Tags

Type your tag names separated by a space and hit enter

The crystal structure of a natural DNA polymerase complexed with mirror DNA.

Abstract

The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered. The binding affinity of Dpo4 polymerase for l-DNA was comparable to that for d-DNA. The crystal structure of Dpo4/l-DNA complex revealed a dimer formed by the little finger domain that provides a binding site for l-DNA.

Authors+Show Affiliations

Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea. drahn@kist.re.kr and Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology (UST), Seoul 02792, Republic of Korea.Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea. drahn@kist.re.kr.Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea. drahn@kist.re.kr.Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea. drahn@kist.re.kr.Rigaku Americas Corporation, 9009 New Trails Drive, The Woodlands, TX, USA.Department of Pharmacy, Dongguk University-Seoul, 32 Dongguk-ro, Ilsandong-gu, Goyang, Gyeonggi 13024, Republic of Korea.Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea. drahn@kist.re.kr.Department of Pharmacy, Dongguk University-Seoul, 32 Dongguk-ro, Ilsandong-gu, Goyang, Gyeonggi 13024, Republic of Korea.Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea. drahn@kist.re.kr and Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology (UST), Seoul 02792, Republic of Korea.Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea. drahn@kist.re.kr and Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology (UST), Seoul 02792, Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31971182

Citation

An, Jinsu, et al. "The Crystal Structure of a Natural DNA Polymerase Complexed With Mirror DNA." Chemical Communications (Cambridge, England), 2020.
An J, Choi J, Hwang D, et al. The crystal structure of a natural DNA polymerase complexed with mirror DNA. Chem Commun (Camb). 2020.
An, J., Choi, J., Hwang, D., Park, J., Pemble, C. W., Duong, T. H. M., ... Ahn, D. R. (2020). The crystal structure of a natural DNA polymerase complexed with mirror DNA. Chemical Communications (Cambridge, England), doi:10.1039/c9cc09351f.
An J, et al. The Crystal Structure of a Natural DNA Polymerase Complexed With Mirror DNA. Chem Commun (Camb). 2020 Jan 23; PubMed PMID: 31971182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The crystal structure of a natural DNA polymerase complexed with mirror DNA. AU - An,Jinsu, AU - Choi,Jaewoo, AU - Hwang,Dohyeon, AU - Park,Jihyun, AU - Pemble,Charles W,4th AU - Duong,Thi Hoai Men, AU - Kim,Kyoung-Ran, AU - Ahn,Heechul, AU - Chung,Hak Suk, AU - Ahn,Dae-Ro, Y1 - 2020/01/23/ PY - 2020/1/24/entrez JF - Chemical communications (Cambridge, England) JO - Chem. Commun. (Camb.) N2 - The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered. The binding affinity of Dpo4 polymerase for l-DNA was comparable to that for d-DNA. The crystal structure of Dpo4/l-DNA complex revealed a dimer formed by the little finger domain that provides a binding site for l-DNA. SN - 1364-548X UR - https://www.unboundmedicine.com/medline/citation/31971182/The_crystal_structure_of_a_natural_DNA_polymerase_complexed_with_mirror_DNA L2 - https://doi.org/10.1039/c9cc09351f DB - PRIME DP - Unbound Medicine ER -