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IGF-1 IS AN INDEPENDENT PREDICTOR OF RETINAL ARTERIES REMODELING IN SUBJECTS WITH UNCONTROLLED ACROMEGALY.

Abstract

CONTEXT

Cardiovascular disease is one of the main causes of morbidity in active acromegaly due to the increased prevalence of risk factors and arterial consequences of increased growth hormone levels. No in vivo study has evaluated the consequences of acromegaly on the retinal microvasculature.

OBJECTIVE

The aim of this study was to identify in vivo the presence of morphological alterations of retinal arterioles in subjects with acromegaly.

PATIENTS AND METHODS

Single-center retrospective study of a cohort of 60 subjects with acromegaly, matched to 60 controls, who were referred for Adaptive Optics Camera (AOC) from September 2014 to December 2016. Among subjects with acromegaly 19 had an Active Disease (AD) and 41 a controlled disease (CD) according to IGF-1 ratio (IGF-1r). Retinal arteriolar remodeling was previously assessed using Adaptive Optics Camera (AOC) in order to measure wall to lumen ratio (WLR), wall thickness (WT), internal diameter (ID) and wall cross sectional area (WCSA).

RESULTS

WLR was significantly higher in AD subjects compared to CD subjects and Controls (AD: 0.311±0.06, CD: 0.279±0.04, Controls: 0.281±0.04, p=0.031). A significant positive correlation was observed between WLR and IGF-1r (R2=0.215, p<0.001), even after adjustment for gender, age, Systolic Blood Pressure (SBP) and the presence of dopamine agonist treatment (R2=0.406, p<0.001). Retinal arteriolar anatomical indices were comparable between CD and controls.

CONCLUSION

Active acromegaly is associated with the presence of small retinal arteriolar remodeling. These results provide new perspectives to better stratify cardiovascular risk and consequently optimize treatment in acromegaly.

Authors+Show Affiliations

A Gallo, Endocrinology and Cardiovascular Prevention, University Hospital Pitié Salpêtrière, Paris, 75651, France.E Chaigneau, Endocrinologie et Métabolisme, Hopital Universitaire Pitie Salpetriere, Paris, 75651, France.C Jublanc, Endocrinologie, Hôpital de la Pitié-Salpêtrière, Assistance publique des Hôpitaux de Paris, Paris, France.D Rosenbaum, Endocrinology and Cardiovascular Prevention, University Hospital Pitié Salpêtrière, Paris, France.A Mattina, Internal Medicine and Medical Specialties, University of Palermo School of Medicine and Surgery, Palermo, Italy.M Paques, Clinical Investigation Center, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France.F Rossant, Institut Supérieur d'Electronique, Institut Supérieur d'Electronique, Paris, France.X Girerd, Endocrinology and Cardiovascular Prevention, University Hospital Pitié Salpêtrière, Paris, France.M Leban, Laboratory of endocrine biochemistry - Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, 75015, France.E Bruckert, Endocrinology and Cardiovascular Prevention, University Hospital Pitié Salpêtrière, Paris, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31972545

Citation

Gallo, Antonio, et al. "IGF-1 IS an INDEPENDENT PREDICTOR of RETINAL ARTERIES REMODELING in SUBJECTS WITH UNCONTROLLED ACROMEGALY." European Journal of Endocrinology, 2020.
Gallo A, Chaigneau E, Jublanc C, et al. IGF-1 IS AN INDEPENDENT PREDICTOR OF RETINAL ARTERIES REMODELING IN SUBJECTS WITH UNCONTROLLED ACROMEGALY. Eur J Endocrinol. 2020.
Gallo, A., Chaigneau, E., Jublanc, C., Rosenbaum, D., Mattina, A., Paques, M., ... Bruckert, E. (2020). IGF-1 IS AN INDEPENDENT PREDICTOR OF RETINAL ARTERIES REMODELING IN SUBJECTS WITH UNCONTROLLED ACROMEGALY. European Journal of Endocrinology, doi:10.1530/EJE-19-0390.
Gallo A, et al. IGF-1 IS an INDEPENDENT PREDICTOR of RETINAL ARTERIES REMODELING in SUBJECTS WITH UNCONTROLLED ACROMEGALY. Eur J Endocrinol. 2020 Jan 1; PubMed PMID: 31972545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IGF-1 IS AN INDEPENDENT PREDICTOR OF RETINAL ARTERIES REMODELING IN SUBJECTS WITH UNCONTROLLED ACROMEGALY. AU - Gallo,Antonio, AU - Chaigneau,Emmanuelle, AU - Jublanc,Christel, AU - Rosenbaum,David, AU - Mattina,Alessandro, AU - Paques,Michel, AU - Rossant,Florence, AU - Girerd,Xavier, AU - Leban,Monique, AU - Bruckert,Eric, Y1 - 2020/01/01/ PY - 2019/09/19/received PY - 2020/01/23/accepted PY - 2020/1/24/entrez PY - 2020/1/24/pubmed PY - 2020/1/24/medline JF - European journal of endocrinology JO - Eur. J. Endocrinol. N2 - CONTEXT: Cardiovascular disease is one of the main causes of morbidity in active acromegaly due to the increased prevalence of risk factors and arterial consequences of increased growth hormone levels. No in vivo study has evaluated the consequences of acromegaly on the retinal microvasculature. OBJECTIVE: The aim of this study was to identify in vivo the presence of morphological alterations of retinal arterioles in subjects with acromegaly. PATIENTS AND METHODS: Single-center retrospective study of a cohort of 60 subjects with acromegaly, matched to 60 controls, who were referred for Adaptive Optics Camera (AOC) from September 2014 to December 2016. Among subjects with acromegaly 19 had an Active Disease (AD) and 41 a controlled disease (CD) according to IGF-1 ratio (IGF-1r). Retinal arteriolar remodeling was previously assessed using Adaptive Optics Camera (AOC) in order to measure wall to lumen ratio (WLR), wall thickness (WT), internal diameter (ID) and wall cross sectional area (WCSA). RESULTS: WLR was significantly higher in AD subjects compared to CD subjects and Controls (AD: 0.311±0.06, CD: 0.279±0.04, Controls: 0.281±0.04, p=0.031). A significant positive correlation was observed between WLR and IGF-1r (R2=0.215, p<0.001), even after adjustment for gender, age, Systolic Blood Pressure (SBP) and the presence of dopamine agonist treatment (R2=0.406, p<0.001). Retinal arteriolar anatomical indices were comparable between CD and controls. CONCLUSION: Active acromegaly is associated with the presence of small retinal arteriolar remodeling. These results provide new perspectives to better stratify cardiovascular risk and consequently optimize treatment in acromegaly. SN - 1479-683X UR - https://www.unboundmedicine.com/medline/citation/31972545/IGF-1_IS_AN_INDEPENDENT_PREDICTOR_OF_RETINAL_ARTERIES_REMODELING_IN_SUBJECTS_WITH_UNCONTROLLED_ACROMEGALY L2 - https://eje.bioscientifica.com/doi/10.1530/EJE-19-0390 DB - PRIME DP - Unbound Medicine ER -