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Lung Cancer Screening by Low-Dose CT Scan: Baseline Results of a French Prospective Study.

Abstract

BACKGROUND

Lung cancer mortality has been found to decrease significantly with low-dose (LD) computed tomographic (CT) screening among current or former smokers. However, such a screening program is not implemented in France. This study assessed the feasibility of a lung cancer screening program using LD CT scan in a French administrative territory. We report here the results of the first screening round.

PATIENTS AND METHODS

DEP KP80 was a single-arm prospective study initiated in May 2016. Participants aged 55 to 74 years, current or former smokers of ≥ 30 pack-years, were recruited. An annual LD CT scan was scheduled. Our algorithms considered nodules < 5 mm as negative findings and nodules > 10 mm as positive; for intermediate nodules between 5 and 10 mm, 3-month CT scan with doubling time measurement was recommended. All general practitioners, pulmonologists, and radiologists from the Somme department were solicited to participate. Subjects were selected by general practitioners or pulmonologists who checked the inclusion criteria and prescribed the CT scan.

RESULTS

Over a 2.5-year period, 1307 subjects were recruited. Screening was negative in 733 cases (77.2%), positive in 54 (5.7%), and indeterminate in 162 (17.1%). After the 3-month scans, 57 subjects screened positive: 26 patients exhibited 31 lung cancers (67.7% of stage 0 to I), of whom 76.9% underwent surgical resection, and 29 had no cancer (false-positive rate = 3.1%). The prevalence of lung cancer was 2.7%.

CONCLUSION

This study demonstrated the feasibility of organized lung cancer screening using LD CT scan within a real-life context in the general population.

Authors+Show Affiliations

Department of Pulmonology, Center Hospitalier d'Abbeville, Abbeville, France. Electronic address: leleu.olivier@ch-abbeville.fr.Department of Pulmonology, CHU Amiens, Amiens, France.Department of Radiology, CHU Amiens, Amiens, France.Department of Pulmonology, Center Hospitalier d'Abbeville, Abbeville, France.Department of Pulmonology, Center Hospitalier d'Abbeville, Abbeville, France.ADEMA80, Amiens, France.Department of Pulmonology, CHU Amiens, Amiens, France.Intergroupe francophone de cancérologie thoracique (IFCT), Paris, France.Department of Medical Oncology, CHU Amiens, Amiens, France.Department of Thoracic Surgery, CHU Amiens, Amiens, France.Department of Pulmonology, CHU Amiens, Amiens, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31982356

Citation

Leleu, Olivier, et al. "Lung Cancer Screening By Low-Dose CT Scan: Baseline Results of a French Prospective Study." Clinical Lung Cancer, 2019.
Leleu O, Basille D, Auquier M, et al. Lung Cancer Screening by Low-Dose CT Scan: Baseline Results of a French Prospective Study. Clin Lung Cancer. 2019.
Leleu, O., Basille, D., Auquier, M., Clarot, C., Hoguet, E., Pétigny, V., ... Jounieaux, V. (2019). Lung Cancer Screening by Low-Dose CT Scan: Baseline Results of a French Prospective Study. Clinical Lung Cancer, doi:10.1016/j.cllc.2019.10.014.
Leleu O, et al. Lung Cancer Screening By Low-Dose CT Scan: Baseline Results of a French Prospective Study. Clin Lung Cancer. 2019 Oct 31; PubMed PMID: 31982356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lung Cancer Screening by Low-Dose CT Scan: Baseline Results of a French Prospective Study. AU - Leleu,Olivier, AU - Basille,Damien, AU - Auquier,Marianne, AU - Clarot,Caroline, AU - Hoguet,Estelle, AU - Pétigny,Valérie, AU - Addi,Amale Aït, AU - Milleron,Bernard, AU - Chauffert,Bruno, AU - Berna,Pascal, AU - Jounieaux,Vincent, Y1 - 2019/10/31/ PY - 2019/04/26/received PY - 2019/09/06/revised PY - 2019/10/18/accepted PY - 2020/1/27/entrez PY - 2020/1/27/pubmed PY - 2020/1/27/medline KW - Low dose CT scan KW - Lung cancer KW - Lung nodule KW - Screening KW - Tobacco smoking JF - Clinical lung cancer JO - Clin Lung Cancer N2 - BACKGROUND: Lung cancer mortality has been found to decrease significantly with low-dose (LD) computed tomographic (CT) screening among current or former smokers. However, such a screening program is not implemented in France. This study assessed the feasibility of a lung cancer screening program using LD CT scan in a French administrative territory. We report here the results of the first screening round. PATIENTS AND METHODS: DEP KP80 was a single-arm prospective study initiated in May 2016. Participants aged 55 to 74 years, current or former smokers of ≥ 30 pack-years, were recruited. An annual LD CT scan was scheduled. Our algorithms considered nodules < 5 mm as negative findings and nodules > 10 mm as positive; for intermediate nodules between 5 and 10 mm, 3-month CT scan with doubling time measurement was recommended. All general practitioners, pulmonologists, and radiologists from the Somme department were solicited to participate. Subjects were selected by general practitioners or pulmonologists who checked the inclusion criteria and prescribed the CT scan. RESULTS: Over a 2.5-year period, 1307 subjects were recruited. Screening was negative in 733 cases (77.2%), positive in 54 (5.7%), and indeterminate in 162 (17.1%). After the 3-month scans, 57 subjects screened positive: 26 patients exhibited 31 lung cancers (67.7% of stage 0 to I), of whom 76.9% underwent surgical resection, and 29 had no cancer (false-positive rate = 3.1%). The prevalence of lung cancer was 2.7%. CONCLUSION: This study demonstrated the feasibility of organized lung cancer screening using LD CT scan within a real-life context in the general population. SN - 1938-0690 UR - https://www.unboundmedicine.com/medline/citation/31982356/Lung_Cancer_Screening_by_Low-Dose_CT_Scan:_Baseline_Results_of_a_French_Prospective_Study L2 - https://linkinghub.elsevier.com/retrieve/pii/S1525-7304(19)30288-8 DB - PRIME DP - Unbound Medicine ER -