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Acute effect of smoking on rebreathing carbon monoxide, breath-hold carbon monoxide and alveolar oxygen.
Clin Sci (Lond). 1988 Oct; 75(4):371-3.CS

Abstract

1. The rise ('boost') in carboxyhaemoglobin (HbCO) on smoking has been studied with alveolar carbon monoxide measurements before and after smoking a cigarette. We re-examined this in 28 subjects with HbCO values compared with rebreathing carbon monoxide [FACO(Rb)] and breath-hold alveolar carbon monoxide and oxygen concentrations, obtained after a 20 s breath-hold [FACO(Bh) and FAO2(Bh), respectively]. Tests were done in the order FACO(Bh) and FAO2(Bh), FACO(Rb), FACO(Bh) and FAO2(Bh) before and after smoking a single cigarette, with HbCO being measured 1 min before and after smoking. 2. The changes were expressed as the relative boost: (Post value-pre value)/(Pre value + post value)/2 X 100 For HbCO the average value was 23.7%, but the FACO(Rb) boost was only 9.8%. The first post-smoking FACO(Bh) boost was 3.9% (5.0 min after smoking), rising to 8.5% 9.4 min later. 3. The FAO2(Bh) values fell from a mean of 15.4% before smoking to 14.3% (5.0 min after smoking) then recovered to 15.4% 9.4 min later, suggesting a transient effect on pulmonary gas exchange. Correction of the first post-smoke FACO(Bh) data for this effect increased the relative boost to 11.5%. Routine FAO2(Bh) measurements may be useful in further smoking studies. 4. We conclude that none of the alveolar sampling techniques gives a reliable measurement of the acute HbCO changes associated with smoking.

Authors+Show Affiliations

Kirkham AJ
Midhurst Medical Research Institute, Guildford, Surrey, U.K.
Guyatt AR
No affiliation info available
Cumming G
No affiliation info available

MeSH

AdultAgedBreath TestsCarbon MonoxideCarboxyhemoglobinHumansMaleMiddle AgedOxygenPulmonary AlveoliRespirationSmokingVentilation-Perfusion Ratio

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3197371

Citation

Kirkham, A J., et al. "Acute Effect of Smoking On Rebreathing Carbon Monoxide, Breath-hold Carbon Monoxide and Alveolar Oxygen." Clinical Science (London, England : 1979), vol. 75, no. 4, 1988, pp. 371-3.
Kirkham AJ, Guyatt AR, Cumming G. Acute effect of smoking on rebreathing carbon monoxide, breath-hold carbon monoxide and alveolar oxygen. Clin Sci (Lond). 1988;75(4):371-3.
Kirkham, A. J., Guyatt, A. R., & Cumming, G. (1988). Acute effect of smoking on rebreathing carbon monoxide, breath-hold carbon monoxide and alveolar oxygen. Clinical Science (London, England : 1979), 75(4), 371-3.
Kirkham AJ, Guyatt AR, Cumming G. Acute Effect of Smoking On Rebreathing Carbon Monoxide, Breath-hold Carbon Monoxide and Alveolar Oxygen. Clin Sci (Lond). 1988;75(4):371-3. PubMed PMID: 3197371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effect of smoking on rebreathing carbon monoxide, breath-hold carbon monoxide and alveolar oxygen. AU - Kirkham,A J, AU - Guyatt,A R, AU - Cumming,G, PY - 1988/10/1/pubmed PY - 1988/10/1/medline PY - 1988/10/1/entrez SP - 371 EP - 3 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 75 IS - 4 N2 - 1. The rise ('boost') in carboxyhaemoglobin (HbCO) on smoking has been studied with alveolar carbon monoxide measurements before and after smoking a cigarette. We re-examined this in 28 subjects with HbCO values compared with rebreathing carbon monoxide [FACO(Rb)] and breath-hold alveolar carbon monoxide and oxygen concentrations, obtained after a 20 s breath-hold [FACO(Bh) and FAO2(Bh), respectively]. Tests were done in the order FACO(Bh) and FAO2(Bh), FACO(Rb), FACO(Bh) and FAO2(Bh) before and after smoking a single cigarette, with HbCO being measured 1 min before and after smoking. 2. The changes were expressed as the relative boost: (Post value-pre value)/(Pre value + post value)/2 X 100 For HbCO the average value was 23.7%, but the FACO(Rb) boost was only 9.8%. The first post-smoking FACO(Bh) boost was 3.9% (5.0 min after smoking), rising to 8.5% 9.4 min later. 3. The FAO2(Bh) values fell from a mean of 15.4% before smoking to 14.3% (5.0 min after smoking) then recovered to 15.4% 9.4 min later, suggesting a transient effect on pulmonary gas exchange. Correction of the first post-smoke FACO(Bh) data for this effect increased the relative boost to 11.5%. Routine FAO2(Bh) measurements may be useful in further smoking studies. 4. We conclude that none of the alveolar sampling techniques gives a reliable measurement of the acute HbCO changes associated with smoking. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/3197371/Acute_effect_of_smoking_on_rebreathing_carbon_monoxide_breath_hold_carbon_monoxide_and_alveolar_oxygen_ DB - PRIME DP - Unbound Medicine ER -