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Early life triclosan exposure and neurodevelopment of children at 3 years in a prospective birth cohort.
Int J Hyg Environ Health. 2020 03; 224:113427.IJ

Abstract

BACKGROUND

Early life exposure to triclosan, an emerging endocrine disrupting chemical, may adversely impact childhood neurodevelopment, but limited epidemiologic studies have examined the associations.

OBJECTIVE

We evaluated the associations between prenatal and postnatal triclosan exposure and child neurodevelopment at 3 years.

METHODS

The study included 377 mother-child pairs who participated in Sheyang Mini Birth Cohort Study (SMBCS), a longitudinal birth cohort in China. Triclosan concentrations in maternal and 3-year-old child urine samples were quantified using gas chromatography-tandem mass spectrometry (GC-MS/MS). Gesell Developmental Schedules (GDS) were used to assess child neurodevelopment at 3 years of age. Multivariate linear regression models were applied to estimate associations of prenatal and postnatal urinary triclosan concentrations with children's developmental quotients (DQs).

RESULTS

Detection frequencies of triclosan in maternal and childhood urine samples were 100% and 99.5%, respectively. The median values of prenatal and postnatal urinary triclosan levels were 0.65 and 0.44 μg/L, respectively. One ln-unit increase of maternal urinary triclosan concentration was associated with increase of DQ scores in motor area of children (regression coefficient, β = 0.28, 95% confidence interval, CI: 0.03, 0.54; p = 0.03). In sex-stratified analyses, maternal urinary triclosan levels were significantly related to increases in DQ scores in motor area among boys (β = 0.25, 95%CI: 0.01, 0.50; p = 0.04), while postnatal urinary triclosan concentrations were inversely associated with DQ scores in social area in boys (β = -0.37, 95%CI: -0.72, -0.03; p = 0.03).

CONCLUSIONS

The findings suggested that prenatal triclosan exposure predicted increases in motor scores, while postnatal triclosan exposure was related to reductions in social scores of 3-year-old children. These associations were only observed in boys. The biological mechanisms linking triclosan exposure to neurodevelopment await further studies.

Authors+Show Affiliations

School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: chwu@fudan.edu.cn.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai, 200336, China.Zhejiang Provincial Center for Disease Control and Prevention, No. 3399 Binsheng Road, Hangzhou, 310051, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai, 200336, China.Changning District Center for Disease Control and Prevention, No.39 Yunwushan Road, Shanghai, 200051, China.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.Changning District Center for Disease Control and Prevention, No.39 Yunwushan Road, Shanghai, 200051, China.Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, 70182, Sweden.Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai, 200336, China.School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: zjzhou@fudan.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31978725

Citation

Guo, Jianqiu, et al. "Early Life Triclosan Exposure and Neurodevelopment of Children at 3 Years in a Prospective Birth Cohort." International Journal of Hygiene and Environmental Health, vol. 224, 2020, p. 113427.
Guo J, Wu C, Zhang J, et al. Early life triclosan exposure and neurodevelopment of children at 3 years in a prospective birth cohort. Int J Hyg Environ Health. 2020;224:113427.
Guo, J., Wu, C., Zhang, J., Xiao, H., Lv, S., Lu, D., Qi, X., Feng, C., Liang, W., Chang, X., Zhang, Y., Xu, H., Cao, Y., Wang, G., & Zhou, Z. (2020). Early life triclosan exposure and neurodevelopment of children at 3 years in a prospective birth cohort. International Journal of Hygiene and Environmental Health, 224, 113427. https://doi.org/10.1016/j.ijheh.2019.113427
Guo J, et al. Early Life Triclosan Exposure and Neurodevelopment of Children at 3 Years in a Prospective Birth Cohort. Int J Hyg Environ Health. 2020;224:113427. PubMed PMID: 31978725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early life triclosan exposure and neurodevelopment of children at 3 years in a prospective birth cohort. AU - Guo,Jianqiu, AU - Wu,Chunhua, AU - Zhang,Jiming, AU - Xiao,Hongxi, AU - Lv,Shenliang, AU - Lu,Dasheng, AU - Qi,Xiaojuan, AU - Feng,Chao, AU - Liang,Weijiu, AU - Chang,Xiuli, AU - Zhang,Yubin, AU - Xu,Hao, AU - Cao,Yang, AU - Wang,Guoquan, AU - Zhou,Zhijun, Y1 - 2019/12/09/ PY - 2019/09/06/received PY - 2019/11/29/revised PY - 2019/12/02/accepted PY - 2020/1/25/pubmed PY - 2020/1/25/medline PY - 2020/1/25/entrez KW - Biomonitoring KW - Child neurodevelopment KW - Prenatal and postnatal exposure KW - Triclosan SP - 113427 EP - 113427 JF - International journal of hygiene and environmental health JO - Int J Hyg Environ Health VL - 224 N2 - BACKGROUND: Early life exposure to triclosan, an emerging endocrine disrupting chemical, may adversely impact childhood neurodevelopment, but limited epidemiologic studies have examined the associations. OBJECTIVE: We evaluated the associations between prenatal and postnatal triclosan exposure and child neurodevelopment at 3 years. METHODS: The study included 377 mother-child pairs who participated in Sheyang Mini Birth Cohort Study (SMBCS), a longitudinal birth cohort in China. Triclosan concentrations in maternal and 3-year-old child urine samples were quantified using gas chromatography-tandem mass spectrometry (GC-MS/MS). Gesell Developmental Schedules (GDS) were used to assess child neurodevelopment at 3 years of age. Multivariate linear regression models were applied to estimate associations of prenatal and postnatal urinary triclosan concentrations with children's developmental quotients (DQs). RESULTS: Detection frequencies of triclosan in maternal and childhood urine samples were 100% and 99.5%, respectively. The median values of prenatal and postnatal urinary triclosan levels were 0.65 and 0.44 μg/L, respectively. One ln-unit increase of maternal urinary triclosan concentration was associated with increase of DQ scores in motor area of children (regression coefficient, β = 0.28, 95% confidence interval, CI: 0.03, 0.54; p = 0.03). In sex-stratified analyses, maternal urinary triclosan levels were significantly related to increases in DQ scores in motor area among boys (β = 0.25, 95%CI: 0.01, 0.50; p = 0.04), while postnatal urinary triclosan concentrations were inversely associated with DQ scores in social area in boys (β = -0.37, 95%CI: -0.72, -0.03; p = 0.03). CONCLUSIONS: The findings suggested that prenatal triclosan exposure predicted increases in motor scores, while postnatal triclosan exposure was related to reductions in social scores of 3-year-old children. These associations were only observed in boys. The biological mechanisms linking triclosan exposure to neurodevelopment await further studies. SN - 1618-131X UR - https://www.unboundmedicine.com/medline/citation/31978725/Early_life_triclosan_exposure_and_neurodevelopment_of_children_at_3_years_in_a_prospective_birth_cohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1438-4639(19)30788-6 DB - PRIME DP - Unbound Medicine ER -
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