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Bactericidal and clinical efficacy of photochemotherapy in acute necrotizing ulcerative gingivitis.
Photodiagnosis Photodyn Ther. 2020 Mar; 29:101668.PP

Abstract

AIM

This study was designed to investigate the clinical and microbiological parameters with photochemotherapy (PCT) against conventional debridement (CD) among patients with necrotizing ulcerative gingivitis (NUG).

MATERIALS AND METHODS

Patients with a diagnosis of NUG were divided into two groups: 'Group-PCT' that underwent indocyanine green-mediated PCT with adjunctive mechanical debridement, and Group-CD that underwent mechanical debridement with adjunctive 3 % hydrogen peroxide/chlorhexidine rinse. Clinical inflammatory gingival parameters including full-mouth plaque scores (FMPS), bleeding scores (FMBS), and probing depth (PD) were measured. Counts of Treponema microdentium, Fusobacterium nucleatum and Prevotella intermedia were assessed using polymerase chain reaction technique. All assessments were done at baseline, 3 weeks and 6 weeks.

RESULTS

Twenty-six participants were contacted and agreed to participate in the trial. The mean age of participants in group-PCT was 24.5 years while the mean age of patients in group-CD was 26.7 years. FMPS showed significant but equal reduction in both the groups at 3 weeks and 6 weeks (p < 0.01). The reduction in mean FMBS was higher in the group-PCT at 6 weeks follow-up (p < 0.05). All bacterial levels reduced from baseline to follow-up with both PCT and CD groups (p < 0.05). Group-PCT showed significantly reduced counts of T. microdentium and F. nucleatum at 3 weeks and 6 weeks compared with group-CD (p = 0.024). Equal reduction was shown for P. intermedia between both the groups at 3 and 6 weeks, respectively.

CONCLUSION

Application of adjunctive photochemotherapy was both clinically and microbiologically effective in the treatment of NUG.

Authors+Show Affiliations

Dental Materials Department, Baqai Dental College, Baqai Medical University, Karachi, Pakistan. Electronic address: adelziasidd@gmail.com.Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.Applied Medical Science Department, CC, King Saud University, Riyadh 11433, Saudi Arabia; Biomedical Engineering Department, Faculty of Engineering, Helwan University, Helwan, Egypt.Mujahid Dental Clinic, Karachi, Pakistan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31988023

Citation

Siddiqui, Adel Zia, et al. "Bactericidal and Clinical Efficacy of Photochemotherapy in Acute Necrotizing Ulcerative Gingivitis." Photodiagnosis and Photodynamic Therapy, vol. 29, 2020, p. 101668.
Siddiqui AZ, Vellappally S, Fouad H, et al. Bactericidal and clinical efficacy of photochemotherapy in acute necrotizing ulcerative gingivitis. Photodiagnosis Photodyn Ther. 2020;29:101668.
Siddiqui, A. Z., Vellappally, S., Fouad, H., & Muckarrum, S. M. (2020). Bactericidal and clinical efficacy of photochemotherapy in acute necrotizing ulcerative gingivitis. Photodiagnosis and Photodynamic Therapy, 29, 101668. https://doi.org/10.1016/j.pdpdt.2020.101668
Siddiqui AZ, et al. Bactericidal and Clinical Efficacy of Photochemotherapy in Acute Necrotizing Ulcerative Gingivitis. Photodiagnosis Photodyn Ther. 2020;29:101668. PubMed PMID: 31988023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bactericidal and clinical efficacy of photochemotherapy in acute necrotizing ulcerative gingivitis. AU - Siddiqui,Adel Zia, AU - Vellappally,Sajith, AU - Fouad,H, AU - Muckarrum,Sheikh Muhammad, Y1 - 2020/01/24/ PY - 2020/01/04/received PY - 2020/01/13/revised PY - 2020/01/21/accepted PY - 2020/1/29/pubmed PY - 2020/1/29/medline PY - 2020/1/29/entrez KW - Antimicrobial photodynamic therapy KW - Bleeding index KW - Necrotizing ulcerative gingivitis KW - Photochemotherapy KW - Smoking SP - 101668 EP - 101668 JF - Photodiagnosis and photodynamic therapy JO - Photodiagnosis Photodyn Ther VL - 29 N2 - AIM: This study was designed to investigate the clinical and microbiological parameters with photochemotherapy (PCT) against conventional debridement (CD) among patients with necrotizing ulcerative gingivitis (NUG). MATERIALS AND METHODS: Patients with a diagnosis of NUG were divided into two groups: 'Group-PCT' that underwent indocyanine green-mediated PCT with adjunctive mechanical debridement, and Group-CD that underwent mechanical debridement with adjunctive 3 % hydrogen peroxide/chlorhexidine rinse. Clinical inflammatory gingival parameters including full-mouth plaque scores (FMPS), bleeding scores (FMBS), and probing depth (PD) were measured. Counts of Treponema microdentium, Fusobacterium nucleatum and Prevotella intermedia were assessed using polymerase chain reaction technique. All assessments were done at baseline, 3 weeks and 6 weeks. RESULTS: Twenty-six participants were contacted and agreed to participate in the trial. The mean age of participants in group-PCT was 24.5 years while the mean age of patients in group-CD was 26.7 years. FMPS showed significant but equal reduction in both the groups at 3 weeks and 6 weeks (p < 0.01). The reduction in mean FMBS was higher in the group-PCT at 6 weeks follow-up (p < 0.05). All bacterial levels reduced from baseline to follow-up with both PCT and CD groups (p < 0.05). Group-PCT showed significantly reduced counts of T. microdentium and F. nucleatum at 3 weeks and 6 weeks compared with group-CD (p = 0.024). Equal reduction was shown for P. intermedia between both the groups at 3 and 6 weeks, respectively. CONCLUSION: Application of adjunctive photochemotherapy was both clinically and microbiologically effective in the treatment of NUG. SN - 1873-1597 UR - https://www.unboundmedicine.com/medline/citation/31988023/Bactericidal_and_clinical_efficacy_of_photochemotherapy_in_acute_necrotizing_ulcerative_gingivitis L2 - https://linkinghub.elsevier.com/retrieve/pii/S1572-1000(20)30021-1 DB - PRIME DP - Unbound Medicine ER -
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