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Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272.
Mar Drugs. 2020 Jan 23; 18(2)MD

Abstract

Three new polyketides, ketidocillinones A-C (1-3), were discovered from the extract of an Antarctica sponge-derived fungus Penicillium sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound 3 was established by using ECD calculation. Compounds 1-3 can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C (2 and 3) exhibited potent antibacterial activity against Pseudomonas aeurigenosa, Mycobacterium phlei, and MRCNS (methicillin-resistant coagulase-negative staphylococci) with MIC values ranging from 1.56 to 25.00 µg/mL.

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Authors+Show Affiliations

Shah M
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Sun C
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Sun Z
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Zhang G
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China.
Che Q
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Gu Q
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Zhu T
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Li D
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China. Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China.

MeSH

AnimalsAntarctic RegionsAnti-Bacterial AgentsAquatic OrganismsMagnetic Resonance SpectroscopyMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular StructureMycobacterium phleiPenicilliumPolyketidesPoriferaPseudomonas aeruginosa

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31979231

Citation

Shah, Mudassir, et al. "Antibacterial Polyketides From Antarctica Sponge-Derived Fungus Penicillium Sp. HDN151272." Marine Drugs, vol. 18, no. 2, 2020.
Shah M, Sun C, Sun Z, et al. Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272. Mar Drugs. 2020;18(2).
Shah, M., Sun, C., Sun, Z., Zhang, G., Che, Q., Gu, Q., Zhu, T., & Li, D. (2020). Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272. Marine Drugs, 18(2). https://doi.org/10.3390/md18020071
Shah M, et al. Antibacterial Polyketides From Antarctica Sponge-Derived Fungus Penicillium Sp. HDN151272. Mar Drugs. 2020 Jan 23;18(2) PubMed PMID: 31979231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272. AU - Shah,Mudassir, AU - Sun,Chunxiao, AU - Sun,Zichao, AU - Zhang,Guojian, AU - Che,Qian, AU - Gu,Qianqun, AU - Zhu,Tianjiao, AU - Li,Dehai, Y1 - 2020/01/23/ PY - 2019/12/12/received PY - 2020/01/17/revised PY - 2020/01/20/accepted PY - 2020/1/26/entrez PY - 2020/1/26/pubmed PY - 2020/10/21/medline KW - Antarctica sponge-derived fungus KW - Penicillium sp. KW - antibacterial activity KW - polyketides JF - Marine drugs JO - Mar Drugs VL - 18 IS - 2 N2 - Three new polyketides, ketidocillinones A-C (1-3), were discovered from the extract of an Antarctica sponge-derived fungus Penicillium sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound 3 was established by using ECD calculation. Compounds 1-3 can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C (2 and 3) exhibited potent antibacterial activity against Pseudomonas aeurigenosa, Mycobacterium phlei, and MRCNS (methicillin-resistant coagulase-negative staphylococci) with MIC values ranging from 1.56 to 25.00 µg/mL. SN - 1660-3397 UR - https://www.unboundmedicine.com/medline/citation/31979231/Antibacterial_Polyketides_from_Antarctica_Sponge_Derived_Fungus_Penicillium_sp__HDN151272_ DB - PRIME DP - Unbound Medicine ER -