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Evaluation of adnexal tumours in the International Ovarian Tumor Analysis system in reference to histopathological results.
Prz Menopauzalny. 2019 Dec; 18(3):141-145.PM

Abstract

Aim of the study

To retrospectively evaluate how the International Ovarian Tumor Analysis (IOTA) simple rules used in ultrasound examinations estimate the probability of malignant and benign tumour occurrence in the studied population.

Material and methods

The study was performed on a group of 425 patients with ovarian tumours operated in the Clinic of Surgical and Oncological Gynecology at the Medical University of Lodz in the years 2014-2015. Adnexal tumours were rated according to IOTA simple rules, classifying them as probably malignant, probably benign, or unclassified. The results of the study were compared with final histopathological results. The statistical analysis was performed using STATISTICA 13 PL with Medical Pack.

Results

We analysed data on n = 43 (11%) patients with malignant, n = 346 (86%) patients with benign, and n = 12 (3%) patients with borderline tumours, respectively. Malignant tumour patients were significantly older (mean age 61.0 ±11.6 vs. 43.6 ±16.2 years, p< 0.001), had higher BMI (mean 27.3 ±7.0 vs. 25.2 ±5.2, p< 0.05), more pregnancies (median 2 vs. 1, p = 0.001), and higher cancer antigen 125 (CA 125) concentrations (median 251.5 vs. 18.5, p< 0.001) than patients with a benign tumour. Also, they more often suffered from diabetes mellitus (19% vs. 8%, p = 0.02) and arterial hypertension (60% vs. 42%, p< 0.01) than benign tumour patients.

Conclusions

In our study, IOTA performance in predicting or ruling out a malignant tumour was highly satisfactory and similar to that of CA 125. Both the methods may be complementary and used to assess the risk of malignant vs. benign ovarian neoplasm, although the context of other clinical variables may also be important.

Authors+Show Affiliations

1 Department of Gynaecology and Obstetrics, Clinic of Surgical and Oncological Gynecology, M. Pirogow's Teaching Hospital, Medical University of Lodz, Lodz, Poland.Department of Operative Gynaecology and Gynaecological Oncology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.Department of Operative Gynaecology and Gynaecological Oncology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.Department of Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.1 Department of Gynaecology and Obstetrics, Clinic of Surgical and Oncological Gynecology, M. Pirogow's Teaching Hospital, Medical University of Lodz, Lodz, Poland.1 Department of Gynaecology and Obstetrics, Clinic of Surgical and Oncological Gynecology, M. Pirogow's Teaching Hospital, Medical University of Lodz, Lodz, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31975980

Citation

Nowak, Anna, et al. "Evaluation of Adnexal Tumours in the International Ovarian Tumor Analysis System in Reference to Histopathological Results." Przeglad Menopauzalny = Menopause Review, vol. 18, no. 3, 2019, pp. 141-145.
Nowak A, Soja M, Masternak M, et al. Evaluation of adnexal tumours in the International Ovarian Tumor Analysis system in reference to histopathological results. Prz Menopauzalny. 2019;18(3):141-145.
Nowak, A., Soja, M., Masternak, M., Mokros, Ł., Wilczyński, J., & Szubert, M. (2019). Evaluation of adnexal tumours in the International Ovarian Tumor Analysis system in reference to histopathological results. Przeglad Menopauzalny = Menopause Review, 18(3), 141-145. https://doi.org/10.5114/pm.2019.90812
Nowak A, et al. Evaluation of Adnexal Tumours in the International Ovarian Tumor Analysis System in Reference to Histopathological Results. Prz Menopauzalny. 2019;18(3):141-145. PubMed PMID: 31975980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of adnexal tumours in the International Ovarian Tumor Analysis system in reference to histopathological results. AU - Nowak,Anna, AU - Soja,Malwina, AU - Masternak,Martyna, AU - Mokros,Łukasz, AU - Wilczyński,Jacek, AU - Szubert,Maria, Y1 - 2019/12/20/ PY - 2019/06/11/received PY - 2019/11/07/accepted PY - 2020/1/25/entrez PY - 2020/1/25/pubmed PY - 2020/1/25/medline KW - CA 125 KW - IOTA KW - benign KW - malignant KW - ovarian tumour KW - prediction SP - 141 EP - 145 JF - Przeglad menopauzalny = Menopause review JO - Prz Menopauzalny VL - 18 IS - 3 N2 - Aim of the study: To retrospectively evaluate how the International Ovarian Tumor Analysis (IOTA) simple rules used in ultrasound examinations estimate the probability of malignant and benign tumour occurrence in the studied population. Material and methods: The study was performed on a group of 425 patients with ovarian tumours operated in the Clinic of Surgical and Oncological Gynecology at the Medical University of Lodz in the years 2014-2015. Adnexal tumours were rated according to IOTA simple rules, classifying them as probably malignant, probably benign, or unclassified. The results of the study were compared with final histopathological results. The statistical analysis was performed using STATISTICA 13 PL with Medical Pack. Results: We analysed data on n = 43 (11%) patients with malignant, n = 346 (86%) patients with benign, and n = 12 (3%) patients with borderline tumours, respectively. Malignant tumour patients were significantly older (mean age 61.0 ±11.6 vs. 43.6 ±16.2 years, p< 0.001), had higher BMI (mean 27.3 ±7.0 vs. 25.2 ±5.2, p< 0.05), more pregnancies (median 2 vs. 1, p = 0.001), and higher cancer antigen 125 (CA 125) concentrations (median 251.5 vs. 18.5, p< 0.001) than patients with a benign tumour. Also, they more often suffered from diabetes mellitus (19% vs. 8%, p = 0.02) and arterial hypertension (60% vs. 42%, p< 0.01) than benign tumour patients. Conclusions: In our study, IOTA performance in predicting or ruling out a malignant tumour was highly satisfactory and similar to that of CA 125. Both the methods may be complementary and used to assess the risk of malignant vs. benign ovarian neoplasm, although the context of other clinical variables may also be important. SN - 1643-8876 UR - https://www.unboundmedicine.com/medline/citation/31975980/Evaluation_of_adnexal_tumours_in_the_International_Ovarian_Tumor_Analysis_system_in_reference_to_histopathological_results L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31975980/ DB - PRIME DP - Unbound Medicine ER -
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