sparsity, which is essential for fast CB-XLCT imaging and for some practical imaging applications, such as imaging-guided surgery, is proposed. </p> SN - 1560-2281 UR - https://www.unboundmedicine.com/medline/citation/31970943/Limited_view_cone-beam_x-ray_luminescence_tomography_based_on_depth_compensation_and_group_sparsity_prior L2 - https://doi.org/10.1117/1.JBO.25.1.016004 DB - PRIME DP - Unbound Medicine ER -